{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:21:08Z","timestamp":1792452068165,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Primary hyperparathyroidism is a common endocrine disorder characterized by elevated parathyroid hormone levels, which cause continuous osteoclastic bone resorption. Giant cell tumor of bone is an expansile osteolytic tumor that contains numerous osteoclast-like giant cells. There are many similarities in the radiological and histological features of giant cell tumor of bone and brown tumor. This is a rare benign focal osteolytic process most commonly caused by hyperparathyroidism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We report the unusual case of a 40-year-old Caucasian woman in which primary hyperparathyroidism was diagnosed after surgical ablation of a costal mass. The mass was suspected of being neoplastic and histopathology was compatible with a giant cell tumor of bone. On the basis of the biochemical results (including serum calcium, phosphorous and intact parathyroid hormone levels) primary hyperparathyroidism was suspected and a brown tumor secondary to refractory hyperparathyroidism was diagnosed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Since giant cell tumor is a bone neoplasm that has major implications for the patient, the standard laboratory tests in patients with bone lesions are important for a correct diagnosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-1947-5-596","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T19:57:29Z","timestamp":1325102249000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Primary hyperparathyroidism diagnosed after surgical ablation of a costal mass mistaken for giant-cell bone tumor: a case report"],"prefix":"10.1186","volume":"5","author":[{"given":"Lara","family":"Vera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Dolcino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Oddo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Gualco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Minuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Giusti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"1944_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cccn.2004.10.003","volume":"353","author":"NA Youanes","year":"2005","unstructured":"Youanes NA, Shafagoij Y, Khatib F, Ababneh M: Laboratory screening for hyperparathyroidism. Clin Chim Acta. 2005, 353: 1-12. 10.1016\/j.cccn.2004.10.003.","journal-title":"Clin Chim Acta"},{"key":"1944_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4065\/77.1.87","volume":"77","author":"AE Kearns","year":"2002","unstructured":"Kearns AE, Thompson GB: Medical and surgical management of hyperparathyroidism. Mayo Clin Proc. 2002, 77: 87-89. 10.4065\/77.1.87.","journal-title":"Mayo Clin Proc"},{"key":"1944_CR3","doi-asserted-by":"publisher","first-page":"7285","DOI":"10.4076\/1752-1947-3-7285","volume":"3","author":"G Campuzano-Zuluaga","year":"2009","unstructured":"Campuzano-Zuluaga G, Velasco-Perez W, Marian-Zuluaga JI: A 60-year-old man with chronic renal failure and a costal mass: a case report and review of the literature. J Med Case Rep. 2009, 3: 7285-10.4076\/1752-1947-3-7285.","journal-title":"J Med Case Rep"},{"key":"1944_CR4","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1067\/msy.2002.128693","volume":"132","author":"MS Sywak","year":"2002","unstructured":"Sywak MS, Knowlton ST, Pasieka JL, Parsons LL, Jones J: Do the National Institutes of Health Consensus Guidelines for Parathyroidectomy predict symptom severity and surgical outcome in patients with primary hyperparathyroidism?. Surgery. 2002, 132: 1013-1019. 10.1067\/msy.2002.128693.","journal-title":"Surgery"},{"key":"1944_CR5","doi-asserted-by":"publisher","first-page":"5138","DOI":"10.1210\/jcem.86.11.7994","volume":"86","author":"MR Rubin","year":"2001","unstructured":"Rubin MR, Livolsi VA, Bandiera F, Caldas G, Bilezikian JP: Tc99 m-sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease. J Clin Endocrin Metab. 2001, 86: 5138-5141. 10.1210\/jc.86.11.5138.","journal-title":"J Clin Endocrin Metab"},{"key":"1944_CR6","first-page":"265","volume":"22","author":"T Takeshita","year":"2004","unstructured":"Takeshita T, Tanaka H, Harasawa A, Kaminaga T, Imamura T, Furui S: Brown tumor of the sphenoid sinus in a patient with secondary hyperparathyroidism: CT and MR imaging findings. Rad Med. 2004, 22: 265-268.","journal-title":"Rad Med"},{"key":"1944_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0196-0709(96)90075-7","volume":"17","author":"JS Keyser","year":"1996","unstructured":"Keyser JS, Postma GN: Brown tumor of the mandible. Am J Otolaryngol. 1996, 17: 407-409. 10.1016\/S0196-0709(96)90075-7.","journal-title":"Am J Otolaryngol"},{"key":"1944_CR8","first-page":"1118","volume-title":"Current Medical Diagnosis & Treatment","author":"P Fitzgerald","year":"2000","unstructured":"Fitzgerald P: Endocrinology. Current Medical Diagnosis & Treatment. Edited by: Tierney LM, McPhee Sj, Papadakis MA. 2000, Stamford, CT: Appleton & Large, 1118-1121. 39","edition":"39"},{"key":"1944_CR9","first-page":"84","volume":"15","author":"EH Rosemberg","year":"1962","unstructured":"Rosemberg EH, Guralnick WC: Hyperparathyroidism: a review of 220 proved cases, with special emphasis on findings in the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1962, 15: 84-94.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"1944_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1148\/radiology.147.1.6828717","volume":"147","author":"PM Som","year":"1983","unstructured":"Som PM, Lawson W, Cohen BA: Giant cell lesions of the facial bones. Radiology. 1983, 147: 129-132.","journal-title":"Radiology"},{"key":"1944_CR11","doi-asserted-by":"publisher","first-page":"7495","DOI":"10.4076\/1752-1947-3-7495","volume":"3","author":"E Proimos","year":"2009","unstructured":"Proimos E, Chimona T, Tamiolakis D, Tzanakakis MG, Papadakis CE: Brown tumor of the maxillary sinus in a patient with primary hyperparathyroidism: a case report. J Med Case Rep. 2009, 3: 7495-10.4076\/1752-1947-3-7495.","journal-title":"J Med Case Rep"},{"key":"1944_CR12","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/1471-2407-10-462","volume":"10","author":"M Balke","year":"2010","unstructured":"Balke M, Campanacci L, Gebert C, Picci P, Gibbons M, Taylor R, Hogendoorn P, Kroep J, Wass J, Athanasou N: Bisphosphonate treatment of aggressive primary, reccurent and metastatic giant cell tumor of bone. BMC Cancer. 2010, 10: 462-10.1186\/1471-2407-10-462.","journal-title":"BMC Cancer"},{"key":"1944_CR13","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.humpath.2005.07.005","volume":"36","author":"YS Lau","year":"2005","unstructured":"Lau YS, Sabokbar A, Gibbons CL, Giele H, Athanasou N: Phenotypic and molecular studies on giant cell tumours of bone and soft tissues. Hum Pathol. 2005, 36: 945-954. 10.1016\/j.humpath.2005.07.005.","journal-title":"Hum Pathol"},{"key":"1944_CR14","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1002\/cncr.11359","volume":"97","author":"F Bertoni","year":"2003","unstructured":"Bertoni F, Bacchini P, Staals EL: Malignancy in giant cell tumor of bone. Cancer. 2003, 97: 2520-2529. 10.1002\/cncr.11359.","journal-title":"Cancer"},{"key":"1944_CR15","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1053\/joms.2001.27533","volume":"59","author":"DK Kar","year":"2001","unstructured":"Kar DK, Gupta SK, Agarwal A, Mishra SK: Brown tumor of the palata and mandible in association with primary hyperparathyroidism. J Oral Maxillofac Surg. 2001, 59: 1352-1354. 10.1053\/joms.2001.27533.","journal-title":"J Oral Maxillofac Surg"},{"key":"1944_CR16","first-page":"169","volume":"10","author":"J Fernandez-Sanroman","year":"2005","unstructured":"Fernandez-Sanroman J, Anton-Badiola IM, Costas-Lopez A: Brown tumor of the mandible as first manifestation of primary hyperparathyroidism: diagnosis and treatment. Med Oral Patol Oral Cir Bucal. 2005, 10: 169-170.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"1944_CR17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00508-006-0566-5","volume":"118","author":"PS Pahlava","year":"2006","unstructured":"Pahlava PS, Severin MC: Parathyroid carcinoma: a rare case with mandibular brown tumor. Wien Klin Wochenschr. 2006, 118: 175-179. 10.1007\/s00508-006-0566-5.","journal-title":"Wien Klin Wochenschr"},{"key":"1944_CR18","first-page":"230","volume":"67","author":"A Azria","year":"2000","unstructured":"Azria A, Beaudreuil J, Juquel JP, Quillard A, Bardin T: Brown tumor of the spine revealing secondary hyperparathyroidism. Report of a case. Joint Bone Spine. 2000, 67: 230-233.","journal-title":"Joint Bone Spine"},{"key":"1944_CR19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1590\/S1808-86942010000300022","volume":"76","author":"MC Pinto","year":"2010","unstructured":"Pinto MC, Sass SM, Sampaio CP, Campos DS: Brown tumor in a patient with hyperparathyroidism secondary to chronic renal failure. Braz J Otorhinolaryngol. 2010, 76: 404-10.1590\/S1808-86942010000300022.","journal-title":"Braz J Otorhinolaryngol"},{"key":"1944_CR20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1365-2796.2004.01422.x","volume":"257","author":"JP Bilezikian","year":"2005","unstructured":"Bilezikian JP, Brandi ML, Rubin M, Silverberg SJ: Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Internal Med. 2005, 257: 6-17. 10.1111\/j.1365-2796.2004.01422.x.","journal-title":"J Internal Med"},{"key":"1944_CR21","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s11604-006-0068-4","volume":"24","author":"T Takeshita","year":"2006","unstructured":"Takeshita T, Takeshita K, Abe S, Takami H, Imamura T, Furui S: Brown tumor with fluid-fluid levels in a patient with primary hyperparathyroidism: radiological finding. Radiat Med. 2006, 24: 631-634. 10.1007\/s11604-006-0068-4.","journal-title":"Radiat Med"},{"key":"1944_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/01.rlu.0000162970.49398.4c","volume":"30","author":"AF Yapar","year":"2005","unstructured":"Yapar AF, Aydin M, Reyhan M, Bal N, Yapar Z, Yologlu NA: Simultaneous visualization of a mandibular brown tumor with a large parathyroid adenoma on Tc-99 m MIBI imaging. Clin Nucl Med. 2005, 30: 433-435. 10.1097\/01.rlu.0000162970.49398.4c.","journal-title":"Clin Nucl Med"},{"key":"1944_CR23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S1297-319X(02)00439-6","volume":"69","author":"M Franco","year":"2002","unstructured":"Franco M, Bendini JC, Albano L, Barrillon D, Cassuto E, Bracco J: Radiographic follow-up of a phalangeal brown tumor. Joint Bone Spine. 2002, 69: 506-510. 10.1016\/S1297-319X(02)00439-6.","journal-title":"Joint Bone Spine"},{"key":"1944_CR24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/PL00013807","volume":"159","author":"A Bereket","year":"2000","unstructured":"Bereket A, Casur Y, Firat P, Yordam N: Brown tumor as a complication of secondary hyperparathyroidism severe long-lasting vitamin D deficient rickets. Eur J Pediatr. 2000, 159: 70-73. 10.1007\/PL00013807.","journal-title":"Eur J Pediatr"},{"key":"1944_CR25","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1053\/joms.2003.50142","volume":"61","author":"H Yamazaki","year":"2003","unstructured":"Yamazaki H, Ota Y, Aoki T, Karakida K: Brown tumor of the maxilla and mandible. Progressive mandibular brown tumor after removal of parathyroid adenoma. J Oral Maxillofac Surg. 2003, 61: 719-722. 10.1053\/joms.2003.50142.","journal-title":"J Oral Maxillofac Surg"},{"key":"1944_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/000348949910800114","volume":"108","author":"SN Scott","year":"1999","unstructured":"Scott SN, Graham SM, Sato Y, Robinson RA: Brown tumor of the palate in a patient with primary hyperparathyroidism. Ann Otol Rhinol Laryngol. 1999, 108: 91-94.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1944_CR27","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0901-5027(00)80079-X","volume":"29","author":"EM Martinez-Gravidia","year":"2000","unstructured":"Martinez-Gravidia EM, Bagan JV, Milian-Masanet MA, Lloria de Miguel E, P\u00e9rez-Vall\u00e9s A: Highly aggressive brown tumor of the maxilla as first manifestation of primary hyperparathyroidis. Int J Oral Maxillofac Surg. 2000, 29: 447-449. 10.1016\/S0901-5027(00)80079-X.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1944_CR28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/014556130508400714","volume":"84","author":"MM Lessa","year":"2005","unstructured":"Lessa MM: Brown tumor of the facial bones: case report and literature review. Ear Nose Throat J. 2005, 84: 42-44.","journal-title":"Ear Nose Throat J"},{"key":"1944_CR29","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/j.clinthera.2004.12.011","volume":"26","author":"AL Francisco","year":"2004","unstructured":"Francisco AL: Secondary hyperparathyroidism: review of the disease and its treatment. Clin Ther. 2004, 26: 1976-10.1016\/j.clinthera.2004.12.011.","journal-title":"Clin Ther"},{"key":"1944_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1631\/jzus.B0820372","volume":"10","author":"M Giusti","year":"2009","unstructured":"Giusti M, Dolcino M, Vera L, Ghiara C, Massaro F, Fazzuoli L, Ferone D, Mussap M, Miunto F: Institutional experience of PHT evaluation on fine-needle washing after aspiration biopsy to locate hyperfunctioning parathyroid tissue. J Zhejiang Univ Sci B. 2009, 10: 323-330. 10.1631\/jzus.B0820372.","journal-title":"J Zhejiang Univ Sci B"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-5-596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-1947-5-596\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-5-596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-5-596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T18:08:22Z","timestamp":1630519702000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/1752-1947-5-596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["1944"],"URL":"https:\/\/doi.org\/10.1186\/1752-1947-5-596","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"4 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"596"}}