{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:15:24Z","timestamp":1776701724577,"version":"3.51.2"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T00:00:00Z","timestamp":1273708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Trauma Manage Outcomes"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The goal when resuscitating trauma patients is to achieve adequate tissue perfusion. One parameter of tissue perfusion is tissue oxygen saturation (StO<jats:sub>2<\/jats:sub>), as measured by near infrared spectroscopy. Using a commercially available device, we investigated whether clinically relevant blood loss of 500 ml in healthy volunteers can be detected by changes in StO<jats:sub>2<\/jats:sub> after a standardized ischemic event.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We performed occlusion of the brachial artery for 3 minutes in 20 healthy female blood donors before and after blood donation. StO<jats:sub>2<\/jats:sub> and total oxygenated tissue hemoglobin (O<jats:sub>2<\/jats:sub>Hb) were measured continuously at the thenar eminence. 10 healthy volunteers were assessed in the same way, to examine whether repeated vascular occlusion without blood donation exhibits time dependent effects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Blood donation caused a substantial decrease in systolic blood pressure, but did not affect resting StO<jats:sub>2<\/jats:sub> and O<jats:sub>2<\/jats:sub>Hb values. No changes were measured in the blood donor group in the reaction to the vascular occlusion test, but in the control group there was an increase in the O<jats:sub>2<\/jats:sub>Hb rate of recovery during the reperfusion phase.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>StO<jats:sub>2<\/jats:sub> measured at the thenar eminence seems to be insensitive to blood loss of 500 ml in this setting. Probably blood loss greater than this might lead to detectable changes guiding the treating physician. The exact cut off for detectable changes and the time effect on repeated vascular occlusion tests should be explored further. Until now no such data exist.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-2897-4-5","type":"journal-article","created":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T19:24:39Z","timestamp":1273778679000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["500 ml of blood loss does not decrease non-invasive tissue oxygen saturation (StO2) as measured by near infrared spectroscopy - A hypothesis generating pilot study in healthy adult women"],"prefix":"10.1186","volume":"4","author":[{"given":"Victor","family":"Jeger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan M","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristomenis K","family":"Exadaktylos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,13]]},"reference":[{"key":"34_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s001340050328","volume":"23","author":"C Hamilton-Davies","year":"1997","unstructured":"Hamilton-Davies C, Mythen MG, Salmon JB, Jacobson D, Shukla A, Webb AR: Comparison of commonly used clinical indicators of hypovolaemia with gastrointestinal tonometry. Intensive Care Med. 1997, 23: 276-281. 10.1007\/s001340050328.","journal-title":"Intensive Care Med"},{"key":"34_CR2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1097\/00005373-200104000-00006","volume":"50","author":"SM Cohn","year":"2001","unstructured":"Cohn SM, Varela JE, Giannotti G, Dolich MO, Brown M, Feinstein A, McKenney MG, Spalding P: Splanchnic perfusion evaluation during hemorrhage and resuscitation with gastric near-infrared spectroscopy. J Trauma. 2001, 50: 629-634. 10.1097\/00005373-200104000-00006. discussion 634-625","journal-title":"J Trauma"},{"key":"34_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1067\/msy.2001.111695","volume":"129","author":"JE Varela","year":"2001","unstructured":"Varela JE, Cohn SM, Giannotti GD, Dolich MO, Ramon H, Wiseberg JA, McKenney M: Near-infrared spectroscopy reflects changes in mesenteric and systemic perfusion during abdominal compartment syndrome. Surgery. 2001, 129: 363-370. 10.1067\/msy.2001.111695.","journal-title":"Surgery"},{"key":"34_CR4","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.1097\/00005373-200301000-00024","volume":"54","author":"NF Chaisson","year":"2003","unstructured":"Chaisson NF, Kirschner RA, Deyo DJ, Lopez JA, Prough DS, Kramer GC: Near-infrared spectroscopy-guided closed-loop resuscitation of hemorrhage. J Trauma. 2003, 54: S183-192. 10.1097\/00005373-200301000-00024.","journal-title":"J Trauma"},{"key":"34_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/TA.0b013e31802eb817","volume":"62","author":"SM Cohn","year":"2007","unstructured":"Cohn SM, Nathens AB, Moore FA, Rhee P, Puyana JC, Moore EE, Beilman GJ: Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation. J Trauma. 2007, 62: 44-54. 10.1097\/TA.0b013e31802eb817. discussion 54-45","journal-title":"J Trauma"},{"key":"34_CR6","first-page":"420","volume":"4","author":"DE Taylor","year":"1996","unstructured":"Taylor DE, Simonson SG: Use of near-infrared spectroscopy to monitor tissue oxygenation. New Horiz. 1996, 4: 420-425.","journal-title":"New Horiz"},{"key":"34_CR7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/00005373-200003000-00005","volume":"48","author":"G Giannotti","year":"2000","unstructured":"Giannotti G, Cohn SM, Brown M, Varela JE, McKenney MG, Wiseberg JA: Utility of near-infrared spectroscopy in the diagnosis of lower extremity compartment syndrome. J Trauma. 2000, 48: 396-399. 10.1097\/00005373-200003000-00005. discussion 399-401","journal-title":"J Trauma"},{"key":"34_CR8","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1046\/j.1365-201x.2000.00713.x","volume":"168","author":"R Boushel","year":"2000","unstructured":"Boushel R, Piantadosi CA: Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand. 2000, 168: 615-622. 10.1046\/j.1365-201x.2000.00713.x.","journal-title":"Acta Physiol Scand"},{"key":"34_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/cs1010021","volume":"101","author":"MC van Beekvelt","year":"2001","unstructured":"van Beekvelt MC, Borghuis MS, van Engelen BG, Wevers RA, Colier WN: Adipose tissue thickness affects in vivo quantitative near-IR spectroscopy in human skeletal muscle. Clin Sci (Lond). 2001, 101: 21-28. 10.1042\/CS20000247.","journal-title":"Clin Sci (Lond)"},{"key":"34_CR10","first-page":"311","volume":"81","author":"RD Rothoerl","year":"2002","unstructured":"Rothoerl RD, Faltermeier R, Burger R, Woertgen C, Brawanski A: Dynamic correlation between tissue PO2 and near infrared spectroscopy. Acta Neurochir Suppl. 2002, 81: 311-313.","journal-title":"Acta Neurochir Suppl"},{"key":"34_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2170\/physiolsci.RP001906","volume":"56","author":"G Pichler","year":"2006","unstructured":"Pichler G, Urlesberger B, Jirak P, Zotter H, Muller W: Forearm oxygen consumption and forearm blood flow in healthy children and adolescents measured by near infrared spectroscopy. J Physiol Sci. 2006, 56: 191-194. 10.2170\/physiolsci.RP001906.","journal-title":"J Physiol Sci"},{"key":"34_CR12","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s00134-007-0739-3","volume":"33","author":"J Creteur","year":"2007","unstructured":"Creteur J, Carollo T, Soldati G, Buchele G, De Backer D, Vincent JL: The prognostic value of muscle StO2 in septic patients. Intensive Care Med. 2007, 33: 1549-1556. 10.1007\/s00134-007-0739-3.","journal-title":"Intensive Care Med"},{"key":"34_CR13","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/01.TA.0000158269.68409.1C","volume":"58","author":"BA Crookes","year":"2005","unstructured":"Crookes BA, Cohn SM, Bloch S, Amortegui J, Manning R, Li P, Proctor MS, Hallal A, Blackbourne LH, Benjamin R: Can near-infrared spectroscopy identify the severity of shock in trauma patients?. J Trauma. 2005, 58: 806-813. 10.1097\/01.TA.0000158269.68409.1C. discussion 813-806","journal-title":"J Trauma"},{"key":"34_CR14","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1007\/s00134-008-1145-1","volume":"34","author":"H Gomez","year":"2008","unstructured":"Gomez H, Torres A, Polanco P, Kim HK, Zenker S, Puyana JC, Pinsky MR: Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response. Intensive Care Med. 2008, 34: 1600-1607. 10.1007\/s00134-008-1145-1.","journal-title":"Intensive Care Med"},{"key":"34_CR15","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1213\/01.ane.0000286233.48111.d8","volume":"105","author":"P Toledo","year":"2007","unstructured":"Toledo P, McCarthy RJ, Hewlett BJ, Fitzgerald PC, Wong CA: The accuracy of blood loss estimation after simulated vaginal delivery. Anesth Analg. 2007, 105: 1736-1740. 10.1213\/01.ane.0000286233.48111.d8. table of contents","journal-title":"Anesth Analg"},{"key":"34_CR16","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/00024382-200211000-00009","volume":"18","author":"F Torella","year":"2002","unstructured":"Torella F, Cowley RD, Thorniley MS, McCollum CN: Regional tissue oxygenation during hemorrhage: can near infrared spectroscopy be used to monitor blood loss?. Shock. 2002, 18: 440-444. 10.1097\/00024382-200211000-00009.","journal-title":"Shock"},{"key":"34_CR17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1152\/japplphysiol.00600.2007","volume":"104","author":"BR Soller","year":"2008","unstructured":"Soller BR, Yang Y, Soyemi OO, Ryan KL, Rickards CA, Walz JM, Heard SO, Convertino VA: Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans. J Appl Physiol. 2008, 104: 475-481. 10.1152\/japplphysiol.00600.2007.","journal-title":"J Appl Physiol"},{"key":"34_CR18","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1177\/000313480807401027","volume":"74","author":"J Smith","year":"2008","unstructured":"Smith J, Bricker S, Putnam B: Tissue oxygen saturation predicts the need for early blood transfusion in trauma patients. Am Surg. 2008, 74: 1006-1011.","journal-title":"Am Surg"},{"key":"34_CR19","doi-asserted-by":"publisher","first-page":"034017","DOI":"10.1117\/1.1925250","volume":"10","author":"DE Myers","year":"2005","unstructured":"Myers DE, Anderson LD, Seifert RP, Ortner JP, Cooper CE, Beilman GJ, Mowlem JD: Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy. J Biomed Opt. 2005, 10: 034017-10.1117\/1.1925250.","journal-title":"J Biomed Opt"},{"key":"34_CR20","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/01.shk.0000239779.25775.e4","volume":"27","author":"DE Skarda","year":"2007","unstructured":"Skarda DE, Mulier KE, Myers DE, Taylor JH, Beilman GJ: Dynamic near-infrared spectroscopy measurements in patients with severe sepsis. Shock. 2007, 27: 348-353. 10.1097\/01.shk.0000239779.25775.e4.","journal-title":"Shock"},{"key":"34_CR21","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/01.CCM.0000295586.83787.7E","volume":"36","author":"BR Soller","year":"2008","unstructured":"Soller BR, Ryan KL, Rickards CA, Cooke WH, Yang Y, Soyemi OO, Crookes BA, Heard SO, Convertino VA: Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans. Crit Care Med. 2008, 36: 176-182. 10.1097\/01.CCM.0000295586.83787.7E.","journal-title":"Crit Care Med"},{"key":"34_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1006\/jsre.2000.5987","volume":"94","author":"L Gurke","year":"2000","unstructured":"Gurke L, Mattei A, Chaloupka K, Marx A, Sutter PM, Stierli P, Harder F, Heberer M: Mechanisms of ischemic preconditioning in skeletal muscle. J Surg Res. 2000, 94: 18-27. 10.1006\/jsre.2000.5987.","journal-title":"J Surg Res"},{"issue":"Suppl 2","key":"34_CR23","doi-asserted-by":"publisher","first-page":"P70","DOI":"10.1186\/cc6291","volume":"12","author":"A Sen","year":"2008","unstructured":"Sen A, Martin D, Grocott M, Montgomery H: Changes in thenar eminence tissue oxygen saturation measured using near-infrared spectroscopy suggest ischaemic preconditioning in a repeated arterial occlusion forearm ischaemia model. Critical Care. 2008, 12 (Suppl 2): P70-10.1186\/cc6291. (Abstract)","journal-title":"Critical Care"}],"container-title":["Journal of Trauma Management &amp; Outcomes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-2897-4-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-2897-4-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-2897-4-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-2897-4-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T04:21:09Z","timestamp":1630470069000},"score":1,"resource":{"primary":{"URL":"https:\/\/traumamanagement.biomedcentral.com\/articles\/10.1186\/1752-2897-4-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,13]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["34"],"URL":"https:\/\/doi.org\/10.1186\/1752-2897-4-5","relation":{},"ISSN":["1752-2897"],"issn-type":[{"value":"1752-2897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,13]]},"assertion":[{"value":"7 December 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"5"}}