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Therefore, we hoped to reveal that it is feasible and useful to compare gene expression profiles across species in the studies of pathology, toxicology, drug repositioning, and drug action mechanism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We developed a cross-species analysis method to analyze animal models' similarity to human diseases and effectiveness in drug research by utilizing the existing animal gene expression data in the public database, and mined some meaningful information to help drug research, such as potential drug candidates, possible drug repositioning, side effects and analysis in pharmacology. New animal models could be evaluated by our method before they are used in drug discovery.<\/jats:p>\n            <jats:p>We applied the method to several cases of known animal model expression profiles and obtained some useful information to help drug research. We found that trichostatin A and some other HDACs could have very similar response across cell lines and species at gene expression level. Mouse hypoxia model could accurately mimic the human hypoxia, while mouse diabetes drug model might have some limitation. The transgenic mouse of Alzheimer was a useful model and we deeply analyzed the biological mechanisms of some drugs in this case. In addition, all the cases could provide some ideas for drug discovery and drug repositioning.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We developed a new cross-species gene expression module comparison method to use animal models' expression data to analyse the effectiveness of animal models in drug research. Moreover, through data integration, our method could be applied for drug research, such as potential drug candidates, possible drug repositioning, side effects and information about pharmacology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-6-s3-s18","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T13:15:03Z","timestamp":1355750103000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A cross-species analysis method to analyze animal models' similarity to human's disease state"],"prefix":"10.1186","volume":"6","author":[{"given":"Shuhao","family":"Yu","sequence":"first","affiliation":[]},{"given":"Lulu","family":"Zheng","sequence":"additional","affiliation":[]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[]},{"given":"Chenchen","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Yixue","family":"Li","sequence":"additional","affiliation":[]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[]},{"given":"Pei","family":"Hao","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"issue":"3","key":"1003_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nm.1912","volume":"15","author":"AH Nagahara","year":"2009","unstructured":"Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, et al: Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. 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