{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:52:18Z","timestamp":1773982338013,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T00:00:00Z","timestamp":1218153600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Hypercalcemia is well described in various granulomatous disorders, such as sarcoidosis, tuberculosis, berylliosis, leprosy and fungal infections. However, the association of <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> and hypercalcemia is rare: to the best of our knowledge, only two cases have previously been reported, and neither had a clear documentation of the etiology of the hypercalcemia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We report the case of a 22-year-old man in whom disseminated infection with paracoccidioidomycosis was associated with hypercalcemia. The patient had a high normal serum level of 1,25-dihydroxyvitamin D and a suppressed parathyroid hormone value, an indication that the hypercalcemia was not mediated by parathyroid hormone and might be associated with 1,25-dihydroxyvitamin D.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The episode resolved readily with administration of corticosteroids, an outcome suggesting that this is an effective treatment of hypercalcemia of this origin. On follow-up, while receiving antifungal therapy for <jats:italic>P. brasiliensis<\/jats:italic> the patient's calcium values remained normal.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-2-262","type":"journal-article","created":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T18:13:56Z","timestamp":1218219236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report"],"prefix":"10.1186","volume":"2","author":[{"given":"Rafael Moura","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loureno","family":"Cezana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Miti Lemos","family":"Tsukumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Ant\u00f4nio","family":"de Carvalho-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Jos\u00e9 Abdalla","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,8]]},"reference":[{"issue":"6","key":"449_CR1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/00000441-199912000-00010","volume":"318","author":"MY Ali","year":"1999","unstructured":"Ali MY, Gopal KV, Llerena LA, Taylor HC: Hypercalcemia associated with infection by Cryptococcus neoformans and Coccidioides immitis. 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