{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:59:54Z","timestamp":1790758794772,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1752-1947-8-155","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T11:03:09Z","timestamp":1400497389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neuromyelitis optica presenting with relapses under treatment with natalizumab: a case report"],"prefix":"10.1186","volume":"8","author":[{"given":"De-Hyung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra B","family":"Laemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Waschbisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Struffert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Maih\u00f6fner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf Andreas","family":"Linker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"2786_CR1","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1212\/01.wnl.0000216139.44259.74","volume":"66","author":"DM Wingerchuk","year":"2006","unstructured":"Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG: Revised diagnostic criteria for neuromyelitis optica. Neurology. 2006, 66: 1485-1489. 10.1212\/01.wnl.0000216139.44259.74.","journal-title":"Neurology"},{"key":"2786_CR2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1084\/jem.20050304","volume":"204","author":"VA Lennon","year":"2005","unstructured":"Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR: IgG marker of optic- spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med. 2005, 204: 473-477.","journal-title":"J Exp Med"},{"key":"2786_CR3","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1177\/1352458506070732","volume":"13","author":"C Papeix","year":"2007","unstructured":"Papeix C, Vidal JS, de Seze J, Pierrot-Deseilligny C, Tourbah A, Stankoff B, Lebrun C, Moreau T, Vermersch P, Fontaine B, Lyon-Caen O, Gout O: Immunosuppressive therapy is more effective than interferon in neuromyelitis optica. Mult Scler. 2007, 13: 256-259. 10.1177\/1352458506070732.","journal-title":"Mult Scler"},{"key":"2786_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00415-013-7169-7","volume":"261","author":"C Trebst","year":"2014","unstructured":"Trebst C, Jarius S, Berthele A, Paul F, Schippling S, Wildemann B, Borisow N, Kleiter I, Aktas O, K\u00fcmpfel T, Neuromyelitis Optica Study Group (NEMOS): Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS). J Neurol. 2014, 261: 1-16. 10.1007\/s00415-013-7169-7.","journal-title":"J Neurol"},{"key":"2786_CR5","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1001\/archneur.65.11.noc80069","volume":"65","author":"A Jacob","year":"2008","unstructured":"Jacob A, Weinshenker BG, Violich I, McLinskey N, Krupp L, Fox RJ, Wingerchuk DM, Boggild M, Constantinescu CS, Miller A, De Angelis T, Matiello M, Cree BA: Treatment of neuromyelitis optica with rituximab: retrospective analysis of 25 patients. Arch Neurol. 2008, 65: 1443-1448.","journal-title":"Arch Neurol"},{"key":"2786_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1177\/1352458511421185","volume":"18","author":"MH Barnett","year":"2012","unstructured":"Barnett MH, Prineas JW, Buckland ME, Parratt JD, Pollard JD: Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy. Mult Scler. 2012, 18: 108-112. 10.1177\/1352458511421185.","journal-title":"Mult Scler"},{"key":"2786_CR7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1001\/jamaneurol.2013.1246","volume":"70","author":"I Ayzenberg","year":"2013","unstructured":"Ayzenberg I, Kleiter I, Schr\u00f6der A, Hellwig K, Chan A, Yamamura T, Gold R: Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy. JAMA Neurol. 2013, 70: 394-397. 10.1001\/jamaneurol.2013.1246.","journal-title":"JAMA Neurol"},{"key":"2786_CR8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-9-14","volume":"19","author":"S Jarius","year":"2012","unstructured":"Jarius S, Ruprecht K, Wildemann B, Kuempfel T, Ringelstein M, Geis C, Kleiter I, Kleinschnitz C, Berthele A, Brettschneider J, Hellwig K, Hemmer B, Linker RA, Lauda F, Mayer CA, Tumani H, Melms A, Trebst C, Stangel M, Marziniak M, Hoffmann F, Schippling S, Faiss JH, Neuhaus O, Ettrich B, Zentner C, Guthke K, Hofstadt-van Oy U, Reuss R, Pellkofer H: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients. J Neuroinflammation. 2012, 19: 14-","journal-title":"J Neuroinflammation"},{"key":"2786_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1001\/archneurol.2011.216","volume":"69","author":"I Kleiter","year":"2012","unstructured":"Kleiter I, Hellwig K, Berthele A, K\u00fcmpfel T, Linker RA, Hartung HP, Paul F, Aktas O, Neuromyelitis Optica Study Group: Failure of natalizumab to prevent relapses in neuromyelitis optica. Arch Neurol. 2012, 69: 239-245. 10.1001\/archneurol.2011.216.","journal-title":"Arch Neurol"},{"key":"2786_CR10","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1212\/WNL.0b013e31826845fe","volume":"79","author":"A Jacob","year":"2012","unstructured":"Jacob A, Hutchinson M, Elsone L, Kelly S, Ali R, Saukans I, Tubridy N, Boggild M: Does natalizumab therapy worsen neuromyelitis optica?. Neurology. 2012, 79: 1065-1066. 10.1212\/WNL.0b013e31826845fe.","journal-title":"Neurology"},{"key":"2786_CR11","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1007\/s00415-013-6965-4","volume":"260","author":"M Jury\u0144czyk","year":"2013","unstructured":"Jury\u0144czyk M, Zaleski K, Selmaj K: Natalizumab and the development of extensive brain lesions in neuromyelitis optica. J Neurol. 2013, 260: 1919-1921. 10.1007\/s00415-013-6965-4.","journal-title":"J Neurol"},{"key":"2786_CR12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1001\/archneurol.2012.1138","volume":"69","author":"R Govindarajan","year":"2012","unstructured":"Govindarajan R, Salgado E: Is it too early to predict the failure of natalizumab in NMO?. Arch Neurol. 2012, 69: 1085-","journal-title":"Arch Neurol"},{"key":"2786_CR13","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1001\/archneurol.2011.154","volume":"68","author":"SH Kim","year":"2011","unstructured":"Kim SH, Kim W, Li XF, Jung IJ, Kim HJ: Repeated treatment with rituximab based on the assessment of peripheral circulating memory B cells in patients with relapsing neuromyelitis optica over 2\u00a0years. Arch Neurol. 2011, 68: 1412-1420. 10.1001\/archneurol.2011.154.","journal-title":"Arch Neurol"},{"key":"2786_CR14","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1212\/01.wnl.0000327671.91357.96","volume":"71","author":"M Krumbholz","year":"2008","unstructured":"Krumbholz M, Meinl I, K\u00fcmpfel T, Hohlfeld R, Meinl E: Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology. 2008, 71: 1350-1354. 10.1212\/01.wnl.0000327671.91357.96.","journal-title":"Neurology"},{"key":"2786_CR15","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1001\/archneurol.2012.545","volume":"69","author":"DB Bichuetti","year":"2012","unstructured":"Bichuetti DB, Oliveira EM, Boulos Fde C, Gabbai AA: Lack of response to pulse cyclophosphamide in neuromyelitis optica: evaluation of 7 patients. Arch Neurol. 2012, 69: 938-939. 10.1001\/archneurol.2012.545.","journal-title":"Arch Neurol"},{"key":"2786_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/ana.20770","volume":"59","author":"BG Weinshenker","year":"2006","unstructured":"Weinshenker BG, Wingerchuk DM, Vukusic S, Linbo L, Pittock SJ, Lucchinetti CF, Lennon VA: Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol. 2006, 59: 566-569. 10.1002\/ana.20770.","journal-title":"Ann Neurol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-8-155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-1947-8-155\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-8-155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-1947-8-155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T19:53:45Z","timestamp":1649015625000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/1752-1947-8-155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["2786"],"URL":"https:\/\/doi.org\/10.1186\/1752-1947-8-155","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]},"assertion":[{"value":"30 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"155"}}