{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:51:55Z","timestamp":1790016715544,"version":"4.0.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:00:00Z","timestamp":1277078400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Radiation-induced nonmelanoma skin cancer was first reported seven years after the discovery of X-rays, but has received relatively little consideration in the literature. Specifically, nonmelanoma skin cancer after conservative surgery and radiation for early stage breast cancer has not been well studied. We report the case of a woman who developed squamous cell carcinoma of the nipple nine years after conservative surgery and radiation for ductal carcinoma <jats:italic>in situ<\/jats:italic> of the ipsilateral breast. We also review the relevant literature available to date.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 66-year-old African-American woman presented to the hospital with a non-healing ulcer of the right nipple. Her past medical history was significant for right breast ductal carcinoma <jats:italic>in situ<\/jats:italic> for which she had undergone lumpectomy and whole breast radiation therapy nine years previously. Mammography and magnetic resonance imaging studies were negative for recurrent breast cancer. However, the latter demonstrated abnormal enhancement in the nipple-areolar region. An incisional biopsy of the lesion demonstrated invasive squamous cell carcinoma. Subsequently, the patient underwent wide excision of the nipple-areolar complex. Sentinel lymph-node biopsy was offered but our patient declined. She was considered to have local disease and hence no further treatment was recommended.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case represents the first reported occurrence of squamous cell carcinoma of the nipple to follow conservative surgery and radiation for ductal carcinoma <jats:italic>in situ<\/jats:italic> of the ipsilateral breast. It is likely that radiation overexposure resulted in a radiation burn and subsequent radiodermatitis, placing it at risk for squamous cell carcinoma. A diagnosis of squamous cell carcinoma should be considered in a patient with a nipple lesion following radiation therapy for breast cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-4-186","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T19:01:51Z","timestamp":1279652511000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Squamous cell carcinoma of the nipple following radiation therapy for ductal carcinoma in situ: a case report"],"prefix":"10.1186","volume":"4","author":[{"given":"Catherine E","family":"Loveland-Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R","family":"Bankhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen J","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,21]]},"reference":[{"key":"1143_CR1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1200\/JCO.1996.14.5.1558","volume":"14","author":"R Arriagada","year":"1996","unstructured":"Arriagada R, Le MG, Rochard F, Contesso G: Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. J Clin Oncol. 1996, 14: 1558-64.","journal-title":"J Clin Oncol"},{"key":"1143_CR2","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1056\/NEJMoa020989","volume":"347","author":"U Veronesi","year":"2002","unstructured":"Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aquilar M, Marubini E: Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002, 347: 1227-32. 10.1056\/NEJMoa020989.","journal-title":"N Engl J Med"},{"key":"1143_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/jnci\/djj002","volume":"98","author":"V Gebski","year":"2006","unstructured":"Gebski V, Lagleva M, Keech A, Simes J, Langlands AO: Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: a clinical perspective. J Natl Cancer Inst. 2006, 98: 26-38. 10.1093\/jnci\/djj002.","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"1143_CR4","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/sj.bjc.6602084","volume":"91","author":"R Roychoudhuri","year":"2004","unstructured":"Roychoudhuri R, Evans H, Robinson D, Moller H: Radiation-induced malignancies following radiotherapy for breast cancer. Br J Cancer. 2004, 91 (5): 868-72.","journal-title":"Br J Cancer"},{"key":"1143_CR5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0360-3016(01)01665-0","volume":"51","author":"B Fowble","year":"2001","unstructured":"Fowble B, Hanlon A, Freedman G, Nicolaou N, Anderson P: Second cancers after conservative surgery and radiation for stages I-II breast cancer: identifying a subset of women at increased risk. Int J Radiat Oncol Biol Phys. 2001, 51: 679-90.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1143_CR6","first-page":"1245","volume":"13","author":"AI Neugut","year":"1999","unstructured":"Neugut AI, Weinberg MD, Ahsan H, Rescigno J: Carcinogenic effects of radiotherapy for breast cancer. Oncology. 1999, 13: 1245-52.","journal-title":"Oncology"},{"key":"1143_CR7","first-page":"106","volume":"6","author":"A Frieben","year":"1902","unstructured":"Frieben A: Demonstration eines cancroids des rechten handruckens, das sich nach langedauernder einwirkung von rontgenstrahlen entwickelt hatte. Fortschr Rontgestr. 1902, 6: 106-11.","journal-title":"Fortschr Rontgestr"},{"key":"1143_CR8","unstructured":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Basal Cell and Squamous Cell Skin Cancers. V.1.2008. http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/nmsc.pdf"},{"key":"1143_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S1085-5629(98)80002-3","volume":"17","author":"GD Goldman","year":"1998","unstructured":"Goldman GD: Squamous cell cancer: a practical approach. Semin Cutan Med Surg. 1998, 17: 80-95. 10.1016\/S1085-5629(98)80002-3.","journal-title":"Semin Cutan Med Surg"},{"key":"1143_CR10","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1200\/JCO.2005.06.237","volume":"23","author":"JL Perkins","year":"2005","unstructured":"Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer ZE, Robison LL, Mertens AC: Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. J Clin Oncol. 2005, 23: 3733-3741. 10.1200\/JCO.2005.06.237.","journal-title":"J Clin Oncol"},{"key":"1143_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1001\/archsurg.1989.01410010125024","volume":"124","author":"MJ Edwards","year":"1989","unstructured":"Edwards MJ, Hirsch RM, Broadwater JR, Netscher DT, Ames FC: Squamous cell carcinoma arising in previously burned or irradiated skin. Arch Surg. 1989, 124: 115-117.","journal-title":"Arch Surg"},{"key":"1143_CR12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/0360-3016(92)90918-8","volume":"23","author":"SM Pierce","year":"1992","unstructured":"Pierce SM, Recht A, Lingos TI, Abner A, Vicini F, Silver B, Herzog A, Harris JR: Long-term radiation complications following conservative surgery and radiation therapy in patients with early stage breast cancer. Int J Radiat Oncol Biol Phys. 1992, 23: 1085-1086.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1143_CR13","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","volume":"26","author":"JP Pignol","year":"2008","unstructured":"Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, Vu TT, Truong P, Ackerman I, Paszat L: A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008, 26: 2085-2092. 10.1200\/JCO.2007.15.2488.","journal-title":"J Clin Oncol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-4-186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-1947-4-186\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-4-186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-4-186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T05:50:55Z","timestamp":1630475455000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/1752-1947-4-186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,21]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["1143"],"URL":"https:\/\/doi.org\/10.1186\/1752-1947-4-186","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,21]]},"assertion":[{"value":"22 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"186"}}