{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:02:54Z","timestamp":1790827374656,"version":"4.1.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T00:00:00Z","timestamp":1196121600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Vitamin C is a precursor of oxalate and promoter of its absorption, potentially causing hyperoxaluria. Malabsorption causes Calcium (Ca) chelation with fatty acids, producing enteric hyperoxaluria.<\/jats:p>\n          <jats:p>\n            <jats:bold>Case<\/jats:bold>\n          <\/jats:p>\n          <jats:p>A 73-year-old man with both risk factors was hospitalized with serum creatinine of 8.4 mg\/dL (versus 1.2 mg\/dL four months earlier) (normal 0.6\u20131.3 mg\/dL). Given his oxalate-rich diet, chronic diarrhea, and daily 680 mg vitamin C and furosemide, we postulated Ca oxalate-induced nephropathy, a diagnosis confirmed by documenting hyperoxaluria, and finding of diffuse intraluminal crystals and extensive interstitial fibrosis on biopsy. He was hemodialysed 6 times to remove excess oxalate. Two weeks off vitamin C, his creatinine spontaneously fell to 3.1 mg\/dL. Three months later, on low oxalate diet and 100 mg vitamin B6, urine oxalate to creatinine ratio decreased from 0.084 to 0.02 (normal &lt; 0.035), while creatinine fell and stayed at 1.8 mg\/dL.<\/jats:p>\n          <jats:p>\n            <jats:bold>Conclusion<\/jats:bold>\n          <\/jats:p>\n          <jats:p>1) High-dose vitamin C can induce hyperoxaluric nephropathy and progressive renal failure, especially if aggravated by diarrhea, oxalate-rich diet, metabolic acidosis, and dehydration. 2) The diagnosis should be suspected in unexplained renal insufficiency when associated with these risk factors. 3) Since prompt treatment could avert end-stage renal disease, we recommend monitoring urinary oxalate in patients on high-dose vitamin C and renal biopsy if necessary.<\/jats:p>","DOI":"10.1186\/1752-1947-1-155","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T19:13:57Z","timestamp":1196190837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Vitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure: a case report"],"prefix":"10.1186","volume":"1","author":[{"given":"Shradha","family":"Rathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,11,27]]},"reference":[{"issue":"6","key":"155_CR1","first-page":"729","volume":"124","author":"HJ Canos","year":"1981","unstructured":"Canos HJ, Hogg GA, Jeffery JR: Oxalate nephropathy due to gastrointestinal disorders. 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J Nutr. 2005, 135 (7): 1673-1677.","journal-title":"J Nutr"},{"issue":"6","key":"155_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1053\/j.ajkd.2004.08.028","volume":"44","author":"W Chai","year":"2004","unstructured":"Chai W, Liebman M, Kynast-Gales S, Massey L: Oxalate absorption and endogenous oxalate synthesis from ascorbate in calcium oxalate stone formers and non-stone formers. Am J Kidney Dis. 2004, 44 (6): 1060-1069. 10.1053\/j.ajkd.2004.08.028.","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"155_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1378\/chest.118.2.561","volume":"118","author":"S Mashour","year":"2000","unstructured":"Mashour S, Turner JF, Merrell R: Acute renal failure, oxalosis, and vitamin C supplementation: a case report and review of the literature. 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