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To our knowledge there has not been a genetic approach to elucidate the regulatory role of the different enzymes of the glycolytic pathway.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We report that the laboratory strain BY4743 could also be used to investigate this oscillatory phenomenon, which traditionally has been studied using <jats:italic>S. cerevisiae<\/jats:italic> X2180. This has enabled us to employ existing isogenic deletion mutants and dissect the roles of isoforms, or subunits of key glycolytic enzymes in glycolytic oscillations. We demonstrate that deletion of <jats:italic>TDH3<\/jats:italic> but not <jats:italic>TDH2<\/jats:italic> and <jats:italic>TDH1<\/jats:italic> (encoding glyceraldehyde-3-phosphate dehydrogenase: GAPDH) abolishes NADH oscillations. While deletion of each of the hexokinase (HK) encoding genes (<jats:italic>HXK1<\/jats:italic> and <jats:italic>HXK2<\/jats:italic>) leads to oscillations that are longer lasting with lower amplitude, the effect of <jats:italic>HXK2<\/jats:italic> deletion on the duration of the oscillations is stronger than that of <jats:italic>HXK1<\/jats:italic>. Most importantly our results show that the presence of beta (Pfk2) but not that of alpha subunits (Pfk1) of the hetero-octameric enzyme phosphofructokinase (PFK) is necessary to achieve these oscillations. Furthermore, we report that the cAMP-mediated PKA pathway (via some of its components responsible for feedback down-regulation) modulates the activity of glycoytic enzymes thus affecting oscillations. Deletion of both <jats:italic>PDE2<\/jats:italic> (encoding a high affinity cAMP-phosphodiesterase) and <jats:italic>IRA2<\/jats:italic> (encoding a GTPase activating protein- Ras-GAP, responsible for inactivating Ras-GTP) abolished glycolytic oscillations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The genetic approach to characterising the glycolytic oscillations in yeast has demonstrated differential roles of the two types of subunits of PFK, and the isoforms of GAPDH and HK. Furthermore, it has shown that <jats:italic>PDE2<\/jats:italic> and <jats:italic>IRA2<\/jats:italic>, encoding components of the cAMP pathway responsible for negative feedback regulation of PKA, are required for glycolytic oscillations, suggesting an enticing link between these cAMP pathway components and the glycolysis pathway enzymes shown to have the greatest role in glycolytic oscillation. This study suggests that a systematic genetic approach combined with mathematical modelling can advance the study of oscillatory phenomena.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-6-108","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T10:14:28Z","timestamp":1345803268000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exploring the genetic control of glycolytic oscillations in Saccharomyces Cerevisiae"],"prefix":"10.1186","volume":"6","author":[{"given":"Thomas","family":"Williamson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delali","family":"Adiamah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubomira","family":"Stateva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"964_CR1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/(SICI)1097-0061(19960630)12:8<731::AID-YEA961>3.0.CO;2-Z","volume":"12","author":"P Richard","year":"1996","unstructured":"Richard P, Teusink B, Hemker MB, Van Dam K, Westerhoff HV: Sustained oscillations in free-energy state and hexose phosphates in yeast. 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