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A clinically distinct phenotype is usually observed in these cases, and no clear genotype-phenotype correlation is proposed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Here we present a case study of a 5-year-old girl with <jats:italic>de novo<\/jats:italic> submicroscopic deletion of chromosome 11q22.3 with mild mental retardation and facial dysmorphism. A standard cytogenetic analysis did not reveal any structural aberrations. In contrary, array-CGH analysis indicated a small deletion of 11q22.3.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>To our knowledge, this is the smallest 11q22.3 deletion reported in literature, containing nine RefSeq genes. Although none of the deleted genes are obvious candidates for the features observed in our patient, genes <jats:italic>CUL5<\/jats:italic> and <jats:italic>SLN<\/jats:italic> could play a key role in the features described.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1755-8166-4-17","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T06:28:26Z","timestamp":1314080906000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Submicroscopic interstitial deletion of chromosome 11q22.3 in a girl with mild mental retardation and facial dysmorphism: Case report"],"prefix":"10.1186","volume":"4","author":[{"given":"Danijela","family":"Krgovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Marcun Varda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja","family":"Zagorac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Kokalj-Vokac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,22]]},"reference":[{"issue":"3B","key":"96_CR1","first-page":"295","volume":"18","author":"E McPherson","year":"1982","unstructured":"McPherson E, Meissner L: 11q-syndrome: review and report of two cases. 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