{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:07:09Z","timestamp":1764259629805},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:00:00Z","timestamp":1222732800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Juvenile polyposis syndrome(JPS) is a rare autosomal dominant inherited condition. Hamartomatous polyps can affect the entire gastrointestinal tract but usually predominate in the colon. In this case report we present an unusual case of JPS that presented with massive gastric polyposis requiring a total gastrectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 51-year-old man presented with symptoms of gastric outlet obstruction and upper gastrointestinal bleeding. Gastroscopy showed massive gastric polyposis with a large antral polyp that had prolapsed through the pylorus causing gastric outlet obstruction. Initially endoscopic polypectomy was performed, but due to progressive symptoms a total gastrectomy was then performed. Histology confirmed massive gastric juvenile polyposis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Massive gastric polyposis is an uncommon manifestation of juvenile polyposis syndrome. This case illustrates important principles in managing this condition.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-2-314","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T18:14:42Z","timestamp":1222798482000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Juvenile polyposis syndrome affecting the stomach: A case report"],"prefix":"10.1186","volume":"2","author":[{"given":"Steven","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Dwerryhouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Safranek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hardwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,9,30]]},"reference":[{"key":"501_CR1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/j.1365-2559.1988.tb02093.x","volume":"13","author":"JR Jass","year":"1988","unstructured":"Jass JR, Williams CB, Bussey HJ, Morson BC: Juvenile polyposis \u2013 a precancerous condition. Histopathology. 1988, 13: 619-30.","journal-title":"Histopathology"},{"key":"501_CR2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1136\/jmg.2004.018598","volume":"41","author":"JR Howe","year":"2004","unstructured":"Howe JR, Sayed MG: The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet. 2004, 41: 484-91. 10.1136\/jmg.2004.018598.","journal-title":"J Med Genet"},{"key":"501_CR3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00439-002-0748-9","volume":"111","author":"W Friedl","year":"2002","unstructured":"Friedl W, Uhlhaas S: Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers. Human genetics. 2002, 111: 108-111. 10.1007\/s00439-002-0748-9.","journal-title":"Human genetics"},{"key":"501_CR4","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1126\/science.280.5366.1086","volume":"280","author":"JR Howe","year":"1998","unstructured":"Howe JR, Roth S, Ringold JC, Summers RW, Jarvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM, Aaltonen LA: Mutations in the SMAD4\/DPC4 gene in juvenile polyposis. Science. 1998, 280: 1086-8. 10.1126\/science.280.5366.1086.","journal-title":"Science"},{"key":"501_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/BF02303487","volume":"5","author":"JR Howe","year":"1998","unstructured":"Howe JR, Mitros FA, Summers RW: The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann Surg Oncol. 1998, 5: 751-6. 10.1007\/BF02303487.","journal-title":"Ann Surg Oncol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-2-314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-1947-2-314\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-2-314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-2-314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T03:34:57Z","timestamp":1630467297000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/1752-1947-2-314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,30]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["501"],"URL":"https:\/\/doi.org\/10.1186\/1752-1947-2-314","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,30]]},"assertion":[{"value":"13 October 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"314"}}