{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:47Z","timestamp":1761101987092},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"S2","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>To understand how stroke risk factors mechanistically contribute to stroke, the genetic components regulating each risk factor need to be integrated and evaluated with respect to biological function and through pathway-based algorithms. This resource will provide information to researchers studying the molecular and genetic causes of stroke in terms of genomic variants, genes, and pathways.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Reported genetic variants, gene structure, phenotypes, and literature information regarding stroke were collected and extracted from publicly available databases describing variants, genome, proteome, functional annotation, and disease subtypes. Stroke related candidate pathways and etiologic genes that participate significantly in risk were analyzed in terms of canonical pathways in public biological pathway databases. These efforts resulted in a relational database of genetic signals of cerebral stroke, SigCS base, which implements an effective web retrieval system.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The current version of SigCS base documents 1943 non-redundant genes with 11472 genetic variants and 165 non-redundant pathways. The web retrieval system of SigCS base consists of two principal search flows, including: 1) a gene-based variant search using gene table browsing or a keyword search, and, 2) a pathway-based variant search using pathway table browsing. SigCS base is freely accessible at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/sysbio.kribb.re.kr\/sigcs\" ext-link-type=\"uri\">http:\/\/sysbio.kribb.re.kr\/sigcs<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>SigCS base is an effective tool that can assist researchers in the identification of the genetic factors associated with stroke by utilizing existing literature information, selecting candidate genes and variants for experimental studies, and examining the pathways that contribute to the pathophysiological mechanisms of stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-5-s2-s10","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T19:42:23Z","timestamp":1323891743000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SigCS base: an integrated genetic information resource for human cerebral stroke"],"prefix":"10.1186","volume":"5","author":[{"given":"Young-Kyu","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok Sun","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Ho","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeheup","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doheon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"800_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1159\/000210432","volume":"27","author":"P Amarenco","year":"2009","unstructured":"Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG: Classification of stroke subtypes. Cerebrovasc Dis. 2009, 27: 493-501. 10.1159\/000210432.","journal-title":"Cerebrovasc Dis"},{"key":"800_CR2","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.ncl.2008.09.001","volume":"26","author":"T Rundek","year":"2008","unstructured":"Rundek T, Sacco RL: Risk factor management to prevent first stroke. Neurol Clin. 2008, 26: 1007-1045. 10.1016\/j.ncl.2008.09.001. ix","journal-title":"Neurol Clin"},{"key":"800_CR3","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/S0895-7061(00)01249-8","volume":"13","author":"S Rubattu","year":"2000","unstructured":"Rubattu S, Giliberti R, Volpe M: Etiology and pathophysiology of stroke as a complex trait. Am J Hypertens. 2000, 13: 1139-1148. 10.1016\/S0895-7061(00)01249-8.","journal-title":"Am J Hypertens"},{"key":"800_CR4","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1161\/STROKEAHA.107.490896","volume":"38","author":"H Ay","year":"2007","unstructured":"Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG: A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007, 38: 2979-2984. 10.1161\/STROKEAHA.107.490896.","journal-title":"Stroke"},{"key":"800_CR5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","volume":"376","author":"MJ O'Donnell","year":"2010","unstructured":"O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A, Weimar C, Wang X, Yusuf S, INTERSTROKE investigators: Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010, 376: 112-123. 10.1016\/S0140-6736(10)60834-3.","journal-title":"Lancet"},{"key":"800_CR6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1474-4422(07)70007-8","volume":"6","author":"VL Feigin","year":"2007","unstructured":"Feigin VL: Stroke in developing countries: can the epidemic be stopped and outcomes improved?. Lancet Neurol. 2007, 6: 94-97. 10.1016\/S1474-4422(07)70007-8.","journal-title":"Lancet Neurol"},{"key":"800_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11883-009-0027-5","volume":"11","author":"M Fornage","year":"2009","unstructured":"Fornage M: Genetics of stroke. Curr Atheroscler Rep. 2009, 11: 167-174. 10.1007\/s11883-009-0027-5.","journal-title":"Curr Atheroscler Rep"},{"key":"800_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1365-2796.2009.02202.x","volume":"267","author":"M Matarin","year":"2010","unstructured":"Matarin M, Singleton A, Hardy J, Meschia J: The genetics of ischaemic stroke. J Intern Med. 2010, 267: 139-155. 10.1111\/j.1365-2796.2009.02202.x.","journal-title":"J Intern Med"},{"key":"800_CR9","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1161\/STROKEAHA.109.570523","volume":"41","author":"MB Lanktree","year":"2010","unstructured":"Lanktree MB, Dichgans M, Hegele RA: Advances in genomic analysis of stroke: what have we learned and where are we headed?. Stroke. 2010, 41: 825-832. 10.1161\/STROKEAHA.109.570523.","journal-title":"Stroke"},{"key":"800_CR10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/S1474-4422(07)70081-9","volume":"6","author":"M Matar\u00edn","year":"2007","unstructured":"Matar\u00edn M, Brown WM, Scholz S, Sim\u00f3n-S\u00e1nchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, Silliman S, Case LD, Singleton A, Hardy JA, Rich SS, Meschia JF: A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol. 2007, 6: 414-420. 10.1016\/S1474-4422(07)70081-9.","journal-title":"Lancet Neurol"},{"key":"800_CR11","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/ng.240","volume":"40","author":"K Bilguvar","year":"2008","unstructured":"Bilguvar K, Yasuno K, Niemel\u00e4 M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, van den Berg LH, Mane S, Mason CE, Choi M, Ga\u00e1l E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MM, Wijmenga C, State MW, Rinkel GJ, Hernesniemi J, J\u00e4\u00e4skel\u00e4inen JE, Palotie A, Inoue I, Lifton RP, G\u00fcnel M: Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet. 2008, 40: 1472-1477. 10.1038\/ng.240.","journal-title":"Nat Genet"},{"key":"800_CR12","doi-asserted-by":"publisher","first-page":"e3691","DOI":"10.1371\/journal.pone.0003691","volume":"3","author":"G Peck","year":"2008","unstructured":"Peck G, Smeeth L, Whittaker J, Casas JP, Hingorani A, Sharma P: The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS One. 2008, 3: e3691-10.1371\/journal.pone.0003691.","journal-title":"PLoS One"},{"key":"800_CR13","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nature05616","volume":"445","author":"R Sladek","year":"2007","unstructured":"Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007, 445: 881-885. 10.1038\/nature05616.","journal-title":"Nature"},{"key":"800_CR14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.5808\/GI.2008.6.3.153","volume":"6","author":"YU Kim","year":"2008","unstructured":"Kim YU, Kim IH, Bang OS, Kim YJ: StrokeBase: a database of cerebrovascular disease-related candidate genes. Genomics Informatics. 2008, 6: 153-156. 10.5808\/GI.2008.6.3.153.","journal-title":"Genomics Informatics"},{"key":"800_CR15","doi-asserted-by":"publisher","first-page":"D793","DOI":"10.1093\/nar\/gkn665","volume":"37","author":"J Amberger","year":"2009","unstructured":"Amberger J, Bocchini CA, Scott AF, Hamosh A: McKusick's Online Mendelian Inheritance in Man (OMIM). Nucleic Acids Res. 2009, 37: D793-D796. 10.1093\/nar\/gkn665.","journal-title":"Nucleic Acids Res"},{"key":"800_CR16","doi-asserted-by":"publisher","first-page":"D142","DOI":"10.1093\/nar\/gkp846","volume":"38","author":"UniProt consortium","year":"2010","unstructured":"UniProt consortium: The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 2010, 38: D142-D148.","journal-title":"Nucleic Acids Res"},{"key":"800_CR17","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/nar\/29.1.308","volume":"29","author":"ST Sherry","year":"2001","unstructured":"Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 2001, 29: 308-311. 10.1093\/nar\/29.1.308.","journal-title":"Nucleic Acids Res"},{"key":"800_CR18","doi-asserted-by":"publisher","first-page":"D613","DOI":"10.1093\/nar\/gkp939","volume":"38","author":"B Rhead","year":"2010","unstructured":"Rhead B, Karolchik D, Kuhn RM, Hinrichs AS, Zweig AS, Fujita PA, Diekhans M, Smith KE, Rosenbloom KR, Raney BJ, Pohl A, Pheasant M, Meyer LR, Learned K, Hsu F, Hillman-Jackson J, Harte RA, Giardine B, Dreszer TR, Clawson H, Barber GP, Haussler D, Kent WJ: The UCSC Genome Browser database: update 2010. Nucleic Acids Res. 2010, 38: D613-619.","journal-title":"Nucleic Acids Res"},{"key":"800_CR19","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s00439-001-0615-0","volume":"109","author":"S Povey","year":"2001","unstructured":"Povey S, Lovering R, Bruford E, Wright M, Lush M, Wain H: The HUGO Gene Nomenclature Committee (HGNC). Hum Genet. 2001, 109: 678-680. 10.1007\/s00439-001-0615-0.","journal-title":"Hum Genet"},{"key":"800_CR20","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005, 102: 15545-15550. 10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"800_CR21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.atherosclerosis.2008.10.028","volume":"205","author":"F Veglio","year":"2009","unstructured":"Veglio F, Paglieri C, Rabbia F, Bisbocci D, Bergui M, Cerrato P: Hypertension and cerebrovascular damage. Atherosclerosis. 2009, 205: 331-341. 10.1016\/j.atherosclerosis.2008.10.028.","journal-title":"Atherosclerosis"},{"key":"800_CR22","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11883-010-0117-4","volume":"12","author":"A Lewis","year":"2010","unstructured":"Lewis A, Segal A: Hyperlipidemia and primary prevention of stroke: does risk factor identification and reduction really work?. Curr Atheroscler Rep. 2010, 12: 225-229. 10.1007\/s11883-010-0117-4.","journal-title":"Curr Atheroscler Rep"},{"key":"800_CR23","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1161\/STROKEAHA.109.577510","volume":"41","author":"A Towfighi","year":"2010","unstructured":"Towfighi A, Zheng L, Ovbiagele B: Weight of the obesity epidemic: rising stroke rates among middle-aged women in the United States. Stroke. 2010, 41: 1371-1375. 10.1161\/STROKEAHA.109.577510.","journal-title":"Stroke"},{"key":"800_CR24","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1159\/000149577","volume":"26","author":"C Li","year":"2008","unstructured":"Li C, Engstrom G, Berglund G, Janzon L, Hedblad B: Incidence of ischemic stroke in relation to asymptomatic carotid artery atherosclerosis in subjects with normal blood pressure. A prospective cohort study. Cerebrovasc Dis. 2008, 26: 297-303. 10.1159\/000149577.","journal-title":"Cerebrovasc Dis"},{"key":"800_CR25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3109\/10408361003791520","volume":"47","author":"S Stankovic","year":"2010","unstructured":"Stankovic S, Majkic-Singh N: Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factors. Crit Rev Clin Lab Sci. 2010, 47: 72-123. 10.3109\/10408361003791520.","journal-title":"Crit Rev Clin Lab Sci"},{"key":"800_CR26","first-page":"10","volume":"72","author":"G Sirico","year":"2009","unstructured":"Sirico G, Spadera L, De Laurentis M, Brevetti G: Carotid artery disease and stroke in patients with peripheral arterial disease. The role of inflammation. Monaldi Arch Chest Dis. 2009, 72: 10-17.","journal-title":"Monaldi Arch Chest Dis"},{"key":"800_CR27","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/ATVBAHA.107.151787","volume":"28","author":"S Kinlay","year":"2008","unstructured":"Kinlay S, Schwartz GG, Olsson AG, Rifai N, Szarek M, Waters DD, Libby P, Ganz P: Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study. Arterioscler Thromb Vasc Biol. 2008, 28: 142-147.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"800_CR28","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/JNN.0b013e31819345f8","volume":"41","author":"E Carwile","year":"2009","unstructured":"Carwile E, Wagner AK, Crago E, Alexander SA: Estrogen and stroke: a review of the current literature. J Neurosci Nurs. 2009, 41: 18-25. 10.1097\/JNN.0b013e31819345f8.","journal-title":"J Neurosci Nurs"},{"key":"800_CR29","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1212\/01.wnl.0000250238.69938.f5","volume":"68","author":"MA de Lecin\u00e3na","year":"2007","unstructured":"de Lecin\u00e3na MA, Egido JA, Fern\u00e1ndez C, Mart\u00ednez-Vila E, Santos S, Morales A, Mart\u00ednez E, Pareja A, Alvarez-Sab\u00edn J, Casado I, PIVE Study Investigators of the Stroke Project of the Spanish Cerebrovascular Diseases Study Group: Risk of ischemic stroke and lifetime estrogen exposure. Neurology. 2007, 68: 33-38. 10.1212\/01.wnl.0000250238.69938.f5.","journal-title":"Neurology"},{"key":"800_CR30","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1620\/tjem.218.293","volume":"218","author":"N Tascilar","year":"2009","unstructured":"Tascilar N, Ekem S, Aciman E, Ankarali H, Mungan G, Ozen B, Unal A: Hyperhomocysteinemia as an independent risk factor for cardioembolic stroke in the Turkish population. Tohoku J Exp Med. 2009, 218: 293-300. 10.1620\/tjem.218.293.","journal-title":"Tohoku J Exp Med"},{"key":"800_CR31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1468-1331.2004.00954.x","volume":"12","author":"R Herzig","year":"2005","unstructured":"Herzig R, Bogousslavsky J, Maeder P, Maeder-Ingvar M, Reichhart M, Urbano LA, Leemann B: Intracranial arterial and arteriovenous malformations presenting with infarction. Lausanne Stroke Registry study. Eur J Neurol. 2005, 12: 93-102. 10.1111\/j.1468-1331.2004.00954.x.","journal-title":"Eur J Neurol"},{"key":"800_CR32","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3171\/jns.1998.89.4.0539","volume":"89","author":"G Redekop","year":"1998","unstructured":"Redekop G, TerBrugge K, Montanera W, Willinsky R: Arterial aneurysms associated with cerebral arteriovenous malformations: classification, incidence, and risk of hemorrhage. J Neurosurg. 1998, 89: 539-546. 10.3171\/jns.1998.89.4.0539.","journal-title":"J Neurosurg"},{"key":"800_CR33","doi-asserted-by":"publisher","first-page":"D26","DOI":"10.1093\/nar\/gkl993","volume":"35","author":"D Maglott","year":"2007","unstructured":"Maglott D, Ostell J, Pruitt KD, Tatusova T: Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2007, 35: D26-31. 10.1093\/nar\/gkl993.","journal-title":"Nucleic Acids Res"},{"key":"800_CR34","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/1471-2164-11-295","volume":"11","author":"GM Spudich","year":"2010","unstructured":"Spudich GM, Fernandez-Suarez XM: Touring Ensembl: a practical guide to genome browsing. BMC Genomics. 2010, 11: 295-10.1186\/1471-2164-11-295.","journal-title":"BMC Genomics"},{"key":"800_CR35","doi-asserted-by":"publisher","first-page":"D767","DOI":"10.1093\/nar\/gkn892","volume":"37","author":"TS Keshava Prasad","year":"2009","unstructured":"Keshava Prasad TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, Mathivanan S, Telikicherla D, Raju R, Shafreen B, Venugopal A, Balakrishnan L, Marimuthu A, Banerjee S, Somanathan DS, Sebastian A, Rani S, Ray S, Harrys Kishore CJ, Kanth S, Ahmed M, Kashyap MK, Mohmood R, Ramachandra YL, Krishna V, Rahiman BA, Mohan S, Ranganathan P, Ramabadran S, Chaerkady R, Pandey A: Human Protein Reference Database--2009 update. Nucleic Acids Res. 2009, 37: D767-772. 10.1093\/nar\/gkn892.","journal-title":"Nucleic Acids Res"},{"key":"800_CR36","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1117196","volume":"310","author":"S Myers","year":"2005","unstructured":"Myers S, Bottolo L, Freeman C, McVean G, Donnelly P: A fine-scale map of recombination rates and hotspots across the human genome. Science. 2005, 310: 321-324. 10.1126\/science.1117196.","journal-title":"Science"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-5-S2-S10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T17:47:06Z","timestamp":1630518426000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-5-S2-S10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":36,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["800"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-5-s2-s10","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"14 December 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"S10"}}