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However, when stomata are presented with a combination of both signals, they fail to close.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Toshed light on this unexplained behaviour, we have collected time course measurements of stomatal aperture and hydrogen peroxide production in<jats:italic>Arabidopsis thaliana<\/jats:italic>guard cells treated with abscisic acid, ethylene, and a combination of both. Our experiments show that stomatal closure is linked to sustained high levels of hydrogen peroxide in guard cells. When treated with a combined dose of abscisic acid and ethylene, guard cells exhibit increased antioxidant activity that reduces hydrogen peroxide levels and precludes closure. We construct a simplified model of stomatal closure derived from known biochemical pathways that captures the experimentally observed behaviour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our experiments and modelling results suggest a distinct role for two antioxidant mechanisms during stomatal closure: a slower, delayed response activated by a single stimulus (abscisic acid \u2018or\u2019 ethylene) and another more rapid \u2018and\u2019 mechanism that is only activated when both stimuli are present. Our model indicates that the presence of this rapid \u2018and\u2019 mechanism in the antioxidant response is key to explain the lack of closure under a combined stimulus.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-0509-6-146","type":"journal-article","created":{"date-parts":[[2012,11,25]],"date-time":"2012-11-25T19:14:07Z","timestamp":1353870847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Compound stress response in stomatal closure: a mathematical model of ABA and ethylene interaction in guard cells"],"prefix":"10.1186","volume":"6","author":[{"given":"Mariano","family":"Beguerisse-D\u0131az","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MercedesC","family":"Hern\u00e1ndez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AlessandroM","family":"Lizzul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Barahona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Desikan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,25]]},"reference":[{"key":"1037_CR1","volume-title":"Plant Physiology","author":"L Taiz","year":"2002","unstructured":"Taiz L, Zeiger E: Plant Physiology. 2002, Sunderland: Sinauer Associates, Inc"},{"key":"1037_CR2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1146\/annurev.arplant.52.1.627","volume":"52","author":"JI Schroeder","year":"2001","unstructured":"Schroeder JI, Allen GJ, Hugouvieux V, Kwak JM, Waner D: Guard cell signal transduction. 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