{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:51:04Z","timestamp":1791060664830,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1756-0500-4-202","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T14:59:23Z","timestamp":1308322763000},"source":"Crossref","is-referenced-by-count":31,"title":["Analysis of nitrogen oxides (NOx) in the exhaled breath condensate (EBC) of subjects with asthma as a complement to exhaled nitric oxide (FeNO) measurements: a cross-sectional study"],"prefix":"10.1186","volume":"4","author":[{"given":"Nathalie","family":"Ch\u00e9rot-Kornobis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Hulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Edm\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"de Broucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Matran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Sobaszek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"938_CR1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1067\/mai.2002.124966","volume":"110","author":"J Hunt","year":"2002","unstructured":"Hunt J: Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol. 2002, 110: 28-34. 10.1067\/mai.2002.124966.","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 1","key":"938_CR2","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1016\/j.prrv.2006.04.017","volume":"7","author":"E Baraldi","year":"2006","unstructured":"Baraldi E, Carraro S: Exhaled NO and breath condensate. Paediatr Respir Rev. 2006, 7 (Suppl 1): S20-2.","journal-title":"Paediatr Respir Rev"},{"key":"938_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.coph.2008.04.001","volume":"8","author":"N Snell","year":"2008","unstructured":"Snell N, Newbold P: The clinical utility of biomarkers in asthma and COPD. Curr Opin Pharmacol. 2008, 8: 222-35. 10.1016\/j.coph.2008.04.001.","journal-title":"Curr Opin Pharmacol"},{"key":"938_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/ACI.0b013e32831d8144","volume":"9","author":"F Hoffmeyer","year":"2009","unstructured":"Hoffmeyer F, Raulf-Heimsoth M, Br\u00fcning T: Exhaled breath condensate and airway inflammation. Curr Opin Allergy Clin Immunol. 2009, 9: 16-22. 10.1097\/ACI.0b013e32831d8144.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"938_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1183\/09031936.00138707","volume":"31","author":"ED Bateman","year":"2008","unstructured":"Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ: Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008, 31: 143-78. 10.1183\/09031936.00138707.","journal-title":"Eur Respir J"},{"key":"938_CR6","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/S0140-6736(08)61450-6","volume":"372","author":"U Frey","year":"2008","unstructured":"Frey U, Suki B: Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control. Lancet. 2008, 372: 1088-99. 10.1016\/S0140-6736(08)61450-6.","journal-title":"Lancet"},{"key":"938_CR7","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1164\/rccm.200609-1346OC","volume":"176","author":"J Travers","year":"2007","unstructured":"Travers J, Marsh S, Aldington S, Williams M, Shirtcliffe P, Pritchard A, Weatherall M, Beasley R: Reference ranges for exhaled nitric oxide derived from a random community survey of adults. Am J Respir Crit Care Med. 2007, 176: 238-42. 10.1164\/rccm.200609-1346OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"938_CR8","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1164\/rccm.200409-1242OC","volume":"171","author":"A Zacharasiewicz","year":"2005","unstructured":"Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T, Khan M, Bush A: Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med. 2005, 171: 1077-82. 10.1164\/rccm.200409-1242OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"938_CR9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/thx.2004.023374","volume":"60","author":"MW Pijnenburg","year":"2005","unstructured":"Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC: Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax. 2005, 60: 215-8. 10.1136\/thx.2004.023374.","journal-title":"Thorax"},{"key":"938_CR10","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.2174\/092986709788803178","volume":"16","author":"G Hillas","year":"2009","unstructured":"Hillas G, Loukides S, Kostikas K, Bakakos P: Biomarkers Obtained by Non-Invasive Methods in Patients with COPD: Where do we Stand, what do we Expect?. Curr Med Chem. 2009, 16: 2824-38. 10.2174\/092986709788803178.","journal-title":"Curr Med Chem"},{"key":"938_CR11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.2174\/092986708783769768","volume":"15","author":"A Koutsokera","year":"2008","unstructured":"Koutsokera A, Loukides S, Gourgoulianis KI, Kostikas K: Biomarkers in the exhaled breath condensate of healthy adults: mapping the path towards reference values. Curr Med Chem. 2008, 15: 620-30. 10.2174\/092986708783769768.","journal-title":"Curr Med Chem"},{"key":"938_CR12","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1164\/ajrccm.163.7.2009041","volume":"163","author":"SA Kharitonov","year":"2001","unstructured":"Kharitonov SA, Barnes PJ: Exhaled markers of pulmonary disease. Am J Respir Crit Care Med. 2001, 163: 1693-722.","journal-title":"Am J Respir Crit Care Med"},{"key":"938_CR13","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/ppul.20469","volume":"41","author":"J Morton","year":"2006","unstructured":"Morton J, Henry RL, Thomas PS, Ratnawati with: Exhaled breath condensate nitrite\/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide. Pediatr Pulmonol. 2006, 41: 929-36. 10.1002\/ppul.20469.","journal-title":"Pediatr Pulmonol"},{"key":"938_CR14","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1164\/ajrccm.163.4.2001108","volume":"163","author":"M Corradi","year":"2001","unstructured":"Corradi M, Montuschi P, Donnelly LE, Pesci A, Kharitonov SA, Barnes PJ: Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am J Respir Crit Care Med. 2001, 163: 854-8.","journal-title":"Am J Respir Crit Care Med"},{"key":"938_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0162-3109(00)00220-4","volume":"48","author":"RA Robbins","year":"2000","unstructured":"Robbins RA, Hadeli K, Nelson D, Sato E, Hoyt JC: Nitric oxide, peroxynitrite, and lower respiratory tract inflammation. Immunopharmacology. 2000, 48: 217-21. 10.1016\/S0162-3109(00)00220-4.","journal-title":"Immunopharmacology"},{"key":"938_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2223\/JPED.1964","volume":"86","author":"CR de Andrade","year":"2010","unstructured":"de Andrade CR, Chatkin JM, Camargos PAM: Assessing clinical and spirometric control and the intensity of the inflammatory process in asthma. J Pediatr (Rio J). 2010, 86: 93-100. 10.2223\/JPED.1964.","journal-title":"J Pediatr (Rio J)"},{"key":"938_CR17","unstructured":"Medical Research Council's Committee on Environmental and Occupational Health. Questionnaire on respiratory symptoms. London, 1986."},{"key":"938_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1183\/09031936.05.00034505","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J: General considerations for lung function testing. Eur Respir J. 2005, 26: 153-61. 10.1183\/09031936.05.00034505.","journal-title":"Eur Respir J"},{"key":"938_CR19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J: Standardisation of spirometry. Eur Respir J. 2005, 26: 319-38. 10.1183\/09031936.05.00034805.","journal-title":"Eur Respir J"},{"key":"938_CR20","doi-asserted-by":"crossref","unstructured":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005, 171: 912-30.","DOI":"10.1164\/rccm.200406-710ST"},{"key":"938_CR21","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1152\/jappl.1998.85.2.642","volume":"85","author":"NM Tsoukias","year":"1998","unstructured":"Tsoukias NM, Tannous Z, Wilson AF, George SC: Single-exhalation profiles of NO and CO2 in humans: effect of dynamically changing flow rate. J Appl Physiol. 1998, 85: 642-52.","journal-title":"J Appl Physiol"},{"key":"938_CR22","doi-asserted-by":"publisher","first-page":"6S29","DOI":"10.1016\/S0761-8425(06)72078-2","volume":"23","author":"B Mahut","year":"2006","unstructured":"Mahut B, Louis B, Delclaux C: Measurement of exhaled nitric oxide: methodology. Rev Mal Respir. 2006, 23: 6S29-26S36.","journal-title":"Rev Mal Respir"},{"issue":"Suppl1","key":"938_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0761-8425(06)72430-5","volume":"23","author":"JL Edm\u00e9","year":"2006","unstructured":"Edm\u00e9 JL, Nisse C, Lepage N, Matran R, Sobaszek A, Boulenguez C: \u00c9valuation de la mesure du NO expir\u00e9 par deux techniques: \u00e9tude de reproductibilit\u00e9. Rev Mal Respir. 2006, 23 (Suppl1): 115-","journal-title":"Rev Mal Respir"},{"key":"938_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00011-007-7136-9","volume":"57","author":"JL Edm\u00e9","year":"2008","unstructured":"Edm\u00e9 JL, Tellart AS, Launay D, Neviere R, Grutzmacher C, Boulenguez C, Labalette M, Hachulla E, Hatron PY, Dessaint JP, Matran R, Sobaszek A: Cytokine concentrations in exhaled breath condensates in systemic sclerosis. Inflamm Res. 2008, 57: 151-6. 10.1007\/s00011-007-7136-9.","journal-title":"Inflamm Res"},{"key":"938_CR25","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1183\/09031936.05.00029705","volume":"26","author":"I Horv\u00e1th","year":"2005","unstructured":"Horv\u00e1th I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJC, Corradi M, Dekhuijzen R, Dweik RA, Dwyer T, Effros R, Erzurum S, Gaston B, Gessner C, Greening A, Ho LP, Hohlfeld J, J\u00f6bsis Q, Laskowski D, Loukides S, Marlin D, Montuschi P, Olin AC, Redington AE, Reinhold P, van Rensen ELJ, Rubinstein I, Silkoff P, Toren K, Vass G, Vogelberg C, Wirtz H: Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 2005, 26: 523-48. 10.1183\/09031936.05.00029705.","journal-title":"Eur Respir J"},{"key":"938_CR26","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1136\/thx.46.6.454","volume":"46","author":"S Chinn","year":"1991","unstructured":"Chinn S: Statistics in respiratory medicine. 2. Repeatability and method comparison. Thorax. 1991, 46: 454-456. 10.1136\/thx.46.6.454.","journal-title":"Thorax"},{"key":"938_CR27","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1111\/j.1365-2222.2008.02940.x","volume":"38","author":"K Kostikas","year":"2008","unstructured":"Kostikas K, Koutsokera A, Papiris S, Gourgoulianis KI, Loukides S: Exhaled breath condensate in patients with asthma: implications for application in clinical practice. Clin Exp Allergy. 2008, 38: 557-65. 10.1111\/j.1365-2222.2008.02940.x.","journal-title":"Clin Exp Allergy"},{"key":"938_CR28","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1183\/09031936.06.00110305","volume":"28","author":"PP Rosias","year":"2006","unstructured":"Rosias PP, Robroeks CM, Niemarkt HJ, Kester AD, Vernooy JH, Suykerbuyk J, Teunissen J, Heynens J, Hendriks HJ, J\u00f6bsis Q, Dompeling E: Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate. Eur Respir J. 2006, 28: 1036-41. 10.1183\/09031936.06.00110305.","journal-title":"Eur Respir J"},{"key":"938_CR29","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1183\/09031936.00080207","volume":"30","author":"J Liu","year":"2007","unstructured":"Liu J, Conrad DH, Chow S, Tran VH, Yates DH, Thomas PS: Collection devices influence the constituents of exhaled breath condensate. Eur Respir J. 2007, 30: 807-8. 10.1183\/09031936.00080207.","journal-title":"Eur Respir J"},{"key":"938_CR30","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1016\/j.rmed.2007.02.023","volume":"101","author":"L Prieto","year":"2007","unstructured":"Prieto L, Ferrer A, Palop J, Domenech J, Llusar R, Rojas R: Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices. Respir Med. 2007, 101: 1715-20. 10.1016\/j.rmed.2007.02.023.","journal-title":"Respir Med"},{"key":"938_CR31","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1183\/09031936.00085408","volume":"32","author":"S Chow","year":"2008","unstructured":"Chow S, Yates DH, Thomas PS: Reproducibility of exhaled breath condensate markers. Eur Respir J. 2008, 32: 1124-6. 10.1183\/09031936.00085408.","journal-title":"Eur Respir J"},{"key":"938_CR32","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1136\/thx.54.12.1061","volume":"54","author":"JA Nightingale","year":"1999","unstructured":"Nightingale JA, Rogers DF, Barnes PJ: Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects. Thorax. 1999, 54: 1061-9. 10.1136\/thx.54.12.1061.","journal-title":"Thorax"},{"key":"938_CR33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000088050","volume":"73","author":"J Chladkova","year":"2006","unstructured":"Chladkova J, Krcmova I, Chladek J, Cap P, Micuda S, Hanzalkova Y: Validation of nitrite and nitrate measurements in exhaled breath condensate. Respiration. 2006, 73: 173-9. 10.1159\/000088050.","journal-title":"Respiration"},{"key":"938_CR34","first-page":"CR416","volume":"14","author":"C Vogelberg","year":"2008","unstructured":"Vogelberg C, Kahlert A, W\u00fcrfel C, Marx K, B\u00f6hm A, Range U, Neumeister V, Leupold W: Exhaled breath condensate nitrite--methodological problems of sample collection. Med Sci Monit. 2008, 14: CR416-22.","journal-title":"Med Sci Monit"},{"key":"938_CR35","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/jcla.20286","volume":"23","author":"S Dodig","year":"2009","unstructured":"Dodig S, Vlasi\u0107 Z, Cepelak I, Zrinski Topi\u0107 R, Turkalj M, Nogalo B: Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease. J Clin Lab Anal. 2009, 23: 34-9. 10.1002\/jcla.20286.","journal-title":"J Clin Lab Anal"},{"key":"938_CR36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S1081-1206(10)60140-8","volume":"103","author":"V Mehta","year":"2009","unstructured":"Mehta V, Stokes JR, Berro A, Romero FA, Casale TB: Time-dependent effects of inhaled corticosteroids on lung function, bronchial hyperresponsiveness, and airway inflammation in asthma. Ann Allergy Asthma Immunol. 2009, 103: 31-7. 10.1016\/S1081-1206(10)60140-8.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"938_CR37","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1378\/chest.125.1.22","volume":"125","author":"KW Garey","year":"2004","unstructured":"Garey KW, Neuhauser MM, Robbins RA, Danziger LH, Rubinstein I: Markers of inflammation in exhaled breath condensate of young healthy smokers. Chest. 2004, 125: 22-6. 10.1378\/chest.125.1.22.","journal-title":"Chest"},{"key":"938_CR38","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1378\/chest.06-2928","volume":"131","author":"AC Olin","year":"2007","unstructured":"Olin AC, Bake B, Tor\u00e9n K: Fraction of exhaled nitric oxide at 50 mL\/s: reference values for adult lifelong never-smokers. Chest. 2007, 131: 1852-6. 10.1378\/chest.06-2928.","journal-title":"Chest"},{"key":"938_CR39","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1378\/chest.08-1007","volume":"135","author":"MJ Cruz","year":"2009","unstructured":"Cruz MJ, S\u00e1nchez-Vidaurre S, Romero PV, Morell F, Mu\u00f1oz X: Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate. Chest. 2009, 135: 462-7. 10.1378\/chest.08-1007.","journal-title":"Chest"},{"key":"938_CR40","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1440-1843.2008.01315.x","volume":"13","author":"T Ueno","year":"2008","unstructured":"Ueno T, Kataoka M, Hirano A, Iio K, Tanimoto Y, Kanehiro A, Okada C, Soda R, Takahashi K, Tanimoto M: Inflammatory markers in exhaled breath condensate from patients with asthma. Respirology. 2008, 13: 654-63. 10.1111\/j.1440-1843.2008.01315.x.","journal-title":"Respirology"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-0500-4-202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-0500-4-202\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-0500-4-202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T20:46:01Z","timestamp":1548103561000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/1756-0500-4-202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,16]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["938"],"URL":"https:\/\/doi.org\/10.1186\/1756-0500-4-202","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,16]]},"article-number":"202"}}