{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:06:17Z","timestamp":1791324377425,"version":"4.3.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fibrogenesis Tissue Repair"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1755-1536-6-9","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:05:24Z","timestamp":1367453124000},"source":"Crossref","is-referenced-by-count":53,"title":["Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases"],"prefix":"10.1186","volume":"6","author":[{"given":"Federica","family":"Genovese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Barascuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R\u00f8ssel","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Nawrocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne Skovg\u00e5rd","family":"Veidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Julie","family":"Leeming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Asser","family":"Karsdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"125_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dmm.004077","volume":"4","author":"TR Cox","year":"2011","unstructured":"Cox TR, Erler JT: Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech. 2011, 4: 165-178.","journal-title":"Dis Model Mech"},{"issue":"2","key":"125_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1089\/adt.2012.474","volume":"11","author":"MA Karsdal","year":"2012","unstructured":"Karsdal MA, Nielsen MJ, Sand JM: Extracellular matrix remodeling: the common denominator in connective tissue diseases possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure. Assay Drug Dev Technol. 2012, 11 (2): 70-92.","journal-title":"Assay Drug Dev Technol"},{"key":"125_CR3","doi-asserted-by":"publisher","first-page":"18947","DOI":"10.1074\/jbc.M100625200","volume":"276","author":"C Wiberg","year":"2001","unstructured":"Wiberg C, Hedbom E, Khairullina A: Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix. J Biol Chem. 2001, 276: 18947-18952.","journal-title":"J Biol Chem"},{"key":"125_CR4","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1172\/JCI23755","volume":"115","author":"L Schaefer","year":"2005","unstructured":"Schaefer L, Babelova A, Kiss E: The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest. 2005, 115: 2223-2233.","journal-title":"J Clin Invest"},{"key":"125_CR5","doi-asserted-by":"publisher","first-page":"17365","DOI":"10.1074\/jbc.M110.192682","volume":"286","author":"A Melchior-Becker","year":"2011","unstructured":"Melchior-Becker A, Dai G, Ding Z: Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J Biol Chem. 2011, 286: 17365-17375.","journal-title":"J Biol Chem"},{"key":"125_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","volume":"10","author":"AM Gressner","year":"2006","unstructured":"Gressner AM, Weiskirchen R: Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med. 2006, 10: 76-99.","journal-title":"J Cell Mol Med"},{"key":"125_CR7","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.matbio.2006.04.004","volume":"25","author":"R Droguett","year":"2006","unstructured":"Droguett R, Cabello-Verrugio C, Riquelme C, Brandan E: Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation. Matrix Biol. 2006, 25: 332-341.","journal-title":"Matrix Biol"},{"issue":"1","key":"125_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3109\/03008207.2012.715700","volume":"54","author":"T Tang","year":"2012","unstructured":"Tang T, Thompson JC, Wilson PG: Decreased body fat, elevated plasma transforming growth factor-beta levels, and impaired BMP4-like signaling in biglycan-deficient mice. Connect Tissue Res. 2012, 54 (1): 5-13.","journal-title":"Connect Tissue Res"},{"key":"125_CR9","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1016\/j.transproceed.2008.09.033","volume":"40","author":"H KirimLioglu","year":"2008","unstructured":"KirimLioglu H, KirimLioglu V, Yilmaz S: Expression of matrix metalloproteinases 2 and 9 in donor liver, cirrhotic liver, and acute rejection after human liver transplantation. Transplant Proc. 2008, 40: 3574-3577.","journal-title":"Transplant Proc"},{"key":"125_CR10","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.4049\/jimmunol.0903008","volume":"184","author":"SK Madala","year":"2010","unstructured":"Madala SK, Pesce JT, Ramalingam TR: Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J Immunol. 2010, 184: 3955-3963.","journal-title":"J Immunol"},{"key":"125_CR11","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","volume":"46","author":"S Hemmann","year":"2007","unstructured":"Hemmann S, Graf J, Roderfeld M, Roeb E: Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol. 2007, 46: 955-975.","journal-title":"J Hepatol"},{"key":"125_CR12","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.joca.2006.01.016","volume":"14","author":"BC Sondergaard","year":"2006","unstructured":"Sondergaard BC, Henriksen K, Wulf H: Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthr Cartil. 2006, 14: 738-748.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"125_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1155\/2010\/548263","volume":"28","author":"SS Veidal","year":"2009","unstructured":"Veidal SS, Bay-Jensen AC, Tougas G, Karsdal MA, Vainer B: Serum markers of liver fibrosis: combining the BIPED classification and neo-epitope approach in the development of new biomarkers. Dis Markers. 2009, 28 (1): 15-28.","journal-title":"Dis Markers"},{"key":"125_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/13547500902777608","volume":"14","author":"MA Karsdal","year":"2009","unstructured":"Karsdal MA, Henriksen K, Leeming DJ: Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development. Biomarkers. 2009, 14: 181-202.","journal-title":"Biomarkers"},{"key":"125_CR15","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1111\/j.1478-3231.2010.02309.x","volume":"30","author":"SS Veidal","year":"2010","unstructured":"Veidal SS, Vassiliadis E, Barascuk N: Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis. Liver Int. 2010, 30: 1293-1304.","journal-title":"Liver Int"},{"key":"125_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.clinbiochem.2010.03.012","volume":"43","author":"N Barascuk","year":"2010","unstructured":"Barascuk N, Veidal SS, Larsen L: A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen. Clin Biochem. 2010, 43: 899-904.","journal-title":"Clin Biochem"},{"key":"125_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-5945-11-6","volume":"11","author":"E Vassiliadis","year":"2011","unstructured":"Vassiliadis E, Veidal SS, Barascuk N: Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis. BMC Dermatol. 2011, 11: 6.","journal-title":"BMC Dermatol"},{"key":"125_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1755-1536-4-22","volume":"4","author":"SS Veidal","year":"2011","unstructured":"Veidal SS, Karsdal MA, Nawrocki A: Assessment of proteolytic degradation of the basement membrane: a fragment of type IV collagen as a biochemical marker for liver fibrosis. Fibrogenesis Tissue Repair. 2011, 4: 22.","journal-title":"Fibrogenesis Tissue Repair"},{"key":"125_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.clinbiochem.2012.02.007","volume":"45","author":"SS Veidal","year":"2012","unstructured":"Veidal SS, Larsen DV, Chen X: MMP-mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis. Clin Biochem. 2012, 45: 541-546.","journal-title":"Clin Biochem"},{"key":"125_CR20","doi-asserted-by":"publisher","first-page":"e24753","DOI":"10.1371\/journal.pone.0024753","volume":"6","author":"SS Veidal","year":"2011","unstructured":"Veidal SS, Karsdal MA, Vassiliadis E: MMP mediated degradation of type VI collagen is highly associated with liver fibrosis\u2013identification and validation of a novel biochemical marker assay. PLoS One. 2011, 6: e24753.","journal-title":"PLoS One"},{"key":"125_CR21","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0344-0338(97)80052-0","volume":"193","author":"B Hogemann","year":"1997","unstructured":"Hogemann B, Edel G, Schwarz K, Krech R, Kresse H: Expression of biglycan, decorin and proteoglycan-100\/CSF-1 in normal and fibrotic human liver. Pathol Res Pract. 1997, 193: 747-751.","journal-title":"Pathol Res Pract"},{"key":"125_CR22","doi-asserted-by":"crossref","first-page":"L1327","DOI":"10.1152\/ajplung.2001.280.6.L1327","volume":"280","author":"M Kolb","year":"2001","unstructured":"Kolb M, Margetts PJ, Sime PJ, Gauldie J: Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol. 2001, 280: L1327-L1334.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"125_CR23","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1046\/j.1523-1755.2000.00868.x","volume":"57","author":"MB Stokes","year":"2000","unstructured":"Stokes MB, Holler S, Cui Y: Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease. Kidney Int. 2000, 57: 487-498.","journal-title":"Kidney Int"},{"key":"125_CR24","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.cardiores.2003.08.017","volume":"60","author":"MS Ahmed","year":"2003","unstructured":"Ahmed MS, Oie E, Vinge LE: Induction of myocardial biglycan in heart failure in rats\u2013an extracellular matrix component targeted by AT(1) receptor antagonism. Cardiovasc Res. 2003, 60: 557-568.","journal-title":"Cardiovasc Res"},{"key":"125_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/03008200802148504","volume":"49","author":"E Bereczki","year":"2008","unstructured":"Bereczki E, Santha M: The role of biglycan in the heart. Connect Tissue Res. 2008, 49: 129-132.","journal-title":"Connect Tissue Res"},{"issue":"12","key":"125_CR26","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1369\/0022155412456380","volume":"60","author":"MV Nastase","year":"2012","unstructured":"Nastase MV, Young MF, Schaefer L: Biglycan: a multivalent proteoglycan providing structure and signals. J Histochem Cytoche. 2012, 60 (12): 963-975.","journal-title":"J Histochem Cytoche"},{"key":"125_CR27","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1002\/art.22599","volume":"56","author":"MA Karsdal","year":"2007","unstructured":"Karsdal MA, Sumer EU, Wulf H: Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum. 2007, 56: 1549-1558.","journal-title":"Arthritis Rheum"},{"key":"125_CR28","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1186\/ar2434","volume":"10","author":"MA Karsdal","year":"2008","unstructured":"Karsdal MA, Madsen SH, Christiansen C: Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther. 2008, 10: R63.","journal-title":"Arthritis Res Ther"},{"key":"125_CR29","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/1479-5876-10-195","volume":"10","author":"AS Siebuhr","year":"2012","unstructured":"Siebuhr AS, Wang J, Karsdal MA, Bay-Jensen A: Matrix metalloproteinase-dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen-induced arthritis. J Transl Med. 2012, 10: 195.","journal-title":"J Transl Med"},{"key":"125_CR30","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/liv.12044","volume":"33","author":"DJ Leeming","year":"2013","unstructured":"Leeming DJ, Byrialsen I, Jim\u00e9nez W, Christiansen C, Karsdal MA: Protein fingerprinting of the extracellular matrix remodeling in a rat model of liver fibrosis - a serological evaluation. Liver Int. 2013, 33: 439-447.","journal-title":"Liver Int"},{"issue":"Suppl 1","key":"125_CR31","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","volume":"38","author":"SL Friedman","year":"2003","unstructured":"Friedman SL: Liver fibrosis \u2013 from bench to bedside. J Hepatol. 2003, 38 (Suppl 1): S38-S53.","journal-title":"J Hepatol"},{"key":"125_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1055\/s-2006-927387","volume":"45","author":"C Weiler-Normann","year":"2007","unstructured":"Weiler-Normann C, Herkel J, Lohse AW: Mouse models of liver fibrosis. Z Gastroenterol. 2007, 45: 43-50.","journal-title":"Z Gastroenterol"},{"key":"125_CR33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0968-0004(99)01540-6","volume":"25","author":"C Combet","year":"2000","unstructured":"Combet C, Blanchet C, Geourjon C, Deleage G: NPS@: network protein sequence analysis. Trends Biochem Sci. 2000, 25: 147-150.","journal-title":"Trends Biochem Sci"},{"key":"125_CR34","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1089\/adt.2005.3.553","volume":"3","author":"S Schaller","year":"2005","unstructured":"Schaller S, Henriksen K, Hoegh-Andersen P: In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?. Assay Drug Dev Technol. 2005, 3: 553-580.","journal-title":"Assay Drug Dev Technol"},{"key":"125_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1755-1536-4-19","volume":"4","author":"T Segovia-Silvestre","year":"2011","unstructured":"Segovia-Silvestre T, Reichenbach V, Fernandez-Varo G: Circulating CO3-610, a degradation product of collagen III, closely reflects liver collagen and portal pressure in rats with fibrosis. Fibrogenesis Tissue Repair. 2011, 4: 19.","journal-title":"Fibrogenesis Tissue Repair"},{"key":"125_CR36","first-page":"379","volume-title":"Ascites and Renal Dysfunction in Liver Disease. Pathogenesis Diagnosis and Treatment","author":"J Clari\u00e0","year":"2005","unstructured":"Clari\u00e0 J, Jimenez W: Renal dysfunction and ascites in carbon tetrachloride-induced cirrhosis in rats. Ascites and Renal Dysfunction in Liver Disease. Pathogenesis Diagnosis and Treatment . Edited by: Arroyo V, Gin\u00e8s P, Rod\u00e9s J, Schrier RW. 2005, Malden, MA: Blackwell Science Inc, 379-396."},{"key":"125_CR37","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1124\/jpet.107.131896","volume":"324","author":"J Munoz-Luque","year":"2008","unstructured":"Munoz-Luque J, Ros J, Fernandez-Varo G: Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. J Pharmacol Exp Ther. 2008, 324: 475-483.","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Fibrogenesis &amp; Tissue Repair"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1755-1536-6-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1755-1536-6-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1755-1536-6-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T02:57:22Z","timestamp":1548212242000},"score":1,"resource":{"primary":{"URL":"https:\/\/fibrogenesis.biomedcentral.com\/articles\/10.1186\/1755-1536-6-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["125"],"URL":"https:\/\/doi.org\/10.1186\/1755-1536-6-9","relation":{},"ISSN":["1755-1536"],"issn-type":[{"value":"1755-1536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,1]]},"article-number":"9"}}