{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:58:27Z","timestamp":1762541907461},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Traditional management of Gradenigo's syndrome requires aggressive and radical surgery without any attempt to preserve hearing. Recent reports, however, describe a successful outcome after conservative surgical intervention without labyrinthectomy. A similar outcome has also been reported in patients who were only prescribed with antibiotics and did not undergo myringotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We report the case of a 24-year-old Caucasian Greek woman with Gradenigo's syndrome who was treated by draining her petrous apex via an infralabyrithine approach between her posterior semicircular canal and the jugular bulb. Her inner ear was not sacrificed during the procedure. She presented pre-operatively with ipsilateral conductive hearing loss, which recovered completely four weeks after the surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Patients with Gradenigo's syndrome may be successfully treated with a combination of long-term permanent drainage and ventilation of the apical cells with corresponding hearing preservation. This can be achieved via a combination of transmastoid, infralabyrinthine and suprajugular approaches, if such would be allowed by the anatomy of the region or if there is enough space between the posterior semicircular canal and the jugular bulb.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-4-151","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T18:16:44Z","timestamp":1276625804000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic approach to Gradenigo's syndrome: a case report"],"prefix":"10.1186","volume":"4","author":[{"given":"Ilias","family":"Kantas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios G","family":"Balatsouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Aspris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Marangos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"key":"1109_CR1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/S0194-5998(98)70100-7","volume":"119","author":"NA Goldstein","year":"1998","unstructured":"Goldstein NA, Casselbrant ML, Bluestone CD, Kurs-Lasky M: Intratemporal complications of acute otitis media in infants and children. Otolaryngol Head Neck Surg. 1998, 119: 444-454. 10.1016\/S0194-5998(98)70100-7.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1109_CR2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/BF01930369","volume":"774","author":"G Gradenigo","year":"1907","unstructured":"Gradenigo G: \u00dcber die paralyse des nervus abducens bei otitis. Arch Ohrenheileunde. 1907, 774: 149-187. 10.1007\/BF01930369.","journal-title":"Arch Ohrenheileunde"},{"key":"1109_CR3","first-page":"169","volume":"12","author":"DA Gillanders","year":"1983","unstructured":"Gillanders DA: Gradenigo's syndrome revisited. J Otolayngol. 1983, 12: 169-174.","journal-title":"J Otolayngol"},{"key":"1109_CR4","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1258\/0022215011907299","volume":"115","author":"AY Al-Ammar","year":"2001","unstructured":"Al-Ammar AY: Recurrent temporal petrositis. J Laryngol Otol. 2001, 115: 316-318. 10.1258\/0022215011907299.","journal-title":"J Laryngol Otol"},{"key":"1109_CR5","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1177\/000348948309200603","volume":"92","author":"RA Chole","year":"1983","unstructured":"Chole RA, Donald PJ: Petrous apicitis: Clinical considerations. Ann Otol Rhinol Laryngol. 1983, 92: 544-551.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1109_CR6","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/BF01356837","volume":"26","author":"T Murakami","year":"1996","unstructured":"Murakami T, Tsubaki J, Tahara Y, Nagashima T: Gradenigo's syndrome: CT and MRI findings. Pediatr Radiol. 1996, 26: 684-685. 10.1007\/BF01356837.","journal-title":"Pediatr Radiol"},{"key":"1109_CR7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1001\/archotol.1937.00650020048006","volume":"26","author":"MC Myerson","year":"1937","unstructured":"Myerson MC: Suppuration of petrous pyramid. Arch Otolaryngol. 1937, 26: 42-48.","journal-title":"Arch Otolaryngol"},{"key":"1109_CR8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1258\/0022215054020313","volume":"119","author":"B Burston","year":"2005","unstructured":"Burston B, Pretorius PM, Ramsden JD: Gradenigo's syndrome: successful conservative treatment in adult and paediatric patients. J Laryngol Otol. 2005, 119: 325-329. 10.1258\/0022215054020313.","journal-title":"J Laryngol Otol"},{"key":"1109_CR9","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1001\/archotol.1937.00650010166004","volume":"25","author":"J Lempert","year":"1937","unstructured":"Lempert J: Complete apicectomy (mastoidotympanoapicectomy), new technique for complete apical exenteration of apical carotid portion of pertous pyramid. Arch Otolaryngol. 1937, 25: 144-177.","journal-title":"Arch Otolaryngol"},{"key":"1109_CR10","first-page":"396","volume":"40","author":"SJ Kepetzky","year":"1931","unstructured":"Kepetzky SJ, Almour R: Suppuration of petrous pyramid: symptomatology, pathology and surgical treatment. Ann Otol Rhinol Laryngol. 1931, 40: 396-414.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1109_CR11","first-page":"1","volume":"46","author":"J Ramadier","year":"1933","unstructured":"Ramadier J: Les ost\u00e9ites profondes du rocher (Petrosite-Rochente). Bull Loc Franc ORL. 1933, 46: 1-18.","journal-title":"Bull Loc Franc ORL"},{"key":"1109_CR12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3109\/00016483209127994","volume":"17","author":"P Frenckner","year":"1932","unstructured":"Frenckner P: Some remarks on the treatment of apicitis (petrositis) with and without Gradenigo's syndrome. Acta Otolaryngol (Stockh). 1932, 17: 97-120. 10.3109\/00016483209127994.","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"1109_CR13","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1001\/archotol.1931.04230020072005","volume":"13","author":"WP Eagleton","year":"1931","unstructured":"Eagleton WP: Unlocking the petrous pyramid for localized bulbar meningitis, secondary to suppuration of the petrous apex. Arch Otolaryngol. 1931, 13: 386-398.","journal-title":"Arch Otolaryngol"},{"key":"1109_CR14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1001\/archotol.1937.00650020342008","volume":"26","author":"RM Dearmin","year":"1937","unstructured":"Dearmin RM: Logical surgical approach to tip cells of petrous pyramid. 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