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Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Here we integrated information from predicted and experimentally verified miRNA targets to characterize protein complex networks regulated by human miRNAs. We found striking evidence that individual miRNAs or co-expressed miRNAs frequently target several components of protein complexes. We experimentally verified that the <jats:italic>miR-141-200c<\/jats:italic> cluster targets different components of the <jats:italic>CtBP\/ZEB<\/jats:italic> complex, suggesting a potential orchestrated regulation in epithelial to mesenchymal transition.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our findings indicate a coordinate posttranscriptional regulation of protein complexes by miRNAs. These provide a sound basis for designing experiments to study miRNA function at a systems level.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-5-136","type":"journal-article","created":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T18:22:51Z","timestamp":1314296571000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["MicroRNAs coordinately regulate protein complexes"],"prefix":"10.1186","volume":"5","author":[{"given":"Steffen","family":"Sass","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Dietmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike C","family":"Burk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Brabletz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Lutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kowarsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus F","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brabletz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ruepp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian J","family":"Theis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,25]]},"reference":[{"key":"735_CR1","doi-asserted-by":"publisher","first-page":"D154","DOI":"10.1093\/nar\/gkm952","volume":"36","author":"S Griffiths-Jones","year":"2008","unstructured":"Griffiths-Jones S, Saini HK, Van Dongen S, Enright AJ: \"miRBase: tools for microRNA genomics, \". 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