{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:46:25Z","timestamp":1696545985800},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>An important aspect of molecular interactions is the dynamics associated with growth conditions. Intuitively, not all possible interactions take place together all the time in a cell as only a subset of genes is expressed based on environmental conditions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Large scale gene expression data of <jats:italic>Escherichia coli<\/jats:italic> was analyzed to understand the dynamics exhibited at expression level. A large compendium of gene expression datasets, which covers about 466 growth conditions, was used for the analysis. Using gene expression data, genes of <jats:italic>E. coli<\/jats:italic> were profiled into three classes: Widely expressed, Conditionally expressed and Rarely expressed. Further, dynamics associated with molecular interactions were analysed by studying changing importance of motifs in the composite networks across growth conditions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our analysis of large scale gene expression data suggests conditional expression of genes which brings about befitting responses for a given growth environment. We observe a range of importance for network motifs across conditions which can be correlated with a specific function. Our study therefore suggests rewiring of molecular interactions driven by gene expression changes depending on the conditional needs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-8-26","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T12:02:57Z","timestamp":1393502577000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differential enrichment of regulatory motifs in the composite network of protein-protein and gene regulatory interactions"],"prefix":"10.1186","volume":"8","author":[{"given":"Shubhada R","family":"Hegde","sequence":"first","affiliation":[]},{"given":"Khushbu","family":"Pal","sequence":"additional","affiliation":[]},{"given":"Shekhar C","family":"Mande","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"1292_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrg1272","volume":"5","author":"AL Barab\u00e1si","year":"2004","unstructured":"Barab\u00e1si AL, Oltvai ZN: Network biology: understanding the cell\u2019s functional organization. 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