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The intention of this study was to investigate the chemical composition and the activity against<jats:italic>Candida albicans<\/jats:italic>of volatile oils obtained from<jats:italic>Artemisia dracunculus<\/jats:italic>,<jats:italic>A. abrotanum<\/jats:italic>,<jats:italic>A. absinthium<\/jats:italic>and<jats:italic>A. vulgaris<\/jats:italic>(<jats:italic>Asteraceae<\/jats:italic>). The aim of the study was to identify new chemical compounds that have effect against<jats:italic>C. albicans<\/jats:italic>.<\/jats:p><jats:p>The essential oils were obtained by hydrodistillation or extraction with dichloromethane (a new procedure we developed trying to obtain better, more separated compounds) from air dried above ground plant material and analyzed by GC-MS. Additionally commercial essential oils from the same species were tested. The<jats:italic>Candida albicans<\/jats:italic>inhibition studies were carried out by the paper disc diffusion method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The essential oils shared common components but presented differences in composition and showed variable antifungal activity. Davanone and derivatives thereof, compounds with silphiperfolane skeleton, estragole, davanone oil, \u03b2-thujone, sabinyl acetate, herniarin, cis-chrysanthenyl acetate, 1,8-cineol, and terpineol were the main components of<jats:italic>Artemisia<\/jats:italic>volatiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among the volatile fractions tested those from<jats:italic>A. abrotanum<\/jats:italic>containing davanone or silphiperfolane derivatives showed the highest antifungal activity. The<jats:italic>in vitro<\/jats:italic>tests revealed that the<jats:italic>Artemisia<\/jats:italic>oils are promising candidates for further research to develop novel anti-candida drugs.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-153x-8-6","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T18:21:03Z","timestamp":1391019663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris"],"prefix":"10.1186","volume":"8","author":[{"given":"Diana","family":"Obistioiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo T","family":"Cristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Schmerold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remigius","family":"Chizzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Stolze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Nichita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorica","family":"Chiurciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"720_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.17348\/era.7.0.147-162","volume":"7","author":"MQ Hayat","year":"2009","unstructured":"Hayat MQ, Ashraf M, Khan MA, Jabeen S: Ethnobotany of the genus Artemisia L. 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