{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:26:04Z","timestamp":1747387564584},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"S1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Alternative splicing is a ubiquitous gene regulatory mechanism that dramatically increases the complexity of the proteome. However, the mechanism for regulating alternative splicing is poorly understood, and study of coordinated splicing regulation has been limited to individual cases. To study genome-wide splicing regulation, we integrate many human RNA-seq datasets to identify splicing module, which we define as a set of cassette exons co-regulated by the same splicing factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We have designed a tensor-based approach to identify co-splicing clusters that appear frequently across multiple conditions, thus very likely to represent splicing modules - a unit in the splicing regulatory network. In particular, we model each RNA-seq dataset as a co-splicing network, where the nodes represent exons and the edges are weighted by the correlations between exon inclusion rate profiles. We apply our tensor-based method to the 38 co-splicing networks derived from human RNA-seq datasets and indentify an atlas of frequent co-splicing clusters. We demonstrate that these identified clusters represent potential splicing modules by validating against four biological knowledge databases. The likelihood that a frequent co-splicing cluster is biologically meaningful increases with its recurrence across multiple datasets, highlighting the importance of the integrative approach.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Co-splicing clusters reveal novel functional groups which cannot be identified by co-expression clusters, particularly they can grant new insights into functions associated with post-transcriptional regulation, and the same exons can dynamically participate in different pathways depending on different conditions and different other exons that are co-spliced. We propose that by identifying splicing module, a unit in the splicing regulatory network can serve as an important step to decipher the splicing code.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-6-s1-s17","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T22:19:18Z","timestamp":1354745958000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Integrating many co-splicing networks to reconstruct splicing regulatory modules"],"prefix":"10.1186","volume":"6","author":[{"given":"Chao","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghong Jasmine","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"issue":"7221","key":"886_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature07509","volume":"456","author":"ET Wang","year":"2008","unstructured":"Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB: Alternative isoform regulation in human tissue transcriptomes. Nature. 2008, 456 (7221): 470-476. 10.1038\/nature07509.","journal-title":"Nature"},{"issue":"5","key":"886_CR2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/nrm1645","volume":"6","author":"AJ Matlin","year":"2005","unstructured":"Matlin AJ, Clark F, Smith CWJ: Understanding alternative splicing: towards a cellular code. Nat Rev Mol Cell Biol. 2005, 6 (5): 386-398. 10.1038\/nrm1645.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"886_CR3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2777","volume":"10","author":"M Chen","year":"2009","unstructured":"Chen M, Manley JL: Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol. 2009, 10 (11): 741-754.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"886_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0092-8674(88)90384-4","volume":"53","author":"R Nagoshi","year":"1988","unstructured":"Nagoshi R, McKeown M, Burtis K, Belote J, Baker B: The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell. 1988, 53 (2): 229-236. 10.1016\/0092-8674(88)90384-4.","journal-title":"Cell"},{"issue":"4","key":"886_CR5","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/0092-8674(91)90090-L","volume":"65","author":"M Hedley","year":"1991","unstructured":"Hedley M, Maniatis T: Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell. 1991, 65 (4): 579-586. 10.1016\/0092-8674(91)90090-L.","journal-title":"Cell"},{"issue":"8","key":"886_CR6","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/ng1610","volume":"37","author":"A Jernej Ule","year":"2005","unstructured":"Jernej Ule A, Ule J, Alan Williams J, Melissa Cline H, Tyson Clark C, Matteo Ruggiu B, David Kane J, John Blume R: Nova regulates brain-specific splicing to shape the synapse. Nature Genetics. 2005, 37 (8): 844-852. 10.1038\/ng1610.","journal-title":"Nature Genetics"},{"issue":"16","key":"886_CR7","doi-asserted-by":"publisher","first-page":"8175","DOI":"10.1073\/pnas.93.16.8175","volume":"93","author":"M Hentze","year":"1996","unstructured":"Hentze M, Kuhn L: Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 1996, 93 (16): 8175-82. 10.1073\/pnas.93.16.8175.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"18","key":"886_CR8","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1101\/gad.1703108","volume":"22","author":"C Zhang","year":"2008","unstructured":"Zhang C, Zhang Z, Castle J, Sun S, Johnson J, Krainer A, Zhang M: Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes & Development. 2008, 22 (18): 2550-2563. 10.1101\/gad.1703108.","journal-title":"Genes & Development"},{"issue":"4","key":"886_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.cell.2010.07.019","volume":"142","author":"M Moore","year":"2010","unstructured":"Moore M, Wang Q, Kennedy C, Silver P: An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis. Cell. 2010, 142 (4): 625-636. 10.1016\/j.cell.2010.07.019.","journal-title":"Cell"},{"key":"886_CR10","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1186\/gb-2009-10-1-r3","volume":"10","author":"L Chen","year":"2009","unstructured":"Chen L, Zheng S: Studying alternative splicing regulatory networks through partial correlation analysis. Genome biology. 2009, 10: R3-10.1186\/gb-2009-10-1-r3.","journal-title":"Genome biology"},{"issue":"13","key":"886_CR11","doi-asserted-by":"publisher","first-page":"i577","DOI":"10.1093\/bioinformatics\/btm227","volume":"23","author":"X Yan","year":"2007","unstructured":"Yan X, Mehan M, Huang Y, Waterman M, Yu P, Zhou X: A graph-based approach to systematically reconstruct human transcriptional regulatory modules. Bioinformatics. 2007, 23 (13): i577-10.1093\/bioinformatics\/btm227.","journal-title":"Bioinformatics"},{"issue":"6","key":"886_CR12","doi-asserted-by":"publisher","first-page":"e1001106","DOI":"10.1371\/journal.pcbi.1001106","volume":"7","author":"W Li","year":"2011","unstructured":"Li W, Liu CC, Zhang T, Li H, Waterman MS, Zhou XJ: Integrative Analysis of Many Weighted Co-Expression Networks Using Tensor Computation. PLoS Comput Biol. 2011, 7 (6): e1001106-","journal-title":"PLoS Comput Biol"},{"issue":"8","key":"886_CR13","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1073\/pnas.79.8.2554","volume":"79","author":"JJ Hopfield","year":"1982","unstructured":"Hopfield JJ: Neural networks and physical systems with emergent collective computational abilities. Proc Natl Acad Sci USA. 1982, 79 (8): 2554-2558. 10.1073\/pnas.79.8.2554.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"886_CR14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.4153\/CJM-1965-053-6","volume":"17","author":"TS Motzkin","year":"1965","unstructured":"Motzkin TS, Straus EG: Maxima for Graphs and a New Proof of a Theorem of Tur\u00e1n. Canadian Journal of Mathematics. 1965, 17 (4): 533-540.","journal-title":"Canadian Journal of Mathematics"},{"issue":"9","key":"886_CR15","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL: TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009, 25 (9): 1105-1111. 10.1093\/bioinformatics\/btp120.","journal-title":"Bioinformatics"},{"issue":"5","key":"886_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","volume":"28","author":"C Trapnell","year":"2010","unstructured":"Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ, Pachter L: Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nature Biotechnology. 2010, 28 (5): 511-515. 10.1038\/nbt.1621.","journal-title":"Nature Biotechnology"},{"key":"886_CR17","doi-asserted-by":"publisher","first-page":"D876","DOI":"10.1093\/nar\/gkq963","volume":"39","author":"PA Fujita","year":"2011","unstructured":"Fujita PA, Rhead B, Zweig AS, Hinrichs AS, Karolchik D, Cline MS, Goldman M, Barber GP, Clawson H, Coelho A, Diekhans M, Dreszer TR, Giardine BM, Harte RA, Hillman-Jackson J, Hsu F, Kirkup V, Kuhn RM, Learned K, Li CH, Meyer LR, Pohl A, Raney BJ, Rosenbloom KR, Smith KE, Haussler D, Kent WJ: The UCSC Genome Browser database: update 2011. Nucleic Acids Research. 2011, 39: D876-882. 10.1093\/nar\/gkq963.","journal-title":"Nucleic Acids Research"},{"issue":"8","key":"886_CR18","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/bioinformatics\/btp113","volume":"25","author":"H Jiang","year":"2009","unstructured":"Jiang H, Wong WH: Statistical inferences for isoform expression in RNA-Seq. Bioinformatics. 2009, 25 (8): 1026-1032. 10.1093\/bioinformatics\/btp113.","journal-title":"Bioinformatics"},{"issue":"7221","key":"886_CR19","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/nature07488","volume":"456","author":"DD Licatalosi","year":"2008","unstructured":"Licatalosi DD, Mele A, Fak JJ, Ule J, Kayikci M, Chi SW, Clark TA, Schweitzer AC, Blume JE, Wang X, Darnell JC, Darnell RB: HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature. 2008, 456 (7221): 464-469. 10.1038\/nature07488.","journal-title":"Nature"},{"key":"886_CR20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/humu.21609","volume":"33","author":"F Piva","year":"2012","unstructured":"Piva F, Giulietti M, Burini AB, Principato G: SpliceAid 2: A database of human splicing factors expression data and RNA target motifs. Hum Mutat. 2012, 33: 81-85. 10.1002\/humu.21609.","journal-title":"Hum Mutat"},{"issue":"15","key":"886_CR21","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1038\/sj.emboj.7600745","volume":"24","author":"CR Rothrock","year":"2005","unstructured":"Rothrock CR, House AE, Lynch KW: HnRNP L represses exon splicing via a regulated exonic splicing silencer. The EMBO Journal. 2005, 24 (15): 2792-2802. 10.1038\/sj.emboj.7600745.","journal-title":"The EMBO Journal"},{"issue":"10","key":"886_CR22","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/sj.onc.1209922","volume":"26","author":"L Spraggon","year":"2007","unstructured":"Spraggon L, Dudnakova T, Slight J, Lustig-Yariv O, Cotterell J, Hastie N, Miles C: hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation. Oncogene. 2007, 26 (10): 1484-1491. 10.1038\/sj.onc.1209922.","journal-title":"Oncogene"},{"issue":"11","key":"886_CR23","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1002\/j.1460-2075.1994.tb06554.x","volume":"13","author":"Y Cavaloc","year":"1994","unstructured":"Cavaloc Y, Popielarz M, Fuchs JP, Gattoni R, St\u00e9venin J: Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine\/arginine protein family. The EMBO Journal. 1994, 13 (11): 2639-2649.","journal-title":"The EMBO Journal"},{"issue":"8","key":"886_CR24","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/nsmb.1862","volume":"17","author":"M Ank\u00f6","year":"2010","unstructured":"Ank\u00f6 M, Morales L, Henry I, Beyer A, Neugebauer KM: Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Nature Structural & Molecular Biology. 2010, 17 (8): 962-970. 10.1038\/nsmb.1862.","journal-title":"Nature Structural & Molecular Biology"},{"issue":"12","key":"886_CR25","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1128\/MCB.22.12.4001-4010.2002","volume":"22","author":"MJ Simard","year":"2002","unstructured":"Simard MJ, Chabot B: SRp30c is a repressor of 3' splice site utilization. Molecular and Cellular Biology. 2002, 22 (12): 4001-4010. 10.1128\/MCB.22.12.4001-4010.2002.","journal-title":"Molecular and Cellular Biology"},{"key":"886_CR26","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1074\/jbc.M505814200","volume":"281","author":"E Park","year":"2006","unstructured":"Park E, Han J, Son GH, Lee MS, Chung S, Park SH, Park K, Lee KH, Choi S, Seong JY, Kim K: Cooperative actions of Tra2\u03b1 with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript. The Journal of Biological Chemistry. 2006, 281: 401-409.","journal-title":"The Journal of Biological Chemistry"},{"key":"886_CR27","doi-asserted-by":"publisher","first-page":"D663","DOI":"10.1093\/nar\/gkl1017","volume":"35","author":"DJ Thomas","year":"2007","unstructured":"Thomas DJ, Rosenbloom KR, Clawson H, Hinrichs AS, Trumbower H, Raney BJ, Karolchik D, Barber GP, Harte RA, Hillman-Jackson J, Kuhn RM, Rhead BL, Smith KE, Thakkapallayil A, Zweig AS, Haussler D, Kent WJ: The ENCODE Project at UC Santa Cruz. Nucleic Acids Res. 2007, 35: D663-D667. 10.1093\/nar\/gkl1017.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"886_CR28","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1073\/pnas.89.3.1060","volume":"89","author":"M Horikoshi","year":"1992","unstructured":"Horikoshi M, Bertuccioli C, Takada R, Wang J, Yamamoto T, Roeder RG: Transcription factor TFIID induces DNA bending upon binding to the TATA element. Proceedings of the National Academy of Sciences of the United States of America. 1992, 89 (3): 1060-1064. 10.1073\/pnas.89.3.1060.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"886_CR29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bcmd.2003.09.005","volume":"32","author":"AG Rosmarin","year":"2004","unstructured":"Rosmarin AG, Resendes KK, Yang Z, McMillan JN, Fleming SL: GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions. Blood Cells Mol Dis. 2004, 32: 143-154. 10.1016\/j.bcmd.2003.09.005.","journal-title":"Blood Cells Mol Dis"},{"issue":"4","key":"886_CR30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0197-0186(98)00023-0","volume":"33","author":"KJ Kov\u00e1cs","year":"1998","unstructured":"Kov\u00e1cs KJ: c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochemistry International. 1998, 33 (4): 287-297. 10.1016\/S0197-0186(98)00023-0.","journal-title":"Neurochemistry International"},{"issue":"3","key":"886_CR31","doi-asserted-by":"publisher","first-page":"e17220","DOI":"10.1371\/journal.pone.0017220","volume":"6","author":"A Fossati","year":"2011","unstructured":"Fossati A, Dolfini D, Donati G, Mantovani R: NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters. PloS One. 2011, 6 (3): e17220-10.1371\/journal.pone.0017220.","journal-title":"PloS One"},{"key":"886_CR32","doi-asserted-by":"publisher","first-page":"D497","DOI":"10.1093\/nar\/gkp914","volume":"38","author":"A Ruepp","year":"2010","unstructured":"Ruepp A, Waegele B, Lechner M, Brauner B, Dunger-Kaltenbach I, Fobo G, Frishman G, Montrone C, Mewes H: CORUM: the comprehensive resource of mammalian protein complexes-2009. Nucleic Acids Res. 2010, 38: D497-D501. 10.1093\/nar\/gkp914.","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"886_CR33","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.molcel.2004.12.004","volume":"16","author":"Q Pan","year":"2004","unstructured":"Pan Q, Shai O, Misquitta C, Zhang W, Saltzman AL, Mohammad N, Babak T, Siu H, Hughes TR, Morris QD, Frey BJ, Blencowe BJ: Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Molecular Cell. 2004, 16 (6): 929-941. 10.1016\/j.molcel.2004.12.004.","journal-title":"Molecular Cell"},{"issue":"6","key":"886_CR34","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nsmb1092","volume":"13","author":"TR Hartman","year":"2006","unstructured":"Hartman TR, Qian S, Bolinger C, Fernandez S, Schoenberg DR, Boris-Lawrie K: RNA helicase A is necessary for translation of selected messenger RNAs. Nat Struct Mol Biol. 2006, 13 (6): 509-516. 10.1038\/nsmb1092.","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"886_CR35","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1365-2958.1992.tb01470.x","volume":"6","author":"SR Schmid","year":"1992","unstructured":"Schmid SR, Linder P: D-E-A-D protein family of putative RNA helicases. Molecular Microbiology. 1992, 6 (3): 283-291. 10.1111\/j.1365-2958.1992.tb01470.x.","journal-title":"Molecular Microbiology"},{"issue":"6","key":"886_CR36","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0092-8674(00)80376-1","volume":"90","author":"T Nakajima","year":"1997","unstructured":"Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD, Montminy M: RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 1997, 90 (6): 1107-1112. 10.1016\/S0092-8674(00)80376-1.","journal-title":"Cell"},{"key":"886_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkg933","volume":"32","author":"S Zhang","year":"2004","unstructured":"Zhang S, Schlott B, G\u00f6rlach M, Grosse F: DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II\/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Research. 2004, 32: 1-10. 10.1093\/nar\/gkg933.","journal-title":"Nucleic Acids Research"},{"key":"886_CR38","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ncomms1103","volume":"1","author":"AP Dias","year":"2010","unstructured":"Dias AP, Dufu K, Lei H, Reed R: A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nature Communications. 2010, 1: 97-10.1038\/ncomms1103.","journal-title":"Nature Communications"},{"issue":"2","key":"886_CR39","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.gene.2008.07.015","volume":"423","author":"JR Leeman","year":"2008","unstructured":"Leeman JR, Gilmore TD: Alternative splicing in the NF-kappaB signaling pathway. Gene. 2008, 423 (2): 97-107. 10.1016\/j.gene.2008.07.015.","journal-title":"Gene"},{"issue":"14","key":"886_CR40","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1021\/bi052387u","volume":"45","author":"MR Conte","year":"2006","unstructured":"Conte MR, Kelly G, Babon J, Sanfelice D, Youell J, Smerdon SJ, Proud CG: Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. Biochemistry. 2006, 45 (14): 4550-4558. 10.1021\/bi052387u.","journal-title":"Biochemistry"},{"key":"886_CR41","first-page":"1081","volume":"11","author":"T Zhang","year":"2010","unstructured":"Zhang T: Analysis of Multi-stage Convex Relaxation for Sparse Regularization. J Mach Learn Res. 2010, 11: 1081-1107.","journal-title":"J Mach Learn Res"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-6-S1-S17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T19:13:12Z","timestamp":1630523592000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-6-S1-S17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":41,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["886"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-6-s1-s17","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"16 July 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"S17"}}