{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:27:21Z","timestamp":1792330041822,"version":"4.4.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chemistry Central Journal"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The goal of our study was to evaluate the effects of different medicinal herbs rich in polyphenol (Lemon balm, Sage, St. John's wort and Small-flowered Willowherb) used as dietary supplements on bioaccumulation of some essential metals (Fe, Mn, Zn and Cu) in different chicken meats (liver, legs and breast).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In different type of chicken meats (liver, legs and breast) from chickens fed with diets enriched in minerals and medicinal herbs, beneficial metals (Fe, Mn, Zn and Cu) were analysed by flame atomic absorption spectrometry. Fe is the predominant metal in liver and Zn is the predominant metal in legs and breast chicken meats. The addition of metal salts in the feed influences the accumulations of all metals in the liver, legs and breast chicken meat with specific difference to the type of metal and meat. The greatest influences were observed in legs meat for Fe and Mn. Under the influence of polyphenol-rich medicinal herbs, accumulation of metals in the liver, legs and breast chicken meat presents specific differences for each medicinal herb, to the control group that received a diet supplemented with metal salts only. Great influence on all metal accumulation factors was observed in diet enriched with sage, which had significantly positive effect for all type of chicken meats.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Under the influence of medicinal herbs rich in different type of polyphenol, accumulation of metals in the liver, legs and breast chicken meat presents significant differences from the group that received a diet supplemented only with metal salts. Each medicinal herb from diet had a specific influence on the accumulation of metals and generally moderate or poor correlations were observed between total phenols and accumulation of metals. This may be due to antagonism between metal ions and presence of other chelating agents (amino acids and protein) from feeding diets which can act as competitor for complexation of metals and influence accumulation of metals in chicken meat.<\/jats:p>\n            <jats:p>\n              <jats:bold>Graphical abstract<\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-153x-6-19","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T21:17:19Z","timestamp":1332191839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of mineral-enriched diet and medicinal herbs on Fe, Mn, Zn, and Cu uptake in chicken"],"prefix":"10.1186","volume":"6","author":[{"given":"Ducu Sandu","family":"Stef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iosif","family":"Gergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"377_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3923\/pjn.2003.98.101","volume":"2","author":"SM Sabir","year":"2003","unstructured":"Sabir SM, Khan SW, Hayat I: Effect of environmental pollution on quality of meat in district Bagh, Azad Kashmir. Pakistan Journal of Nutrition. 2003, 2: 98-101.","journal-title":"Pakistan Journal of Nutrition"},{"key":"377_CR2","first-page":"610","volume":"9","author":"K Birla Singh","year":"2010","unstructured":"Birla Singh K, Taneja SK: Concentration of Zn, Cu and Mn in vegetables and meat foodstuffs commonly available in Manipur: a North Eastern state of India. EJEAFChe. 2010, 9: 610-616.","journal-title":"EJEAFChe"},{"key":"377_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1752-153X-5-64","volume":"5","author":"M Harmanescu","year":"2011","unstructured":"Harmanescu M, Alda LM, Bordean DM, Gogoasa I, Gergen I: Heavy metals health risk assessment for population via consumption of vegetables grown in old mining area; a case study: Banat County Romania. Chem Centr J. 2011, 5: 64-10.1186\/1752-153X-5-64.","journal-title":"Chem Centr J"},{"issue":"3","key":"377_CR4","first-page":"6242","volume":"16","author":"M Murariu","year":"2011","unstructured":"Murariu M, Gradinaru RV, Mihai M, Jurcoane S, Drochioiu G: Unexpected effect of nickel complexes of some histidine-containing peptides on Escherichia coli. Romanian Biotechnological Letters. 2011, 16 (3): 6242-6246.","journal-title":"Romanian Biotechnological Letters"},{"key":"377_CR5","first-page":"30","volume":"44","author":"D Drinceanu","year":"2011","unstructured":"Drinceanu D, Julean C, Simiz E, \u015etef L, Luca I, Sofian D: Effects of mineral supplements on bioproductive results in egg-laying hens farmed in organic systems. Scientific Papers: Animal Science and Biotechnologies. 2011, 44: 30-36.","journal-title":"Scientific Papers: Animal Science and Biotechnologies"},{"key":"377_CR6","first-page":"494","volume":"7","author":"R Abdulkarimi","year":"2011","unstructured":"Abdulkarimi R, Abdullahi A, Amini M: Mentha extract consumption (Mentha piperita L) reduced blood iron concentration and increased TIBC levels in broiler chickens. Journal of American Science. 2011, 7: 494-500.","journal-title":"Journal of American Science"},{"key":"377_CR7","first-page":"63","volume":"2","author":"COB Okoye","year":"2011","unstructured":"Okoye COB, Ibeto CN, Ihedioha JN: Assessment of heavy metals in chicken feeds sold in south eastern, Nigeria. Advances in Applied Science Research. 2011, 2: 63-68.","journal-title":"Advances in Applied Science Research"},{"key":"377_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1255\/ejms.1092","volume":"16","author":"M Murariu","year":"2010","unstructured":"Murariu M, Dragan ES, Drochioiu G: Electrospray ionization mass spectrometric approach of conformationally-induced metal binding to oligopeptides. Eur J Mass Spectrom. 2010, 16: 511-10.1255\/ejms.1092.","journal-title":"Eur J Mass Spectrom"},{"issue":"1-2","key":"377_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bpc.2009.05.008","volume":"144","author":"G Drochioiu","year":"2009","unstructured":"Drochioiu G, Manea M, Dragusanu M, Murariu M, Dragan ES, Petre BA, Mezo G, Przybylski M: Interaction of beta-amyloid(1-40) peptide with pairs of metal ions: An electrospray ion trap mass spectrometric model study. Biophys Chem. 2009, 144 (1-2): 9-20. 10.1016\/j.bpc.2009.05.008.","journal-title":"Biophys Chem"},{"key":"377_CR10","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1093\/japr\/16.3.448","volume":"16","author":"YM Bao","year":"2007","unstructured":"Bao YM, Choct M, Iji PA, Bruerton K: Effect of organically complexed Copper, Iron, Manganese and Zinc on broiler performance, mineral excretion and accumulation in tissues. J Appl Poult Res. 2007, 16: 448-455.","journal-title":"J Appl Poult Res"},{"key":"377_CR11","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3382\/japr.2006-00115","volume":"16","author":"L Nollet","year":"2007","unstructured":"Nollet L, van der Klis JD, Lensing M, Spring P: The effect of replacing inorganic with organic trace minerals in broiler diets on productive performance and mineral excretion. J Appl Poult Res Winter. 2007, 16: 592-597. 10.3382\/japr.2006-00115.","journal-title":"J Appl Poult Res Winter"},{"key":"377_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3923\/ijps.2009.291.298","volume":"8","author":"AG Abdallah","year":"2009","unstructured":"Abdallah AG, El-Husseiny OM, Abdel-Latif KO: Influence of some dietary organic mineral supplementations on broiler performance. International Journal of Poultry Science. 2009, 8: 291-298.","journal-title":"International Journal of Poultry Science"},{"key":"377_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/ps\/83.2.169","volume":"83","author":"F Hernandez","year":"2004","unstructured":"Hernandez F, Madrid J, Garc\u0131a V, Orengo J, Meg\u0131as MD: Influence of Two Plant Etracts on Broilers Performance, Digestibility, and Digestive Organ Size. Poultry Sci. 2004, 83: 169-174.","journal-title":"Poultry Sci"},{"key":"377_CR14","first-page":"4606","volume":"14","author":"L Stef","year":"2009","unstructured":"Stef L, Dumitrescu G, Drinceanu D, Stef D, Mot D, Julean C, Tetileanu R, Corcionivoschi N: The effect of medicinal plants and plant extracted oils on broiler duodenum morphology and immunological profile. Rom Biotechnol Lett. 2009, 14: 4606-4614.","journal-title":"Rom Biotechnol Lett"},{"key":"377_CR15","first-page":"1971","volume":"5","author":"F Khaligh","year":"2011","unstructured":"Khaligh F, Sadeghi G, Karimi A, Vaziry A: Evaluation of different medicinal plants blends in diets for broiler chickens. Journal of Medicinal Plants Research. 2011, 5: 1971-1977.","journal-title":"Journal of Medicinal Plants Research"},{"key":"377_CR16","first-page":"755","volume":"5","author":"AA Zaki","year":"2011","unstructured":"Zaki AA, Elbarawy AM, Darwish AS: Biochemical studies on the effect of Nasturtium Officinalis plant extract in chickens fed raw soya bean meals. Aust J Basic & Appl Sci. 2011, 5: 755-761.","journal-title":"Aust J Basic & Appl Sci"},{"key":"377_CR17","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.3382\/ps.2007-00506","volume":"87","author":"A Jang","year":"2008","unstructured":"Jang A, Liu XD, Shin MH, Lee BD, Lee SK, Lee JH, Jo C: Antioxidative potential of raw breast meat from broiler chicks fed a dietary medicinal herb extract mix. Poultry Sci. 2008, 87: 2382-2389. 10.3382\/ps.2007-00506.","journal-title":"Poultry Sci"},{"key":"377_CR18","doi-asserted-by":"publisher","first-page":"326","DOI":"10.5424\/sjar\/2010082-1199","volume":"8","author":"A Brenes","year":"2010","unstructured":"Brenes A, Viveros A, Go\u00f1i I, Centeno C, Saura-Calixto F, Arija I: Effect of grape seed extract on growth performance, protein and polyphenol digestibilities, and antioxidant activity in chickens. Span J Agric Res. 2010, 8: 326-333.","journal-title":"Span J Agric Res"},{"key":"377_CR19","first-page":"23","volume":"5","author":"U Polat","year":"2011","unstructured":"Polat U, Yesilbag D, Eren M: Serum biochemical profile of broiler chickens fed diets containing Rosemary and Rosemary volatile oil. J Biol Environ Sci. 2011, 5: 23-30.","journal-title":"J Biol Environ Sci"},{"key":"377_CR20","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.3390\/ijms10125485","volume":"10","author":"M Karama\u0107","year":"2009","unstructured":"Karama\u0107 M: Chelation of Cu(II), Zn(II), and Fe(II) by tannin constituents of selected edible nuts. Int J Mol Sci. 2009, 10: 5485-5497. 10.3390\/ijms10125485.","journal-title":"Int J Mol Sci"},{"key":"377_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0308-8146(02)00394-1","volume":"81","author":"S Khokhar","year":"2003","unstructured":"Khokhar S, Apenten RKO: Iron binding characteristics of phenolic compounds: some tentative structure-activity relations. Food Chem. 2003, 81: 133-140. 10.1016\/S0308-8146(02)00394-1.","journal-title":"Food Chem"},{"key":"377_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.foodchem.2005.05.044","volume":"98","author":"M Andjelkovi\u0107","year":"2006","unstructured":"Andjelkovi\u0107 M, Van Camp J, De Meulenaer B, Depaemelaere G, Socaciu C, Verloo M, Verhe R: Iron-chelation properties of phenolic acids bearing catechol and galloyl groups. Food Chem. 2006, 98: 23-31. 10.1016\/j.foodchem.2005.05.044.","journal-title":"Food Chem"},{"issue":"1","key":"377_CR23","first-page":"199","volume":"XI","author":"L Vargias","year":"2005","unstructured":"Vargias L, Harmanescu M, Gergen I: Mineral Content and Antioxidant Capacity of Aqueous and Methanolic Extract from Epilobium Hirsutum. Scientifical Researches. Agroalimentary Processes and Technologies. 2005, XI (1): 199-204.","journal-title":"Agroalimentary Processes and Technologies"},{"key":"377_CR24","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.chroma.2007.09.024","volume":"1171","author":"J Safra","year":"2007","unstructured":"Safra J, Posp\u00edsilov\u00e1 M, Honegr J, Spilkov\u00e1 J: Determination of selected antioxidants in Melissae herba by isotachophoresis and capillary zone electrophoresis in the column-coupling configuration. J Chromatogr A. 2007, 1171: 124-132. 10.1016\/j.chroma.2007.09.024.","journal-title":"J Chromatogr A"},{"key":"377_CR25","volume-title":"Assessment report on Salvia Officinalis L., Folium and Salvia Officinalis L., Aetheroleum","author":"European Medicines Agency","year":"2010","unstructured":"European Medicines Agency: Assessment report on Salvia Officinalis L., Folium and Salvia Officinalis L., Aetheroleum. 2010, [http:\/\/www.emea.europa.eu\/docs\/en_GB\/document_library\/Herbal_-_HMPC_assessment_report\/2010\/02\/WC500070850.pdf]"},{"key":"377_CR26","first-page":"4349","volume":"5","author":"GG Franchi","year":"2011","unstructured":"Franchi GG, Nencini C, Collavoli E, Massarelli P: Composition and antioxidant activity in vitro of different St. John's Wort (Hypericum perforatum L.) extracts. Journal of Medicinal Plants Research. 2011, 5: 4349-4353.","journal-title":"Journal of Medicinal Plants Research"},{"key":"377_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1752-153X-5-34","volume":"5","author":"DZ Or\u010di\u0107","year":"2011","unstructured":"Or\u010di\u0107 DZ, Mimica-Duki\u0107 NM, Franci\u0161kovi\u0107 MM, Petrovi\u0107 SS, Jovin E\u0110: Antioxidant activity relationship of phenolic compounds in Hypericum perforatum L. Chem Centr J. 2011, 5: 34-10.1186\/1752-153X-5-34.","journal-title":"Chem Centr J"},{"key":"377_CR28","first-page":"113","volume":"XLII","author":"S Valimareanu","year":"2008","unstructured":"Valimareanu S, Deliu C: Polymorphism detection of in vitro cultivated Epilobium (Onagraceae) species using RAPD method. Contribu\u0163ii Botanice. 2008, XLII: 113-120.","journal-title":"Contribu\u0163ii Botanice"},{"key":"377_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1055\/s-2000-8616","volume":"66","author":"C Kohlert","year":"2000","unstructured":"Kohlert C, Van Rensen I, Marz R, Schindler G, Graefe EU, Veit M: Bioavailability and pharmokinetics of natural volatile terpenes in animal and humans. Planta Medica. 2000, 66: 495-505. 10.1055\/s-2000-8616.","journal-title":"Planta Medica"},{"key":"377_CR30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1590\/S1516-635X2008000200006","volume":"10","author":"MSR Barreto","year":"2008","unstructured":"Barreto MSR, Menten JFM, Racanicci AMC, Pereira PWZ, Rizzo PV: Plant extracts used as growth promoters in broilers. Brazilian Journal of Poultry Science. 2008, 10: 109-115.","journal-title":"Brazilian Journal of Poultry Science"},{"key":"377_CR31","first-page":"275","volume":"11","author":"CMA Iwegbue","year":"2008","unstructured":"Iwegbue CMA, Nwajei GE, Iyoha EH: Heavy metal residues of chicken meat and gizzard and turkey meat consumed in Southern Nigeria. Bulgarian Journal of Veterinary Medicine. 2008, 11: 275-280.","journal-title":"Bulgarian Journal of Veterinary Medicine"},{"key":"377_CR32","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jhazmat.2008.07.050","volume":"163","author":"OD Uluozlu","year":"2009","unstructured":"Uluozlu OD, Tuzen M, Mendil D, Soylak M: Assessment of trace element contents of chicken products from Turkey. Journal of Hazardous Materials. 2009, 163: 982-987. 10.1016\/j.jhazmat.2008.07.050.","journal-title":"Journal of Hazardous Materials"},{"key":"377_CR33","first-page":"743","volume":"2","author":"JC Akan","year":"2010","unstructured":"Akan JC, Abdulrahman FI, Sodipo OA, Chiroma YA: Distribution of heavy metals in the liver, kidney and meat of beef, mutton, caprine and chicken from Kasuwan Shanu market in Maiduguri Metropolis, Borno State, Nigeria. Research Journal of Applied Sciences, Engineering and Technology. 2010, 2: 743-748.","journal-title":"Research Journal of Applied Sciences, Engineering and Technology"},{"key":"377_CR34","unstructured":"Ordinance 975\/16 XII 1998 of Romanian Ministry of Health. [http:\/\/www.unilab.ro\/downloads\/O%20975%20norme%20igienico-sanitare%20-%20marieta.pdf]"},{"issue":"1","key":"377_CR35","first-page":"63","volume":"V","author":"M Harmanescu","year":"2007","unstructured":"Harmanescu M: Heavy Metals Determination in Selected Medicinal Plants. Annals of the Faculty of Engineering Hunedoara - Journal of Engineering. 2007, V (1): 63-68.","journal-title":"Annals of the Faculty of Engineering Hunedoara - Journal of Engineering"},{"key":"377_CR36","volume-title":"Nutrient Requirements of Poultry","author":"Subcommittee on Poultry Nutrition, National Research Council","year":"1994","unstructured":"Subcommittee on Poultry Nutrition, National Research Council: Nutrient Requirements of Poultry. 1994, The National Academies Home, 500 Fifth St. N.W. Washington, D.C, 20001 http:\/\/www.nap.edu\/catalog.php?record_id=2114, Ninth Revised","edition":"Ninth Revised"},{"key":"377_CR37","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.foodchem.2010.12.026","volume":"126","author":"I Ignat","year":"2011","unstructured":"Ignat I, Volf I, Popa VI: A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables. Food Chem. 2011, 126: 1821-1835. 10.1016\/j.foodchem.2010.12.026.","journal-title":"Food Chem"},{"key":"377_CR38","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0021-9258(18)84277-6","volume":"27","author":"O Folin","year":"1927","unstructured":"Folin O, Ciocalteu V: On tyrosine and tryptophane determination in proteins. Journal of Biological Chemistry. 1927, 27: 627-650.","journal-title":"Journal of Biological Chemistry"},{"key":"377_CR39","first-page":"123","volume":"65","author":"M Harmanescu","year":"2008","unstructured":"Harmanescu M, Moisuc A, Radu F, Dragan SI, Gergen I: Total polyphenol content determination in complex matrix of medicinal plants from Romania by NIR spectroscopy. Bulletin UASVM Agriculture. 2008, 65: 123-128.","journal-title":"Bulletin UASVM Agriculture"},{"key":"377_CR40","first-page":"486","volume":"XL","author":"D Moigradean","year":"2007","unstructured":"Moigradean D, Poiana MA, Gogoasa I, Harmanescu M, Gergen I, Lazureanu A: The correlations between total antioxidant capacity and total polyphenol content established for tomatoes. Lucr\u0103ri stiin\u0142ifice medicin\u0103 veterinar\u0103. 2007, XL: 486-489.","journal-title":"Lucr\u0103ri stiin\u0142ifice medicin\u0103 veterinar\u0103"}],"container-title":["Chemistry Central Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-153X-6-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1752-153X-6-19\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-153X-6-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T19:01:31Z","timestamp":1630522891000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcchem.biomedcentral.com\/articles\/10.1186\/1752-153X-6-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,19]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["377"],"URL":"https:\/\/doi.org\/10.1186\/1752-153x-6-19","relation":{},"ISSN":["1752-153X"],"issn-type":[{"value":"1752-153X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,19]]},"assertion":[{"value":"22 January 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"19"}}