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If we could harness predicted interactions, such as those from a Protein-Protein Association Networks (PPAN), combining several protein-protein network function-inference methods with semantic similarity calculations, the use of protein-protein interactions for functional inference in this species would become more potentially useful.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this work we show that using PPAN data combined with other approximations, such as functional module detection, orthology exploitation methods and Gene Ontology (GO)-based information measures helps to predict protein function in <jats:italic>Mycoplasma genitalium<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>To our knowledge, the proposed method is the first that combines functional module detection among species, exploiting an orthology procedure and using information theory-based GO semantic similarity in PPAN of the <jats:italic>Mycoplasma<\/jats:italic> species. The results of an evaluation show a higher recall than previously reported methods that focused on only one organism network.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-5-49","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T06:20:52Z","timestamp":1302675652000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gene Ontology Function prediction in Mollicutes using Protein-Protein Association Networks"],"prefix":"10.1186","volume":"5","author":[{"given":"Antonio","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Cedano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Amela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Planas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Pi\u00f1ol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Querol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,4,12]]},"reference":[{"key":"640_CR1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/76443","volume":"18","author":"MY Galperin","year":"2000","unstructured":"Galperin MY, Koonin EV: Who's your neighbor? 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