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There is a strong demand to reconstruct a genome-scale metabolic network of <jats:italic>B. cenocepacia<\/jats:italic> J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We reconstructed the genome-scale metabolic network of <jats:italic>B. cenocepacia<\/jats:italic> J2315. An iterative reconstruction process led to the establishment of a robust model, <jats:italic>i<\/jats:italic> KF1028, which accounts for 1,028 genes, 859 internal reactions, and 834 metabolites. The model <jats:italic>i<\/jats:italic> KF1028 captures important metabolic capabilities of <jats:italic>B. cenocepacia<\/jats:italic> J2315 with a particular focus on the biosyntheses of key metabolic virulence factors to assist in understanding the mechanism of disease infection and identifying potential drug targets. The model was tested through BIOLOG assays. Based on the model, the genome annotation of <jats:italic>B. cenocepacia<\/jats:italic> J2315 was refined and 24 genes were properly re-annotated. Gene and enzyme essentiality were analyzed to provide further insights into the genome function and architecture. A total of 45 essential enzymes were identified as potential therapeutic targets.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>As the first genome-scale metabolic network of <jats:italic>B. cenocepacia<\/jats:italic> J2315, <jats:italic>i<\/jats:italic> KF1028 allows a systematic study of the metabolic properties of <jats:italic>B. cenocepacia<\/jats:italic> and its key metabolic virulence factors affecting the CF community. The model can be used as a discovery tool to design novel drugs against diseases caused by this notorious pathogen.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-5-83","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T06:57:57Z","timestamp":1306306677000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction"],"prefix":"10.1186","volume":"5","author":[{"given":"Kechi","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn MC","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhua","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurudutta","family":"Panda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Godinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edtor AP","family":"Martins dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,5,25]]},"reference":[{"key":"690_CR1","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1111\/j.1365-2672.2007.03706.x","volume":"104","author":"E Mahenthiralingam","year":"2008","unstructured":"Mahenthiralingam E, Baldwin A, Dowson CG: Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology. 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