{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:41:24Z","timestamp":1772422884712,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry Central Journal"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1752-153x-8-9","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T16:02:16Z","timestamp":1391270536000},"source":"Crossref","is-referenced-by-count":23,"title":["Tandem Aldol-Michael reactions in aqueous diethylamine medium: a greener and efficient approach to dimedone-barbituric acid derivatives"],"prefix":"10.1186","volume":"8","author":[{"given":"Assem","family":"Barakat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Mohammed","family":"Al-Majid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz Moshabab","family":"Al-Ghamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahia Nasser","family":"Mabkhot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Rafiq Hussain Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem A","family":"Ghabbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoong-Kun","family":"Fun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"721_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-94-011-4950-1","volume-title":"Organic Synthesis in Water","author":"PA Grieco","year":"1998","unstructured":"Grieco PA: Organic Synthesis in Water. 1998, London: Thomson Science, 1-278."},{"key":"721_CR2","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1021\/cr030009u","volume":"105","author":"CJ Li","year":"2005","unstructured":"Li CJ: Organic reactions in aqueous media with a focus on carbon-carbon bond formations: a decade update. Chem Rev. 2005, 105: 3095-3165. 10.1021\/cr030009u.","journal-title":"Chem Rev"},{"key":"721_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0065-2725(08)60921-6","volume":"38","author":"JT Bojarski","year":"1985","unstructured":"Bojarski JT, Mokrocz JL, Barton HJ, Paluchowska MH: Recent progress in barbituric acid chemistry. Adv Heterocycl Chem. 1985, 38: 229-297.","journal-title":"Adv Heterocycl Chem"},{"key":"721_CR4","volume-title":"(Hrsg.): Comprehensive Heterocyclic Chemistry, Volume 6","author":"K Undheim","year":"1996","unstructured":"Undheim K, Bennecke T, Katritzky AR, Rees CW, Scriven EFV, Boulton AJ: (Hrsg.): Comprehensive Heterocyclic Chemistry, Volume 6. 1996, Oxford: Elsevier Pergamon, Suppl. 93"},{"key":"721_CR5","first-page":"379","volume":"16","author":"S Angerer","year":"2004","unstructured":"Angerer S: Product class 12: pyrimidines. Sci Synth. 2004, 16: 379-572.","journal-title":"Sci Synth"},{"key":"721_CR6","first-page":"827","volume":"43","author":"SRG Sans","year":"1988","unstructured":"Sans SRG, Chosaz MG: Historical aspects and applications of barbituric acid derivatives. Pharmazie. 1988, 43: 827-829.","journal-title":"Pharmazie"},{"key":"721_CR7","volume-title":"Modern Medical Chemistry","author":"JB Taylor","year":"1994","unstructured":"Taylor JB: Modern Medical Chemistry. 1994, New York: Prentice Hall"},{"key":"721_CR8","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/S0960-894X(99)00238-3","volume":"9","author":"DJ Guerin","year":"1999","unstructured":"Guerin DJ, Mazeas D, Musale MS, Naguib FNM, Safarjalani ONA, Kouni MH, Panzica RP: Uridine phosphorylase inhibitors: chemical modification of benzyloxybenzyl barbituric acid and its effects on UrdPase inhibition. Bioorg Med Chem Lett. 1999, 9: 1477-1480. 10.1016\/S0960-894X(99)00238-3.","journal-title":"Bioorg Med Chem Lett"},{"key":"721_CR9","first-page":"243","volume-title":"Medical pharmacology","author":"G Andrews","year":"1976","unstructured":"Andrews G: Medical pharmacology. 1976, Saint Louis, MO: The CV Mosby Co, 243-250."},{"key":"721_CR10","first-page":"143","volume-title":"Principles of medicinal chemistry","author":"WO Foye","year":"1989","unstructured":"Foye WO: Principles of medicinal chemistry. 1989, Pennsylvania, PA: Lea & Febiger, 143-237."},{"key":"721_CR11","first-page":"358","volume-title":"The pharmacological basis of therapeutics","author":"LS Goodman","year":"1991","unstructured":"Goodman LS, Gilman A: The pharmacological basis of therapeutics. 1991, New Delhi: Mc Graw-Hill, 358-360."},{"key":"721_CR12","first-page":"1519","volume":"17","author":"S Senda","year":"1967","unstructured":"Senda S, Izumi H, Fujimura H: Uracil derivatives and related compounds. VI. Derivatives of 5-alkyl-2,4,6-trioxoperhydropyrimidine as anti-inflammatory agents. Arznein Forsch. 1967, 17: 1519-1523.","journal-title":"Arznein Forsch"},{"key":"721_CR13","first-page":"97","volume":"44","author":"E Fisher","year":"1903","unstructured":"Fisher E, Moring JR: Ueber eine neue klasse von schlafmitteln. Ther Ggw. 1903, 44: 97-105.","journal-title":"Ther Ggw"},{"key":"721_CR14","first-page":"164","volume":"4","author":"WJ Doran","year":"1959","unstructured":"Doran WJ: Barbituric acid hypnotics. Med Chem. 1959, 4: 164-167.","journal-title":"Med Chem"},{"key":"721_CR15","first-page":"231","volume":"31","author":"B Bobranski","year":"1977","unstructured":"Bobranski B: Progress in chemistry of barbituric acid. Wiad Chem. 1977, 31: 231-278.","journal-title":"Wiad Chem"},{"key":"721_CR16","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1021\/jo00869a003","volume":"41","author":"GL Anderson","year":"1976","unstructured":"Anderson GL, Shim JL, Brown AD: Pyrido[2,3-d]pyrimidines. IV. Synthetic studies leading to various oxopyrido[2,3-d]pyrimidines. J Org Chem. 1976, 41: 1095-1099. 10.1021\/jo00869a003.","journal-title":"J Org Chem"},{"key":"721_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1021\/jm00177a025","volume":"23","author":"EM Grivaky","year":"1980","unstructured":"Grivaky EM, Lee S, Siyal CW, Duch DS, Nichol CA: Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine. J Med Chem. 1980, 23: 327-329. 10.1021\/jm00177a025.","journal-title":"J Med Chem"},{"key":"721_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2725(09)09801-8","volume":"98","author":"SH El Ashry El","year":"2009","unstructured":"El Ashry El SH, Awada LF, El Kilany Y, El Ibrahim S: Chapter 1 dimedone: a versatile precursor for annulated heterocycles. Adv Heterocycl Chem. 2009, 98: 1-141.","journal-title":"Adv Heterocycl Chem"},{"key":"721_CR19","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.2116\/analsci.18.1267","volume":"18","author":"T Saitoh","year":"2002","unstructured":"Saitoh T, Taguchi K, Hiraide M: Derivatization of formaldehyde with dimedone and subsequent sorption on sodium dodecylsulfate\/alumina admicelles for fluorometric analysi. Anal Sci. 2002, 18: 1267-1268. 10.2116\/analsci.18.1267.","journal-title":"Anal Sci"},{"key":"721_CR20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/10426509308034375","volume":"81","author":"RJ Cremlyn","year":"1993","unstructured":"Cremlyn RJ, Saunders D: Chlorosulfonation of 9-aryl 3,36,6-tetramethyloctahydroxanthen-1,8-diones. Phosphorus Sulfur Silicon. 1993, 81: 73-82. 10.1080\/10426509308034375.","journal-title":"Phosphorus Sulfur Silicon"},{"key":"721_CR21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0039-9140(90)80237-A","volume":"37","author":"ME Bodini","year":"1990","unstructured":"Bodini ME, Pardo J, Arancibia V: Spectrophotometric determination of selenium(IV) with 5,5-dimethyl-1,3-cyclohexanedione. Talanta. 1990, 37: 439-442. 10.1016\/0039-9140(90)80237-A.","journal-title":"Talanta"},{"key":"721_CR22","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1002\/ejoc.200700586","volume":"2007","author":"M Gruttadauria","year":"2007","unstructured":"Gruttadauria M, Giacalone F, Marculesco AM, Meo PL, Riela S, Noto R: Hydrophobically directed aldol reactions: polystyrene-supported L-proline asa recyclable catalyst for direct asymmetric Aldol reactions in the presence of water. Eur J Org Chem. 2007, 2007: 4688-10.1002\/ejoc.200700586.","journal-title":"Eur J Org Chem"},{"key":"721_CR23","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1021\/ar040001m","volume":"37","author":"R Breslow","year":"2004","unstructured":"Breslow R: Determining the geometries of transition states by use of antihydrophobic additives in water. Acc Chem Res. 2004, 37: 471-478. 10.1021\/ar040001m.","journal-title":"Acc Chem Res"},{"key":"721_CR24","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.1002\/anie.200604952","volume":"46","author":"DG Blackmond","year":"2007","unstructured":"Blackmond DG, Armstrong A, Coombe V, Wells A: Water in organocatalytic processes: Debunking the Myths. Angew Chem Int Ed Engl. 2007, 46: 3798-3800. 10.1002\/anie.200604952.","journal-title":"Angew Chem Int Ed Engl"},{"key":"721_CR25","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1016\/j.tetlet.2012.06.040","volume":"53","author":"MS Abaee","year":"2012","unstructured":"Abaee MS, Cheraghi S, Navidipoor S, Mojtahedi MM, Forghani S: An efficient tandem aldol condensation-thia-Michael addition process. Tetrahedron Lett. 2012, 53: 4405-4408. 10.1016\/j.tetlet.2012.06.040.","journal-title":"Tetrahedron Lett"},{"key":"721_CR26","doi-asserted-by":"publisher","first-page":"5185","DOI":"10.1016\/j.tet.2013.04.063","volume":"69","author":"A Barakat","year":"2013","unstructured":"Barakat A, Al-Majid AA: Shahidul Islam M, Al-Othman ZA: Highly enantioselective Friedel\u2009\u2212\u2009Crafts alkylations of indoles with \u03b1, \u03b2-unsaturated ketones under Cu(II)-simple oxazoline-imidazoline catalysts. Tetrahedron. 2013, 69: 5185-5192. 10.1016\/j.tet.2013.04.063.","journal-title":"Tetrahedron"},{"key":"721_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/jhet.5570400124","volume":"40","author":"BS Jursic","year":"2003","unstructured":"Jursic BS: Preparation of unsubstituted dipyridine-dibarbituric acid ylide through Dimerization of pyridin-2-ylmethylenepyrimidinetrione as a reactive intermediate. J Heterocyclic Chem. 2003, 40: 167-170. 10.1002\/jhet.5570400124.","journal-title":"J Heterocyclic Chem"},{"key":"721_CR28","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/jhet.5570400310","volume":"40","author":"BS Jursic","year":"2003","unstructured":"Jursic BS, Neumann DM: Preparation of 5,5'-pyrilidene and 5,5'-quinolidene bis-barbituric acid derivatives. J Heterocyclic Chem. 2003, 40: 465-474. 10.1002\/jhet.5570400310.","journal-title":"J Heterocyclic Chem"},{"key":"721_CR29","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1039\/c3ra46551a","volume":"4","author":"A Barakat","year":"2014","unstructured":"Barakat A, Al-Majid AM, Al-Najjar HJ, Mabkhot YN, Ghabbour HA, Fun H-K: An efficient and green procedure for synthesis of rhodanine derivatives by Aldol-thia-Michael protocol using aqueous diethylamine. RSC Adv. 2014, 4: 4909-4916. 10.1039\/c3ra46551a.","journal-title":"RSC Adv"},{"key":"721_CR30","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.3390\/molecules19011150","volume":"19","author":"HJ Al-Najjar","year":"2014","unstructured":"Al-Najjar HJ, Barakat A, Al-Majid AM, Mabkhot YN, Weber M, Ghabbour HA, Fun H-K: A greener and efficient approach to Michael addition of barbituric acid to nitroalkene in aqueous diethylamine medium. Molecules. 2014, 19: 1150-1162. 10.3390\/molecules19011150.","journal-title":"Molecules"},{"key":"721_CR31","doi-asserted-by":"publisher","first-page":"23762","DOI":"10.3390\/ijms141223762","volume":"14","author":"AM Al-Majid","year":"2013","unstructured":"Al-Majid AM, Barakat A, Al-Najjar HJ, Mabkhot YN, Ghabbour HA, Fun H-K: Tandem Aldol-Michael reactions in aqueous diethylamine medium: a greener and efficient approach to bis-pyrimidine derivatives. Int J Mol Sci. 2013, 14: 23762-23773. 10.3390\/ijms141223762.","journal-title":"Int J Mol Sci"}],"container-title":["Chemistry Central Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-153X-8-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T15:58:06Z","timestamp":1576684686000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcchem.biomedcentral.com\/articles\/10.1186\/1752-153X-8-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["721"],"URL":"https:\/\/doi.org\/10.1186\/1752-153x-8-9","relation":{},"ISSN":["1752-153X"],"issn-type":[{"value":"1752-153X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]},"article-number":"9"}}