{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:15Z","timestamp":1787068395921,"version":"build-2736575974"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chemistry Central Journal"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The emergence of multi-drug resistant tuberculosis (MDR-TB) has heightened the need for new chemical classes and innovative strategies to tackle TB infections. It is urgent to discover new classes of molecules without cross-resistance with currently used antimycobacterial drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen new 8-substituted protoberberine derivatives were synthesized and evaluated for their anti-mycobacterial activities against\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      (\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      ) strain H\n                      <jats:sub>37<\/jats:sub>\n                      Rv. Among them, compound\n                      <jats:bold>7g<\/jats:bold>\n                      was the most effective antitubercular agent with minimum inhibitory concentration (MIC) of 0.5 \u03bcg\/mL. Moreover, it also afforded a potent antitubercular effect against clinically isolated MDR strains of\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      with MICs ranging from 0.25 to 1.0 \u03bcg\/mL, suggesting a novel mode of action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The structure\u2212activity relationship (SAR) analysis revealed that introduction of a substituent at the 8-position in pseudoprotoberberine, especially an\n                      <jats:italic>n<\/jats:italic>\n                      -decyl, could significantly enhance the anti-TB activity. We consider 8-\n                      <jats:italic>n<\/jats:italic>\n                      -decylberberines to be a novel family of anti-tubercular agents with an advantage of inhibiting MDR strains of\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1752-153x-7-117","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T04:14:21Z","timestamp":1373429661000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis and structure\u2212activity relationship of 8-substituted protoberberine derivatives as a novel class of antitubercular agents"],"prefix":"10.1186","volume":"7","author":[{"given":"Ying-Hong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Gen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Wen","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Qing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,10]]},"reference":[{"key":"645_CR1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/35021291","volume":"406","author":"D Butler","year":"2000","unstructured":"Butler D: New fronts in an old war. 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