{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:30:21Z","timestamp":1790173821299,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cytogenet"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chromosomal translocation (11;14)(q13;q32) rearranging the locus for cyclin D1 (<jats:italic>CCND1<\/jats:italic>) to that of the immunoglobulin heavy chain (<jats:italic>IGH<\/jats:italic>) can be found in virtually all cases of mantle cell lymphoma (MCL), while other<jats:italic>CCND1<\/jats:italic>translocations are extremely rare. As<jats:italic>CCND1<\/jats:italic>overexpression and activation is a hallmark of MCL it is regarded as a central biological mechanism in the development and maintenance of this disease.<\/jats:p><jats:p>Here we present a patient initially diagnosed with chronic lymphocytic leukemia (CLL) where chromosome banding analysis revealed, among other aberrations, a translocation (11;22)(q13;q11.2). We show by fluorescence in situ hybridization (FISH) analysis that on chromosome 22 the immunoglobulin light chain lambda (<jats:italic>IGL<\/jats:italic>) is involved in this cytogenetic aberration. Additionally, we demonstrate the resulting overexpression of<jats:italic>CCND1<\/jats:italic>on the RNA and protein level, thereby consolidating the new diagnosis of a MCL-like B-cell neoplasia. Summing up, we described a rare case of t(11;22)(q13;q11.2) in a MCL-like neoplasia and showed that this aberration leads to an overexpression of<jats:italic>CCND1<\/jats:italic>which is regarded as a key biological feature in MCL. This case underlines the importance of cytogenetic analyses especially in atypical cases of B cell lymphomas.<\/jats:p>","DOI":"10.1186\/1755-8166-4-8","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T19:07:40Z","timestamp":1302116860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting in a fusion of IGL and CCND1: case report"],"prefix":"10.1186","volume":"4","author":[{"given":"Cristiano","family":"Krings Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inka","family":"Praulich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Gehrke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Anton","family":"Kreuzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"87_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1182\/blood-2005-06-2508","volume":"107","author":"LM Morton","year":"2006","unstructured":"Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS: Lymphoma incidence patterns by WHO subtype in the United States, 1992\u20132001. 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