{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:27:23Z","timestamp":1649204843184},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Syphilis is well known as an infectious disease which can present with a large variety of symptoms. Clinical diagnosis can be difficult and may be complicated in modern medicine by immunosuppressive treatment and possible side effects of medication.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We describe a rare case of placoid chorioretinitis due to <jats:italic>Treponema pallidum<\/jats:italic> which developed after the primary symptom of proteinuria was not recognized as a rare manifestation of syphilis. Diagnosis of syphilitic chorioretinitis and\/or endophthalmitis was made by broad range amplification of the bacterial 16S ribosomal RNA gene obtained from vitreous after diagnostic vitrectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case shows that clinicians should be alert in patients with proteinuria and chorioretinitis as they can represent rare manifestations of syphilis. Syphilis should be in the differential diagnosis of any unknown symptom and in the presumed side effects of medication.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-2-33","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T19:13:37Z","timestamp":1201893217000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report"],"prefix":"10.1186","volume":"2","author":[{"given":"Claudia","family":"Handtrack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Knorr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin U","family":"Amann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schoerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl F","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Gei\u00dfd\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"220_CR1","first-page":"2768","volume-title":"Principles and practice of infectious diseases","author":"EC Tramont","year":"2005","unstructured":"Tramont EC: Treponema pallidum (Syphilis). Principles and practice of infectious diseases. Edited by: Mandell GL, Bennet JE, Dolin R. 2005, Philadelphia , Elsevier, 2768-2785. sixth","edition":"sixth"},{"issue":"1","key":"220_CR2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/QCO.0b013e32801158cc","volume":"20","author":"TA Peterman","year":"2007","unstructured":"Peterman TA, Furness BW: The resurgence of syphilis among men who have sex with men. Curr Opin Dis. 2007, 20 (1): 54-59.","journal-title":"Curr Opin Dis"},{"issue":"5","key":"220_CR3","first-page":"341","volume":"324","author":"DJ Kusner","year":"1991","unstructured":"Kusner DJ, Ellner JJ: Syphilis--a reversible cause of nephrotic syndrome in HIV infection. N Engl J Med. 1991, 324 (5): 341-342.","journal-title":"N Engl J Med"},{"issue":"3","key":"220_CR4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/oxfordjournals.ndt.a091852","volume":"4","author":"R Cahen","year":"1989","unstructured":"Cahen R, Francois B, Trolliet P, Gilly J, Parchoux B: Aetiology of membranous glomerulonephritis: a prospective study of 82 adult patients. Nephrol Dial Transplant. 1989, 4 (3): 172-180.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"220_CR5","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/S0272-6386(87)80096-3","volume":"9","author":"NK Krane","year":"1987","unstructured":"Krane NK, Espenan P, Walker PD, Bergman SM, Wallin JD: Renal disease and syphilis: a report of nephrotic syndrome with minimal change disease. Am J Kidney Dis. 1987, 9 (2): 176-179.","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"220_CR6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1056\/NEJM199207303270501","volume":"327","author":"DA Relman","year":"1992","unstructured":"Relman DA, Schmidt TM, MacDermott RP, Falkow S: Identification of the uncultured bacillus of Whipple's disease. N Engl J Med. 1992, 327 (5): 293-301.","journal-title":"N Engl J Med"},{"key":"220_CR7","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1136\/bjo.2006.110288","volume":"91","author":"M M\u00fcller","year":"2006","unstructured":"M\u00fcller M, Ewert I, Hansmann F, Tiemann C, Hagedorn HJ, Solbach W, Roider J, N\u00f6lle B, Laqua H, Hoerauf H: Detection of Treponema pallidum in the Vitreous by PCR. Br J Ophthalmol. 2006, 91: 592-595. 10.1136\/bjo.2006.110288.","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"220_CR8","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1136\/bjo.2005.083196","volume":"90","author":"MS Rajan","year":"2006","unstructured":"Rajan MS, Pantelidis P, Tong CY, French GL, Graham EM, Stanford MR: Diagnosis of Treponema pallidum in vitreous samples using real time polymerase chain reaction. Br J Ophthalmol. 2006, 90 (5): 647-648. 10.1136\/bjo.2005.083196.","journal-title":"Br J Ophthalmol"},{"issue":"23","key":"220_CR9","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1056\/NEJMoa012684","volume":"346","author":"IC Michelow","year":"2002","unstructured":"Michelow IC, Wendel GD, Norgard MV, Zeray F, Leos NK, Alsaadi R, Sanchez PJ: Central nervous system infection in congenital syphilis. N Engl J Med. 2002, 346 (23): 1792-1798. 10.1056\/NEJMoa012684.","journal-title":"N Engl J Med"},{"issue":"9","key":"220_CR10","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00417-005-1137-6","volume":"243","author":"TH Tran","year":"2005","unstructured":"Tran TH, Cassoux N, Bodaghi B, Fardeau C, Caumes E, Lehoang P: Syphilitic uveitis in patients infected with human immunodeficiency virus. Graefes Arch Clin Exp Ophthalmol. 2005, 243 (9): 863-869. 10.1007\/s00417-005-1137-6.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"220_CR11","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/S0161-6420(90)32418-1","volume":"97","author":"JD Gass","year":"1990","unstructured":"Gass JD, Braunstein RA, Chenoweth RG: Acute syphilitic posterior placoid chorioretinitis. Ophthalmology. 1990, 97 (10): 1288-1297.","journal-title":"Ophthalmology"},{"issue":"6","key":"220_CR12","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0002-9394(02)02160-8","volume":"135","author":"M Zamani","year":"2003","unstructured":"Zamani M, Garfinkel RA: Corticosteroid-induced modulation of acute syphilitic posterior placoid chorioretinitis. Am J Ophthalmol. 2003, 135 (6): 891-894. 10.1016\/S0002-9394(02)02160-8.","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"220_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1056\/NEJM199707313370504","volume":"337","author":"RT Rolfs","year":"1997","unstructured":"Rolfs RT, Joesoef MR, Hendershot EF, Rompalo AM, Augenbraun MH, Chiu M, Bolan G, Johnson SC, French P, Steen E, Radolf JD, Larsen S: A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med. 1997, 337 (5): 307-314. 10.1056\/NEJM199707313370504.","journal-title":"N Engl J Med"},{"issue":"11","key":"220_CR14","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1001\/jama.290.11.1510","volume":"290","author":"MR Golden","year":"2003","unstructured":"Golden MR, Marra CM, Holmes KK: Update on syphilis: resurgence of an old problem. JAMA. 2003, 290 (11): 1510-1514. 10.1001\/jama.290.11.1510.","journal-title":"JAMA"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-2-33.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-1947-2-33\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-2-33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-2-33.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T11:03:53Z","timestamp":1630494233000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/1752-1947-2-33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["220"],"URL":"https:\/\/doi.org\/10.1186\/1752-1947-2-33","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,1]]},"assertion":[{"value":"13 July 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"33"}}