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Here, we propose a simple methodology that first performs an enrichment test to find patterns in the values of globally profiled kinetic parameters with which a model can produce the required system dynamics; this is then followed by a statistical test to elucidate the association between individual parameters and different parts of the system\u2019s dynamics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We demonstrate our methodology on a prototype biological system of perfect adaptation dynamics, namely the chemotaxis model for <jats:italic>Escherichia coli<\/jats:italic>. Our results agreed well with those derived from experimental data and theoretical studies in the literature. Using this model system, we showed that there are motifs in kinetic parameters and that these motifs are governed by constraints of the specified system dynamics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>A systematic approach based on enrichment statistical tests has been developed to elucidate the relationships between model parameters and the roles they play in affecting system dynamics of a prototype biological network. The proposed approach is generally applicable and therefore can find wide use in systems biology modeling research.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-8-4","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T18:30:31Z","timestamp":1389810631000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters"],"prefix":"10.1186","volume":"8","author":[{"given":"Austin WT","family":"Chiang","sequence":"first","affiliation":[]},{"given":"Wei-Chung","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Pep","family":"Charusanti","sequence":"additional","affiliation":[]},{"given":"Ming-Jing","family":"Hwang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"1262_CR1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1146\/annurev.genom.2.1.343","volume":"2","author":"T Ideker","year":"2001","unstructured":"Ideker T, Galitski T, Hood L: A new approach to decoding life: systems biology. 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