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Here we present the analysis of the ordered cascade of the AgMNPV gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed an earlier onset of the expression than previously reported for other baculoviruses, especially for genes involved in DNA replication. Most ORFs were expressed at higher levels in a more permissive host cell line. Genes with more than one copy in the genome had distinct expression profiles, which could indicate the acquisition of new functionalities. The transcription gene regulatory network (GRN) for 149 ORFs had a modular topology comprising five communities of highly interconnected nodes that separated key genes that are functionally related on different communities, possibly maximizing redundancy and GRN robustness by compartmentalization of important functions. Core conserved functions showed expression synchronicity, distinct GRN features and significantly less genetic diversity, consistent with evolutionary constraints imposed in key elements of biological systems. This reduced genetic diversity also had a positive correlation with the importance of the gene in our estimated GRN, supporting a relationship between phylogenetic data of baculovirus genes and network features inferred from expression data. We also observed that gene arrangement in overlapping transcripts was conserved among related baculoviruses, suggesting a principle of genome organization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Albeit with a reduced number of nodes (149), the AgMNPV GRN had a topology and key characteristics similar to those observed in complex cellular organisms, which indicates that modularity may be a general feature of biological gene regulatory networks.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-0509-7-87","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T16:18:38Z","timestamp":1378311518000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modularity and evolutionary constraints in a baculovirus gene regulatory network"],"prefix":"10.1186","volume":"7","author":[{"given":"Juliana Velasco","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Anderson Fernandes","family":"de Brito","sequence":"additional","affiliation":[]},{"given":"Carla Torres","family":"Braconi","sequence":"additional","affiliation":[]},{"given":"Caio C\u00e9sar","family":"de Melo Freire","sequence":"additional","affiliation":[]},{"given":"Atila","family":"Iamarino","sequence":"additional","affiliation":[]},{"given":"Paolo Marinho","family":"de Andrade Zanotto","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"1440_CR1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nrg1471","volume":"5","author":"H Kitano","year":"2004","unstructured":"Kitano H: Biological robustness. 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