{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:04:00Z","timestamp":1768457040395,"version":"3.49.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T00:00:00Z","timestamp":1213315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>\n              <jats:italic>Francisella tularensis<\/jats:italic>, a facultative intracellular Gram-negative bacterium, has rarely been reported as an agent of pericarditis, generally described as a complication of tularemia sepsis. <jats:italic>F. tularensis<\/jats:italic> is a fastidious organism that grows poorly on standard culture media and diagnosis is usually based on serological tests. However, cross-reactions may occur. Western blotting allows the correct diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A non-smoking 53-year-old woman was admitted to hospital with a large posterior pericardial effusion. Serological tests showed a seroconversion in antibody titers to <jats:italic>F. tularensis<\/jats:italic> (IgG titer = 400) and <jats:italic>Legionella pneumophila<\/jats:italic> (IgG titer = 512). <jats:italic>F. tularensis<\/jats:italic> was identified by Western immunoblotting following cross-adsorption. The patient reported close contact with rabbits 2 weeks prior to the beginning of symptoms of pericarditis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We report a rare case of pericardial effusion as the only manifestation of infection by <jats:italic>F. tularensis<\/jats:italic>. The etiological diagnosis is based on serology. Western blotting and cross-adsorption allow differential diagnosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-2-206","type":"journal-article","created":{"date-parts":[[2008,6,27]],"date-time":"2008-06-27T18:12:19Z","timestamp":1214590339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pericardial effusion as the only manifestation of infection with Francisella tularensis: a case report"],"prefix":"10.1186","volume":"2","author":[{"given":"C\u00e9cile","family":"Landais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,6,13]]},"reference":[{"key":"393_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1128\/CMR.15.4.631-646.2002","volume":"15","author":"J Ellis","year":"2002","unstructured":"Ellis J, Oyston PC, Green M, Titball RW: Tularemia. Clin Microbiol Rev. 2002, 15: 631-646. 10.1128\/CMR.15.4.631-646.2002.","journal-title":"Clin Microbiol Rev"},{"key":"393_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/00005792-198507000-00006","volume":"64","author":"ME Evans","year":"1985","unstructured":"Evans ME, Gregory DW, Schaffner W, McGee ZA: Tularemia: a 30-year experience with 88 cases. Medicine (Baltimore). 1985, 64: 251-269.","journal-title":"Medicine (Baltimore)"},{"key":"393_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/01.md.0000101574.54295.73","volume":"82","author":"PY Levy","year":"2003","unstructured":"Levy PY, Corey R, Berger P, Habib G, Bonnet JL, Levy S, Messana T, Djiane P, Frances Y, Botta C, DeMicco P, Dumon H, Mundler O, Chomel JJ, Raoult D: Etiologic diagnosis of 204 pericardial effusions. 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