{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:39:28Z","timestamp":1791250768830,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T00:00:00Z","timestamp":1319500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1755-8794-4-74","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T07:19:38Z","timestamp":1321600778000},"source":"Crossref","is-referenced-by-count":34,"title":["Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway"],"prefix":"10.1186","volume":"4","author":[{"given":"Jean-Luc C","family":"Mougeot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred A","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,25]]},"reference":[{"issue":"3","key":"271_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/17482961003602363","volume":"11","author":"A Bodansky","year":"2010","unstructured":"Bodansky A, Kim JM, Tempest L, Velagapudi A, Libby R, Ravits J: TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread. Amyotroph Lateral Scler. 2010, 11 (3): 321-327. 10.3109\/17482961003602363.","journal-title":"Amyotroph Lateral Scler"},{"issue":"10","key":"271_CR2","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ng.442","volume":"41","author":"MA van Es","year":"2009","unstructured":"van Es MA, Veldink JH, Saris CG, Blauw HM, van Vught PW, Birve A, Lemmens R, Schelhaas HJ, Groen EJ, Huisman MH, van der Kooi AJ, de Visser M, Dahlberg C, Estrada K, Rivadeneira F, Hofman A, Zwarts MJ, van Doormaal PT, Rujescu D, Strengman E, Giegling I, Muglia P, Tomik B, Slowik A, Uitterlinden AG, Hendrich C, Waibel S, Meyer T, Ludolph AC, Glass JD, et al: Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet. 2009, 41 (10): 1083-1087. 10.1038\/ng.442.","journal-title":"Nat Genet"},{"issue":"10","key":"271_CR3","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1474-4422(07)70222-3","volume":"6","author":"MA van Es","year":"2007","unstructured":"van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Andersen PM, van den Bosch L, de Jong SW, van't Slot R, Birve A, Lemmens R, de Jong V, Baas F, Schelhaas HJ, Sleegers K, van Broeckhoven C, Wokke JH, Wijmenga C, Robberecht W, Veldink JH, Ophoff RA, van den Berg LH: ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurol. 2007, 6 (10): 869-77. 10.1016\/S1474-4422(07)70222-3.","journal-title":"Lancet Neurol"},{"issue":"5-6","key":"271_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3109\/17482960802673042","volume":"10","author":"MA van Es","year":"2009","unstructured":"van Es MA, van Vught PW, Veldink JH, Andersen PM, Birve A, Lemmens R, Cronin S, van der Kooi AJ, de Visser M, Schelhaas HJ, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke JH, Ophoff RA, van den Berg LH: Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009, 10 (5-6): 441-7. 10.3109\/17482960802673042.","journal-title":"Amyotroph Lateral Scler"},{"issue":"1","key":"271_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ng.2007.52","volume":"40","author":"MA van Es","year":"2008","unstructured":"van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, van den Bosch L, de Jong SW, de Jong V, Baas F, van't Slot R, Lemmens R, Schelhaas HJ, Birve A, Sleegers K, van Broeckhoven C, Schymick JC, Traynor BJ, Wokke JH, Wijmenga C, Robberecht W, Andersen PM, Veldink JH, Ophoff RA, van den Berg LH: Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat Genet. 2008, 40 (1): 29-31. 10.1038\/ng.2007.52.","journal-title":"Nat Genet"},{"issue":"4","key":"271_CR6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1001\/archneurol.2010.46","volume":"67","author":"H Daoud","year":"2010","unstructured":"Daoud H, Belzil V, Desjarlais A, Camu W, Dion PA, Rouleau GA: Analysis of the UNC13A gene as a risk factor for sporadic amyotrophic lateral sclerosis. Arch Neurol. 2010, 67 (4): 516-7.","journal-title":"Arch Neurol"},{"issue":"10","key":"271_CR7","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/S1474-4422(10)70197-6","volume":"9","author":"A Shatunov","year":"2010","unstructured":"Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, van Damme P, Hardiman O, Farmer AE, Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chi\u00f2 A, Traynor BJ, Melki J, Meininger V, Landers JE, McGuffin P, Glass JD, Pall H, Leigh PN, Hardy J, et al: Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol. 2010, 9 (10): 986-94. 10.1016\/S1474-4422(10)70197-6.","journal-title":"Lancet Neurol"},{"key":"271_CR8","unstructured":"The Euro-MOTOR project. [ http:\/\/www.euromotorproject.eu ]"},{"issue":"16","key":"271_CR9","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1093\/hmg\/ddq232","volume":"19","author":"LC Kudo","year":"2010","unstructured":"Kudo LC, Parfenova L, Vi N, Lau K, Pomakian J, Valdmanis P, Rouleau GA, Vinters HV, Wiedau-Pazos M, Karsten SL: Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis. Hum Mol Genet. 2010, 19 (16): 3233-3253. 10.1093\/hmg\/ddq232.","journal-title":"Hum Mol Genet"},{"issue":"5","key":"271_CR10","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s00415-009-5015-8","volume":"256","author":"J Lin","year":"2009","unstructured":"Lin J, Diamanduros A, Chowdhury SA, Scelsa S, Latov N, Sadiq SA: Specific electron transport chain abnormalities in amyotrophic lateral sclerosis. J Neurol. 2009, 256 (5): 774-782. 10.1007\/s00415-009-5015-8.","journal-title":"J Neurol"},{"key":"271_CR11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/1471-2164-10-405","volume":"10","author":"CG Saris","year":"2009","unstructured":"Saris CG, Horvath S, van Vught PW, van Es MA, Blauw HM, Fuller TF, Langfelder P, DeYoung J, Wokke JH, Veldink JH, van den Berg LH, Ophoff RA: Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. BMC Genomics. 2009, 10: 405-10.1186\/1471-2164-10-405.","journal-title":"BMC Genomics"},{"issue":"2","key":"271_CR12","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.nbd.2010.04.008","volume":"39","author":"S Gagliardi","year":"2010","unstructured":"Gagliardi S, Cova E, Davin A, Guareschi S, Abel K, Alvisi E, Laforenza U, Ghidoni R, Cashman JR, Ceroni M, Cereda C: SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis. Neurobiol Dis. 2010, 39 (2): 198-203. 10.1016\/j.nbd.2010.04.008.","journal-title":"Neurobiol Dis"},{"issue":"1-2","key":"271_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jneuroim.2010.08.012","volume":"230","author":"R Zhang","year":"2010","unstructured":"Zhang R, Hadlock KG, Do H, Yu S, Honrada R, Champion S, Forshew D, Madison C, Katz J, Miller RG, McGrath MS: Gene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol. 2010, 230 (1-2): 114-123.","journal-title":"J Neuroimmunol"},{"issue":"5","key":"271_CR14","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/ng.557","volume":"42","author":"JM Lincecum","year":"2010","unstructured":"Lincecum JM, Vieira FG, Wang MZ, Thompson K, De Zutter GS, Kidd J, Moreno A, Sanchez R, Carrion IJ, Levine BA, Al-Nakhala BM, Sullivan SM, Gill A, Perrin S: From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. Nat Genet. 2010, 42 (5): 392-9. 10.1038\/ng.557.","journal-title":"Nat Genet"},{"issue":"6","key":"271_CR15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/17482960802160990","volume":"9","author":"S Garbuzova-Davis","year":"2008","unstructured":"Garbuzova-Davis S, Saporta S, Sanberg PR: Implications of blood-brain barrier disruption in ALS. Amyotroph Lateral Scler. 2008, 9 (6): 375-376. 10.1080\/17482960802160990.","journal-title":"Amyotroph Lateral Scler"},{"key":"271_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1471-2164-7-115","volume":"7","author":"C Palmer","year":"2006","unstructured":"Palmer C, Diehn M, Alizadeh AA, Brown PO: Cell-type specific gene expression profiles of leukocytes in human peripheral blood. BMC Genomics. 2006, 7: 115-10.1186\/1471-2164-7-115.","journal-title":"BMC Genomics"},{"key":"271_CR17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1471-2164-11-96","volume":"11","author":"JL Min","year":"2010","unstructured":"Min JL, Barrett A, Watts T, Pettersson FH, Lockstone HE, Lindgren CM, Taylor JM, Allen M, Zondervan KT, McCarthy MI: Variability of gene expression profiles in human blood and lymphoblastoid cell lines. BMC Genomics. 2010, 11: 96-10.1186\/1471-2164-11-96.","journal-title":"BMC Genomics"},{"issue":"6","key":"271_CR18","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1089\/106652703322756131","volume":"10","author":"MK Kerr","year":"2003","unstructured":"Kerr MK: Linear models for microarray data analysis: hidden similarities and differences. J Comput Biol. 2003, 10 (6): 891-901. 10.1089\/106652703322756131.","journal-title":"J Comput Biol"},{"issue":"9","key":"271_CR19","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.1073\/pnas.091062498","volume":"98","author":"VG Tusher","year":"2001","unstructured":"Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001, 98 (9): 5116-5121. 10.1073\/pnas.091062498.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"271_CR20","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1093\/bioinformatics\/bti260","volume":"21","author":"WT Barry","year":"2005","unstructured":"Barry WT, Nobel AB, Wright FA: Significance analysis of functional categories in gene expression studies: a structured permutation approach. Bioinformatics. 2005, 21 (9): 1943-1949. 10.1093\/bioinformatics\/bti260.","journal-title":"Bioinformatics"},{"issue":"5","key":"271_CR21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL: El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000, 1 (5): 293-299. 10.1080\/146608200300079536.","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"1-2","key":"271_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0022-1759(03)00231-X","volume":"278","author":"U Repnik","year":"2003","unstructured":"Repnik U, Knezevic M, Jeras M: Simple and cost-effective isolation of monocytes from buffy coats. J Immunol Methods. 2003, 278 (1-2): 283-292. 10.1016\/S0022-1759(03)00231-X.","journal-title":"J Immunol Methods"},{"issue":"3","key":"271_CR23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/cfg.464","volume":"6","author":"GJ Rosa","year":"2005","unstructured":"Rosa GJ, Steibel JP, Tempelman RJ: Reassessing design and analysis of two-colour microarray experiments using mixed effects models. Comp Funct Genomics. 2005, 6 (3): 123-131. 10.1002\/cfg.464.","journal-title":"Comp Funct Genomics"},{"key":"271_CR24","unstructured":"The NCBI Gene Expression Omnibus database. [ http:\/\/www.ncbi.nlm.nih.gov\/geo ]"},{"key":"271_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/1471-2105-7-215","volume":"7","author":"AA Sioson","year":"2006","unstructured":"Sioson AA, Mane SP, Li P, Sha W, Heath LS, Bohnert HJ, Grene R: The statistics of identifying differentially expressed genes in Expresso and TM4: a comparison. BMC Bioinformatics. 2006, 7: 215-10.1186\/1471-2105-7-215.","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"271_CR26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/ana.20631","volume":"58","author":"C M\u00fcnch","year":"2005","unstructured":"M\u00fcnch C, Rosenbohm A, Sperfeld AD, Uttner I, Reske S, Krause BJ, Sedlmeier R, Meyer T, Hanemann CO, Stumm G, Ludolph AC: Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD. Ann Neurol. 2005, 58 (5): 777-80. 10.1002\/ana.20631.","journal-title":"Ann Neurol"},{"issue":"5","key":"271_CR27","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/ng.132","volume":"40","author":"E Kabashi","year":"2008","unstructured":"Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Vande Velde C, Bouchard JP, Lacomblez L, Pochigaeva K, Salachas F, Pradat PF, Camu W, Meininger V, Dupre N, Rouleau GA: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet. 2008, 40 (5): 572-4. 10.1038\/ng.132.","journal-title":"Nat Genet"},{"issue":"10","key":"271_CR28","doi-asserted-by":"publisher","first-page":"e13250","DOI":"10.1371\/journal.pone.0013250","volume":"5","author":"L Liu-Yesucevitz","year":"2010","unstructured":"Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B: Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010, 5 (10): e13250-10.1371\/journal.pone.0013250.","journal-title":"PLoS One"},{"issue":"8","key":"271_CR29","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1093\/nar\/gkm082","volume":"35","author":"G Schilders","year":"2007","unstructured":"Schilders G, van Dijk E, Pruijn GJ: C1D and hMtr4p associate with the human exosome subunit PM\/Scl-100 and are involved in pre-rRNA processing. Nucleic Acids Res. 2007, 35 (8): 2564-2572. 10.1093\/nar\/gkm082.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"271_CR30","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1017\/S1355838202021088","volume":"8","author":"MS Jurica","year":"2002","unstructured":"Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA. 2002, 8 (4): 426-439. 10.1017\/S1355838202021088.","journal-title":"RNA"},{"key":"271_CR31","doi-asserted-by":"publisher","first-page":"837474","DOI":"10.1155\/2011\/837474","volume":"2011","author":"H Kovar","year":"2011","unstructured":"Kovar H: Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS\/EWS\/TAF15 Protein Family. Sarcoma. 2011, 2011: 837474.","journal-title":"Sarcoma"},{"issue":"1","key":"271_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/mus.21428","volume":"41","author":"SJ Kolb","year":"2010","unstructured":"Kolb SJ, Sutton S, Schoenberg DR: RNA processing defects associated with diseases of the motor neuron. Muscle Nerve. 2010, 41 (1): 5-17. 10.1002\/mus.21428.","journal-title":"Muscle Nerve"},{"issue":"9","key":"271_CR33","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ng2103","volume":"39","author":"SG Gregory","year":"2007","unstructured":"Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL, Multiple Sclerosis Genetics Group: Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet. 2007, 39 (9): 1083-1091. 10.1038\/ng2103.","journal-title":"Nat Genet"},{"issue":"1","key":"271_CR34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1046\/j.1471-4159.2002.00788.x","volume":"81","author":"WH Hu","year":"2002","unstructured":"Hu WH, Hausmann ON, Yan MS, Walters WM, Wong PK, Bethea JR: Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). J Neurochem. 2002, 81 (1): 36-45. 10.1046\/j.1471-4159.2002.00788.x.","journal-title":"J Neurochem"},{"issue":"43","key":"271_CR35","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005, 102 (43): 15545-15550. 10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci USA"},{"key":"271_CR36","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1186\/1471-2164-11-574","volume":"11","author":"DM Gatti","year":"2010","unstructured":"Gatti DM, Barry WT, Nobel AB, Rusyn I, Wright FA: Heading down the wrong pathway: on the influence of correlation within gene sets. BMC Genomics. 2010, 11: 574-10.1186\/1471-2164-11-574.","journal-title":"BMC Genomics"},{"key":"271_CR37","unstructured":"The KEGG ALS Pathway. [ http:\/\/www.genome.jp\/kegg\/pathway\/hsa\/hsa05014.html ]"},{"key":"271_CR38","unstructured":"The AmiGO gene ontology database. [ http:\/\/amigo.geneontology.org ]"},{"issue":"13","key":"271_CR39","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1091\/mbc.E10-02-0098","volume":"21","author":"NB Nillegoda","year":"2010","unstructured":"Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ: Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins. Mol Biol Cell. 2010, 21 (13): 2102-2116. 10.1091\/mbc.E10-02-0098.","journal-title":"Mol Biol Cell"},{"issue":"5","key":"271_CR40","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1002\/mus.21949","volume":"43","author":"C Jamart","year":"2010","unstructured":"Jamart C, Raymackers JM, Li An G, Deldicque L, Francaux M: Prevention of muscle disuse atrophy by MG132 proteasome inhibitor. Muscle Nerve. 2010, 43 (5): 708-715.","journal-title":"Muscle Nerve"},{"issue":"3","key":"271_CR41","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/j.1471-4159.2010.06961.x","volume":"115","author":"G Kleinberger","year":"2010","unstructured":"Kleinberger G, Wils H, Ponsaerts P, Joris G, Timmermans JP, Van Broeckhoven C, Kumar-Singh S: Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures. J Neurochem. 2010, 115 (3): 735-747. 10.1111\/j.1471-4159.2010.06961.x.","journal-title":"J Neurochem"},{"issue":"5","key":"271_CR42","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/art.10978","volume":"48","author":"EC Jury","year":"2003","unstructured":"Jury EC, Kabouridis PS, Abba A, Mageed RA, Isenberg DA: Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 2003, 48 (5): 1343-1354. 10.1002\/art.10978.","journal-title":"Arthritis Rheum"},{"key":"271_CR43","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/1471-2105-9-505","volume":"9","author":"TT Ni","year":"2008","unstructured":"Ni TT, Lemon WJ, Shyr Y, Zhong TP: Use of normalization methods for analysis of microarrays containing a high degree of gene effects. BMC Bioinformatics. 2008, 9: 505-10.1186\/1471-2105-9-505.","journal-title":"BMC Bioinformatics"},{"key":"271_CR44","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1186\/1471-2105-7-469","volume":"7","author":"A Fujita","year":"2006","unstructured":"Fujita A, Sato JR, Rodrigues Lde O, Ferreira CE, Sogayar MC: Evaluating different methods of microarray data normalization. BMC Bioinformatics. 2006, 7: 469-10.1186\/1471-2105-7-469.","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"271_CR45","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuron.2010.11.036","volume":"68","author":"JO Johnson","year":"2010","unstructured":"Johnson JO, Mandrioli J, Benatar M, Abramzon Y, van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurr\u00f2 MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G, et al: Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010, 68 (5): 857-64. 10.1016\/j.neuron.2010.11.036.","journal-title":"Neuron"},{"issue":"4","key":"271_CR46","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1365-2443.2010.01385.x","volume":"15","author":"K Kume","year":"2010","unstructured":"Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, Handa H: Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells. 2010, 15 (4): 339-49. 10.1111\/j.1365-2443.2010.01385.x.","journal-title":"Genes Cells"},{"issue":"39","key":"271_CR47","doi-asserted-by":"publisher","first-page":"36793","DOI":"10.1074\/jbc.M206559200","volume":"277","author":"J Niwa","year":"2002","unstructured":"Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka K, Taniguchi N, Sobue G: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem. 2002, 277 (39): 36793-36798. 10.1074\/jbc.M206559200.","journal-title":"J Biol Chem"},{"issue":"1","key":"271_CR48","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/jnr.22175","volume":"88","author":"J Sone","year":"2010","unstructured":"Sone J, Niwa J, Kawai K, Ishigaki S, Yamada S, Adachi H, Katsuno M, Tanaka F, Doyu M, Sobue G: Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci Res. 2010, 88 (1): 123-135. 10.1002\/jnr.22175.","journal-title":"J Neurosci Res"},{"issue":"5","key":"271_CR49","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00401-010-0786-7","volume":"121","author":"G De Marco","year":"2011","unstructured":"De Marco G, Lupino E, Calvo A, Moglia C, Buccinn\u00e0 B, Grifoni S, Ramondetti C, Lomartire A, Rinaudo MT, Piccinini M, Giordana MT, Chi\u00f2 A: Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations. Acta Neuropathol. 2011, 121 (5): 611-22. 10.1007\/s00401-010-0786-7.","journal-title":"Acta Neuropathol"},{"key":"271_CR50","doi-asserted-by":"crossref","unstructured":"Hanson KA, Kim SH, Wassarman DA, Tibbetts RS: Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS). J Biol Chem. 285 (15): 11068-11072.","DOI":"10.1074\/jbc.C109.078527"},{"issue":"12","key":"271_CR51","doi-asserted-by":"publisher","first-page":"8083","DOI":"10.1074\/jbc.M808064200","volume":"284","author":"SH Kim","year":"2009","unstructured":"Kim SH, Shi Y, Hanson KA, Williams LM, Sakasai R, Bowler MJ, Tibbetts RS: Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1. J Biol Chem. 2009, 284 (12): 8083-8092. 10.1074\/jbc.M808064200.","journal-title":"J Biol Chem"},{"issue":"7363","key":"271_CR52","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nature10353","volume":"477","author":"HX Deng","year":"2011","unstructured":"Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, Bigio EH, Brooks BR, Ajroud K, Sufit RL, Haines JL, Mugnaini E, Pericak-Vance MA, Siddique T: Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS\/dementia. Nature. 2011, 477 (7363): 211-5. 10.1038\/nature10353.","journal-title":"Nature"},{"key":"271_CR53","doi-asserted-by":"crossref","unstructured":"Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell. 6 (2): 409-19.","DOI":"10.1016\/S1097-2765(00)00040-X"},{"issue":"1-2","key":"271_CR54","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jns.2010.08.026","volume":"298","author":"T Watanabe","year":"2010","unstructured":"Watanabe T, Okeda Y, Yamano T, Ono S: An immunohistochemical study of ubiquitin in the skin of sporadic amyotrophic lateral sclerosis. J Neurol Sci. 2010, 298 (1-2): 52-56. 10.1016\/j.jns.2010.08.026.","journal-title":"J Neurol Sci"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1755-8794-4-74.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1755-8794-4-74\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1755-8794-4-74","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T09:57:28Z","timestamp":1497952648000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/1755-8794-4-74"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,25]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["271"],"URL":"https:\/\/doi.org\/10.1186\/1755-8794-4-74","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,25]]},"article-number":"74"}}