{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:09:10Z","timestamp":1770822550481,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T00:00:00Z","timestamp":1289779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T00:00:00Z","timestamp":1289779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cytogenet"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Recent genome-wide microarray-based research investigations have revealed a high frequency of submicroscopic copy number alterations (CNAs) in the myelodysplastic syndromes (MDS), suggesting microarray-based comparative genomic hybridization (aCGH) has the potential to detect new clinically relevant genomic markers in a diagnostic laboratory.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We performed an exploratory study on 30 cases of MDS, myeloproliferative neoplasia (MPN) or evolving acute myeloid leukemia (AML) (% bone marrow blasts \u2264 30%, range 0-30%, median, 8%) by aCGH, using a genome-wide bacterial artificial chromosome (BAC) microarray. The sample data were compared to corresponding cytogenetics, fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH), and clinical-pathological findings. Previously unidentified imbalances, in particular those considered submicroscopic aberrations (&lt; 10 Mb), were confirmed by FISH analysis. CNAs identified by aCGH were concordant with the cytogenetic\/FISH results in 25\/30 (83%) of the samples tested. aCGH revealed new CNAs in 14\/30 (47%) patients, including 28 submicroscopic or hidden aberrations verified by FISH studies. Cryptic 344-kb <jats:italic>RUNX1<\/jats:italic> deletions were found in three patients at time of AML transformation. Other hidden CNAs involved 3q26.2\/EVI1, 5q22\/APC, 5q32\/TCERG1,12p13.1\/EMP1, 12q21.3\/KITLG, and 17q11.2\/NF1. Gains of CCND2\/12p13.32 were detected in two patients. aCGH failed to detect a balanced translocation (n = 1) and low-level clonality (n = 4) in five karyotypically aberrant samples, revealing clinically important assay limitations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The detection of previously known and unknown genomic alterations suggests that aCGH has considerable promise for identification of both recurring microscopic and submicroscopic genomic imbalances that contribute to myeloid disease pathogenesis and progression. These findings suggest that development of higher-resolution microarray platforms could improve karyotyping in clinical practice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1755-8166-3-23","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T07:16:12Z","timestamp":1289891772000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessing karyotype precision by microarray-based comparative genomic hybridization in the myelodysplastic\/myeloproliferative syndromes"],"prefix":"10.1186","volume":"3","author":[{"given":"Marilyn L","family":"Slovak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Bedell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hsuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Gaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blake C","family":"Ballif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa G","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"78_CR1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","volume":"114","author":"JW Vardiman","year":"2009","unstructured":"Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellstrom-Lindberg E, Tefferi A, Bloomfield CD: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009, 114: 937\u2013951. 10.1182\/blood-2009-03-209262","journal-title":"Blood"},{"key":"78_CR2","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1002\/cncr.22570","volume":"109","author":"X Ma","year":"2007","unstructured":"Ma X, Does M, Raza A, Mayne ST: Myelodysplastic syndromes: incidence and survival in the United States. Cancer 2007, 109: 1536\u20131542. 10.1002\/cncr.22570","journal-title":"Cancer"},{"key":"78_CR3","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1093\/jnci\/djn349","volume":"100","author":"MA Sekeres","year":"2008","unstructured":"Sekeres MA, Schoonen WM, Kantarjian H, List A, Fryzek J, Paquette R, Maciejewski JP: Characteristics of US patients with myelodysplastic syndromes: results of six cross-sectional physician surveys. J Natl Cancer Inst 2008, 100: 1542\u20131551. 10.1093\/jnci\/djn349","journal-title":"J Natl Cancer Inst"},{"key":"78_CR4","doi-asserted-by":"crossref","unstructured":"Hanson LC, Muss HB: Cancer in the oldest old: making better treatment decisions. J Clin Oncol 28: 1975\u20131976. 10.1200\/JCO.2009.27.6022","DOI":"10.1200\/JCO.2009.27.6022"},{"key":"78_CR5","doi-asserted-by":"publisher","first-page":"e1225","DOI":"10.1371\/journal.pone.0001225","volume":"2","author":"LP Gondek","year":"2007","unstructured":"Gondek LP, Dunbar AJ, Szpurka H, McDevitt MA, Maciejewski JP: SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS\/MPD-U and MPD. PLoS One 2007, 2: e1225. 10.1371\/journal.pone.0001225","journal-title":"PLoS One"},{"key":"78_CR6","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1182\/blood-2007-05-092304","volume":"111","author":"LP Gondek","year":"2008","unstructured":"Gondek LP, Tiu R, O'Keefe CL, Sekeres MA, Theil KS, Maciejewski JP: Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS\/MPD, and MDS-derived AML. Blood 2008, 111: 1534\u20131542. 10.1182\/blood-2007-05-092304","journal-title":"Blood"},{"key":"78_CR7","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1182\/blood-2008-02-130435","volume":"112","author":"JP Maciejewski","year":"2008","unstructured":"Maciejewski JP, Mufti GJ: Whole genome scanning as a cytogenetic tool in hematologic malignancies. Blood 2008, 112: 965\u2013974. 10.1182\/blood-2008-02-130435","journal-title":"Blood"},{"key":"78_CR8","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1182\/blood-2007-03-079673","volume":"110","author":"A Mohamedali","year":"2007","unstructured":"Mohamedali A, Gaken J, Twine NA, Ingram W, Westwood N, Lea NC, Hayden J, Donaldson N, Aul C, Gattermann N, Giagounidis A, Germing U, List AF, Mufti GJ: Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes. Blood 2007, 110: 3365\u20133373. 10.1182\/blood-2007-03-079673","journal-title":"Blood"},{"key":"78_CR9","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","volume":"89","author":"P Greenberg","year":"1997","unstructured":"Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J: International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997, 89: 2079\u20132088.","journal-title":"Blood"},{"key":"78_CR10","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1182\/blood-2007-03-082404","volume":"110","author":"D Haase","year":"2007","unstructured":"Haase D, Germing U, Schanz J, Pfeilstocker M, Nosslinger T, Hildebrandt B, Kundgen A, Lubbert M, Kunzmann R, Giagounidis AA, Aul C, Trumper L, Krieger O, Stauder R, Muller TH, Wimazal F, Valent P, Fonatsch C, Steidl C: New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood 2007, 110: 4385\u20134395. 10.1182\/blood-2007-03-082404","journal-title":"Blood"},{"key":"78_CR11","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1056\/NEJMoa061292","volume":"355","author":"A List","year":"2006","unstructured":"List A, Dewald G, Bennett J, Giagounidis A, Raza A, Feldman E, Powell B, Greenberg P, Thomas D, Stone R, Reeder C, Wride K, Patin J, Schmidt M, Zeldis J, Knight R: Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006, 355: 1456\u20131465. 10.1056\/NEJMoa061292","journal-title":"N Engl J Med"},{"key":"78_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00277-005-1054-0","volume":"84","author":"AA Giagounidis","year":"2005","unstructured":"Giagounidis AA, Germing U, Strupp C, Hildebrandt B, Heinsch M, Aul C: Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup. Ann Hematol 2005, 84: 569\u2013571. 10.1007\/s00277-005-1054-0","journal-title":"Ann Hematol"},{"key":"78_CR13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1046\/j.1365-2141.2001.02933.x","volume":"114","author":"M Lubbert","year":"2001","unstructured":"Lubbert M, Wijermans P, Kunzmann R, Verhoef G, Bosly A, Ravoet C, Andre M, Ferrant A: Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2'-deoxycytidine. Br J Haematol 2001, 114: 349\u2013357. 10.1046\/j.1365-2141.2001.02933.x","journal-title":"Br J Haematol"},{"key":"78_CR14","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1038\/sj.leu.2404796","volume":"21","author":"K Raj","year":"2007","unstructured":"Raj K, John A, Ho A, Chronis C, Khan S, Samuel J, Pomplun S, Thomas NS, Mufti GJ: CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 2007, 21: 1937\u20131944. 10.1038\/sj.leu.2404796","journal-title":"Leukemia"},{"key":"78_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.exphem.2008.10.012","volume":"37","author":"D Nowak","year":"2009","unstructured":"Nowak D, Nolte F, Mossner M, Nowak V, Baldus CD, Hopfer O, Noll S, Thiel E, Wagner F, Hofmann WK: Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomy. Exp Hematol 2009, 37: 215\u2013224. 10.1016\/j.exphem.2008.10.012","journal-title":"Exp Hematol"},{"key":"78_CR16","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/sj.leu.2404145","volume":"20","author":"K Paulsson","year":"2006","unstructured":"Paulsson K, Heidenblad M, Strombeck B, Staaf J, Jonsson G, Borg A, Fioretos T, Johansson B: High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration. Leukemia 2006, 20: 840\u2013846. 10.1038\/sj.leu.2404145","journal-title":"Leukemia"},{"key":"78_CR17","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/gcc.20498","volume":"46","author":"C Evers","year":"2007","unstructured":"Evers C, Beier M, Poelitz A, Hildebrandt B, Servan K, Drechsler M, Germing U, Royer HD, Royer-Pokora B: Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGH. Genes Chromosomes Cancer 2007, 46: 1119\u20131128. 10.1002\/gcc.20498","journal-title":"Genes Chromosomes Cancer"},{"key":"78_CR18","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1182\/blood-2007-11-122028","volume":"112","author":"DT Starczynowski","year":"2008","unstructured":"Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A: High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood 2008, 112: 3412\u20133424. 10.1182\/blood-2007-11-122028","journal-title":"Blood"},{"key":"78_CR19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3324\/haematol.13024","volume":"94","author":"T Akagi","year":"2009","unstructured":"Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C, Koeffler HP: Frequent genomic abnormalities in acute myeloid leukemia\/myelodysplastic syndrome with normal karyotype. Haematologica 2009, 94: 213\u2013223. 10.3324\/haematol.13024","journal-title":"Haematologica"},{"key":"78_CR20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","volume":"51","author":"JM Bennett","year":"1982","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C: Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982, 51: 189\u2013199.","journal-title":"Br J Haematol"},{"key":"78_CR21","series-title":"Lyon: IARC","first-page":"87","volume-title":"The Myelodysplastic Syndromes\/Neoplasms In World Health Organization of Tumors of Haematopoietic and Lymphoid Tissues","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds): The Myelodysplastic Syndromes\/Neoplasms In World Health Organization of Tumors of Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2008:87\u2013104."},{"key":"78_CR22","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1182\/blood.V68.3.790.790","volume":"68","author":"J Michaeli","year":"1986","unstructured":"Michaeli J, Lerer I, Rachmilewitz EA, Fibach E: Stimulation of proliferation of human myeloid leukemia cells in culture: applications for cytogenetic analysis. Blood 1986, 68: 790\u2013793.","journal-title":"Blood"},{"key":"78_CR23","volume-title":"ISCN (2009): An International System for Human Cytogenetic Nomenclature","year":"2009","unstructured":"Shaffer LG, Slovak ML, Campbell LJ, (Eds): ISCN (2009): An International System for Human Cytogenetic Nomenclature. Basel: S. Karger; 2009."},{"key":"78_CR24","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1365-2141.2007.06505.x","volume":"136","author":"D Bobadilla","year":"2007","unstructured":"Bobadilla D, Enriquez EL, Alvarez G, Gaytan P, Smith D, Slovak ML: An interphase fluorescence in situ hybridisation assay for the detection of 3q26.2\/EVI1 rearrangements in myeloid malignancies. Br J Haematol 2007, 136: 806\u2013813. 10.1111\/j.1365-2141.2007.06505.x","journal-title":"Br J Haematol"},{"key":"78_CR25","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1755-8166-1-8","volume":"1","author":"BC Ballif","year":"2008","unstructured":"Ballif BC, Theisen A, Coppinger J, Gowans GC, Hersh JH, Madan-Khetarpal S, Schmidt KR, Tervo R, Escobar LF, Friedrich CA, McDonald M, Campbell L, Ming JE, Zackai EH, Bejjani BA, Shaffer LG: Expanding the clinical phenotype of the 3q29 microdeletion syndrome and characterization of the reciprocal microduplication. Mol Cytogenet 2008, 1: 8. 10.1186\/1755-8166-1-8","journal-title":"Mol Cytogenet"},{"key":"78_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cancergencyto.2005.01.006","volume":"158","author":"ML Slovak","year":"2005","unstructured":"Slovak ML, Bedell V, Pagel K, Chang KL, Smith D, Somlo G: Targeting plasma cells improves detection of cytogenetic aberrations in multiple myeloma: phenotype\/genotype fluorescence in situ hybridization. Cancer Genet Cytogenet 2005, 158: 99\u2013109. 10.1016\/j.cancergencyto.2005.01.006","journal-title":"Cancer Genet Cytogenet"},{"key":"78_CR27","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1365-2141.2009.07757.x","volume":"146","author":"JP Maciejewski","year":"2009","unstructured":"Maciejewski JP, Tiu RV, O'Keefe C: Application of array-based whole genome scanning technologies as a cytogenetic tool in haematological malignancies. Br J Haematol 2009, 146: 479\u2013488. 10.1111\/j.1365-2141.2009.07757.x","journal-title":"Br J Haematol"},{"key":"78_CR28","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3324\/haematol.12603","volume":"93","author":"L Wang","year":"2008","unstructured":"Wang L, Fidler C, Nadig N, Giagounidis A, Della Porta MG, Malcovati L, Killick S, Gattermann N, Aul C, Boultwood J, Wainscoat JS: Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays. Haematologica 2008, 93: 994\u20131000. 10.3324\/haematol.12603","journal-title":"Haematologica"},{"key":"78_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1365-2141.2008.07178.x","volume":"142","author":"A Pellagatti","year":"2008","unstructured":"Pellagatti A, Hellstrom-Lindberg E, Giagounidis A, Perry J, Malcovati L, Della Porta MG, Jadersten M, Killick S, Fidler C, Cazzola M, Wainscoat JS, Boultwood J: Haploinsufficiency of RPS14 in 5q-syndrome is associated with deregulation of ribosomal- and translation-related genes. Br J Haematol 2008, 142: 57\u201364. 10.1111\/j.1365-2141.2008.07178.x","journal-title":"Br J Haematol"},{"key":"78_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nature06494","volume":"451","author":"BL Ebert","year":"2008","unstructured":"Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, Raza A, Root DE, Attar E, Ellis SR, Golub TR: Identification of RPS14 as a 5q-syndrome gene by RNA interference screen. Nature 2008, 451: 335\u2013339. 10.1038\/nature06494","journal-title":"Nature"},{"key":"78_CR31","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1182\/blood-2008-05-159707","volume":"112","author":"A Valencia","year":"2008","unstructured":"Valencia A, Cervera J, Such E, Sanz MA, Sanz GF: Lack of RPS14 promoter aberrant methylation supports the haploinsufficiency model for the 5q-syndrome. Blood 2008, 112: 918. 10.1182\/blood-2008-05-159707","journal-title":"Blood"},{"key":"78_CR32","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1046\/j.1365-2141.2003.04713.x","volume":"123","author":"B Stewart","year":"2003","unstructured":"Stewart B, Verdugo M, Guthrie KA, Appelbaum F, Deeg HJ: Outcome following haematopoietic cell transplantation in patients with myelodysplasia and del (5q) karyotypes. Br J Haematol 2003, 123: 879\u2013885. 10.1046\/j.1365-2141.2003.04713.x","journal-title":"Br J Haematol"},{"key":"78_CR33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/(SICI)1098-2264(199706)19:2<77::AID-GCC2>3.0.CO;2-X","volume":"19","author":"P Andreasson","year":"1997","unstructured":"Andreasson P, Johansson B, Arheden K, Billstrom R, Mitelman F, Hoglund M: Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. Genes Chromosomes Cancer 1997, 19: 77\u201383. 10.1002\/(SICI)1098-2264(199706)19:2<77::AID-GCC2>3.0.CO;2-X","journal-title":"Genes Chromosomes Cancer"},{"key":"78_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1046\/j.1365-2141.1997.2643079.x","volume":"98","author":"F Ohtsuki","year":"1997","unstructured":"Ohtsuki F, Yamamoto M, Nakagawa T, Tanizawa T, Wada H: Granulocyte-macrophage colony-stimulating factor abrogates transforming growth factor-beta 1-mediated cell cycle arrest by up-regulating cyclin D2\/Cdk6. Br J Haematol 1997, 98: 520\u2013527. 10.1046\/j.1365-2141.1997.2643079.x","journal-title":"Br J Haematol"},{"key":"78_CR35","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.cancergencyto.2009.04.013","volume":"193","author":"ML Slovak","year":"2009","unstructured":"Slovak ML, O'Donnell M, Smith DD, Gaal K: Does MDS with der(1;7)(q10;p10) constitute a distinct risk group? A retrospective single institutional analysis of clinical\/pathologic features compared to -7\/del(7q) MDS. Cancer Genet Cytogenet 2009, 193: 78\u201385. 10.1016\/j.cancergencyto.2009.04.013","journal-title":"Cancer Genet Cytogenet"},{"key":"78_CR36","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/sj.leu.2404619","volume":"21","author":"M Sanada","year":"2007","unstructured":"Sanada M, Uike N, Ohyashiki K, Ozawa K, Lili W, Hangaishi A, Kanda Y, Chiba S, Kurokawa M, Omine M, Mitani K, Ogawa S: Unbalanced translocation der(1;7)(q10;p10) defines a unique clinicopathological subgroup of myeloid neoplasms. Leukemia 2007, 21: 992\u2013997.","journal-title":"Leukemia"},{"key":"78_CR37","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/sj.leu.2405078","volume":"22","author":"J Pedersen-Bjergaard","year":"2008","unstructured":"Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH: Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia 2008, 22: 240\u2013248. 10.1038\/sj.leu.2405078","journal-title":"Leukemia"},{"key":"78_CR38","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/sj.leu.2404136","volume":"20","author":"H Niimi","year":"2006","unstructured":"Niimi H, Harada H, Harada Y, Ding Y, Imagawa J, Inaba T, Kyo T, Kimura A: Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1\/RUNX1 point mutations. Leukemia 2006, 20: 635\u2013644. 10.1038\/sj.leu.2404136","journal-title":"Leukemia"},{"key":"78_CR39","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1186\/1471-2407-8-299","volume":"8","author":"V Gelsi-Boyer","year":"2008","unstructured":"Gelsi-Boyer V, Trouplin V, Adelaide J, Aceto N, Remy V, Pinson S, Houdayer C, Arnoulet C, Sainty D, Bentires-Alj M, Olschwang S, Vey N, Mozziconacci MJ, Birnbaum D, Chaffanet M: Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. BMC Cancer 2008, 8: 299. 10.1186\/1471-2407-8-299","journal-title":"BMC Cancer"},{"key":"78_CR40","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1158\/1078-0432.CCR-09-2639","volume":"16","author":"B Parkin","year":"2010","unstructured":"Parkin B, Ouillette P, Wang Y, Liu Y, Wright W, Roulston D, Purkayastha A, Dressel A, Karp J, Bockenstedt P, Al-Zoubi A, Talpaz M, Kujawski L, Shedden K, Shakhan S, Li C, Erba H, Malek SN: NF1 Inactivation in Adult Acute Myelogenous Leukemia. Clin Cancer Res 2010, 16: 4135\u20134147. 10.1158\/1078-0432.CCR-09-2639","journal-title":"Clin Cancer Res"},{"key":"78_CR41","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1182\/blood-2007-10-119230","volume":"111","author":"S Lugthart","year":"2008","unstructured":"Lugthart S, van Drunen E, van Norden Y, van Hoven A, Erpelinck CA, Valk PJ, Beverloo HB, Lowenberg B, Delwel R: High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 2008, 111: 4329\u20134337. 10.1182\/blood-2007-10-119230","journal-title":"Blood"},{"key":"78_CR42","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1200\/JCO.2009.26.0646","volume":"28","author":"S Groschel","year":"2010","unstructured":"Groschel S, Lugthart S, Schlenk RF, Valk PJ, Eiwen K, Goudswaard C, van Putten WJ, Kayser S, Verdonck LF, Lubbert M, Ossenkoppele GJ, Germing U, Schmidt-Wolf I, Schlegelberger B, Krauter J, Ganser A, Dohner H, Lowenberg B, Dohner K, Delwel R: High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities. J Clin Oncol 2010, 28: 2101\u20132107. 10.1200\/JCO.2009.26.0646","journal-title":"J Clin Oncol"},{"key":"78_CR43","volume-title":"American Society of Hematology Annual Meeting. Atlanta, GA","author":"HA Greisman","year":"2007","unstructured":"Greisman HA, Yi HS, Hoffman NG: transCGH: rapid identification and high-resolution mapping of balanced IgH translocations in archival DNA using custom oligonucleotide arrays. American Society of Hematology Annual Meeting. Atlanta, GA 2007."},{"key":"78_CR44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2156-9-2","volume":"9","author":"NJ Wang","year":"2008","unstructured":"Wang NJ, Parokonny AS, Thatcher KN, Driscoll J, Malone BM, Dorrani N, Sigman M, LaSalle JM, Schanen NC: Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. BMC Genet 2008, 9: 2. 10.1186\/1471-2156-9-2","journal-title":"BMC Genet"},{"key":"78_CR45","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/j.1365-2141.2009.07697.x","volume":"145","author":"V Gelsi-Boyer","year":"2009","unstructured":"Gelsi-Boyer V, Trouplin V, Adelaide J, Bonansea J, Cervera N, Carbuccia N, Lagarde A, Prebet T, Nezri M, Sainty D, Olschwang S, Xerri L, Chaffanet M, Mozziconacci MJ, Vey N, Birnbaum D: Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 2009, 145: 788\u2013800. 10.1111\/j.1365-2141.2009.07697.x","journal-title":"Br J Haematol"},{"key":"78_CR46","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","volume":"360","author":"F Delhommeau","year":"2009","unstructured":"Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, Kosmider O, Le Couedic JP, Robert F, Alberdi A, Lecluse Y, Plo I, Dreyfus FJ, Marzac C, Casadevall N, Lacombe C, Romana SP, Dessen P, Soulier J, Viguie F, Fontenay M, Vainchenker W, Bernard OA: Mutation in TET2 in myeloid cancers. N Engl J Med 2009, 360: 2289\u20132301. 10.1056\/NEJMoa0810069","journal-title":"N Engl J Med"},{"key":"78_CR47","doi-asserted-by":"publisher","first-page":"7518","DOI":"10.1158\/0008-5472.CAN-09-1428","volume":"69","author":"DP Steensma","year":"2009","unstructured":"Steensma DP, Neiger JD, Porcher JC, Keats JJ, Bergsagel PL, Dennis TR, Knudson RA, Jenkins RB, Santana-Davila R, Kumar R, Ketterling RP: Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes. Cancer Res 2009, 69: 7518\u20137523. 10.1158\/0008-5472.CAN-09-1428","journal-title":"Cancer Res"},{"key":"78_CR48","doi-asserted-by":"publisher","first-page":"10349","DOI":"10.1158\/0008-5472.CAN-08-2754","volume":"68","author":"AJ Dunbar","year":"2008","unstructured":"Dunbar AJ, Gondek LP, O'Keefe CL, Makishima H, Rataul MS, Szpurka H, Sekeres MA, Wang XF, McDevitt MA, Maciejewski JP: 250 K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res 2008, 68: 10349\u201310357. 10.1158\/0008-5472.CAN-08-2754","journal-title":"Cancer Res"}],"container-title":["Molecular Cytogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1755-8166-3-23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1755-8166-3-23\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1755-8166-3-23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T04:23:34Z","timestamp":1630470214000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularcytogenetics.biomedcentral.com\/articles\/10.1186\/1755-8166-3-23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,15]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["78"],"URL":"https:\/\/doi.org\/10.1186\/1755-8166-3-23","relation":{},"ISSN":["1755-8166"],"issn-type":[{"value":"1755-8166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,15]]},"assertion":[{"value":"7 October 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"23"}}