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However, the majority of these models are still created <jats:italic>de novo<\/jats:italic>, based on literature mining and the manual processing of pathway data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>To increase the efficiency of model creation, the Path2Models project has automatically generated mathematical models from pathway representations using a suite of freely available software. Data sources include KEGG, BioCarta, MetaCyc and SABIO-RK. Depending on the source data, three types of models are provided: kinetic, logical and constraint-based. Models from over 2 600 organisms are encoded consistently in SBML, and are made freely available through BioModels Database at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ebi.ac.uk\/biomodels-main\/path2models\" ext-link-type=\"uri\">http:\/\/www.ebi.ac.uk\/biomodels-main\/path2models<\/jats:ext-link>. Each model contains the list of participants, their interactions, the relevant mathematical constructs, and initial parameter values. Most models are also available as easy-to-understand graphical SBGN maps.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>To date, the project has resulted in more than 140 000 freely available models. Such a resource can tremendously accelerate the development of mathematical models by providing initial starting models for simulation and analysis, which can be subsequently curated and further parameterized.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-7-116","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T10:05:54Z","timestamp":1383300354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Path2Models: large-scale generation of computational models from biochemical pathway maps"],"prefix":"10.1186","volume":"7","author":[{"given":"Finja","family":"B\u00fcchel","sequence":"first","affiliation":[]},{"given":"Nicolas","family":"Rodriguez","sequence":"additional","affiliation":[]},{"given":"Neil","family":"Swainston","sequence":"additional","affiliation":[]},{"given":"Clemens","family":"Wrzodek","sequence":"additional","affiliation":[]},{"given":"Tobias","family":"Czauderna","sequence":"additional","affiliation":[]},{"given":"Roland","family":"Keller","sequence":"additional","affiliation":[]},{"given":"Florian","family":"Mittag","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schubert","sequence":"additional","affiliation":[]},{"given":"Mihai","family":"Glont","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Golebiewski","sequence":"additional","affiliation":[]},{"given":"Martijn","family":"van Iersel","sequence":"additional","affiliation":[]},{"given":"Sarah","family":"Keating","sequence":"additional","affiliation":[]},{"given":"Matthias","family":"Rall","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Wybrow","sequence":"additional","affiliation":[]},{"given":"Henning","family":"Hermjakob","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Hucka","sequence":"additional","affiliation":[]},{"given":"Douglas B","family":"Kell","sequence":"additional","affiliation":[]},{"given":"Wolfgang","family":"M\u00fcller","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Zell","sequence":"additional","affiliation":[]},{"given":"Claudine","family":"Chaouiya","sequence":"additional","affiliation":[]},{"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[]},{"given":"Falk","family":"Schreiber","sequence":"additional","affiliation":[]},{"given":"Camille","family":"Laibe","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Dr\u00e4ger","sequence":"additional","affiliation":[]},{"given":"Nicolas","family":"Le Nov\u00e8re","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"1200_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/nar\/28.1.56","volume":"28","author":"PD Karp","year":"2000","unstructured":"Karp PD, Riley M, Saier M, Paulsen IT, Paley SM, Pellegrini-Toole A: The EcoCyc and MetaCyc databases. 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