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Furthermore, available implementations cannot easily be extended or adapted by users.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Here, we present sybil, an open source software library for constraint-based analyses in R; R is a free, platform-independent environment for statistical computing and graphics that is widely used in bioinformatics. Among other functions, sybil currently provides efficient methods for flux-balance analysis (FBA), MOMA, and ROOM that are about ten times faster than previous implementations when calculating the effect of whole-genome single gene deletions <jats:italic>in silico<\/jats:italic> on a complete <jats:italic>E. coli<\/jats:italic> metabolic model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Due to the object-oriented architecture of sybil, users can easily build analysis pipelines in R or even implement their own constraint-based algorithms. Based on its highly efficient communication with different mathematical optimisation programs, sybil facilitates the exploration of high-dimensional optimisation problems on small time scales. Sybil and all its dependencies are open source. Sybil and its documentation are available for download from the comprehensive R archive network (CRAN).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-7-125","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T10:07:20Z","timestamp":1384337240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["sybil \u2013 Efficient constraint-based modelling in R"],"prefix":"10.1186","volume":"7","author":[{"given":"Gabriel","family":"Gelius-Dietrich","sequence":"first","affiliation":[]},{"given":"Abdelmoneim Amer","family":"Desouki","sequence":"additional","affiliation":[]},{"given":"Claus Jonathan","family":"Fritzemeier","sequence":"additional","affiliation":[]},{"given":"Martin J","family":"Lercher","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"issue":"5","key":"1205_CR1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.copbio.2003.08.001","volume":"14","author":"KJ Kauffman","year":"2003","unstructured":"Kauffman KJ, Prakash P, Edwards JS: Advances in flux balance analysis. 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