{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:15:19Z","timestamp":1792660519012,"version":"4.5.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The saw-tooth sign was first described by Sanders et al in patients with obstructive sleep apnea syndrome as one cause of extrathoracic central airway obstruction. The mechanism of the saw-tooth sign has not been conclusively clarified. The sign has also been described in various extrathoracic central airway diseases, such as in burn victims with thermal injury to the upper airways, Parkinson\u2019s disease, tracheobronchomalacia, laryngeal dyskinesia, and pedunculated tumors of the upper airway.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 61-year-old man was referred to our hospital with a two-month history of persistent dry cough and dyspnea. He was diagnosed with lung cancer located in an intrathoracic central airway, which was accompanied by the saw-tooth sign on flow-volume loops. This peculiar sign repeatedly improved and deteriorated, in accordance with the waxing and waning of central airway stenosis by anti-cancer treatments.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This report suggests that the so-called saw-tooth sign may be found even in intrathoracic central airway obstruction due to lung cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1756-0500-5-388","type":"journal-article","created":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T02:16:58Z","timestamp":1343528218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The saw-tooth sign as a clinical clue for intrathoracic central airway obstruction"],"prefix":"10.1186","volume":"5","author":[{"given":"Akira","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saraya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyuki","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidefumi","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,29]]},"reference":[{"key":"1603_CR1","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1001\/jama.1981.03310480030021","volume":"245","author":"MH Sanders","year":"1981","unstructured":"Sanders MH, Martin RJ, Pennock BE: The detection of sleep apnea in the awake patient. The 'saw-tooth' sign. JAMA. 1981, 245: 2414-2418. 10.1001\/jama.1981.03310480030021.","journal-title":"JAMA"},{"key":"1603_CR2","first-page":"251","volume":"129","author":"EF Haponik","year":"1984","unstructured":"Haponik EF, Munster AM, Wise RA: Upper airway function in burn patients. Correlation of flow-volume curves and nasopharyngoscopy. Am Rev Respir Dis. 1984, 129: 251-257.","journal-title":"Am Rev Respir Dis"},{"key":"1603_CR3","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1378\/chest.87.1.124","volume":"87","author":"PL Schiffman","year":"1985","unstructured":"Schiffman PL: A \"saw-tooth\" pattern in Parkinson's disease. Chest. 1985, 87: 124-126. 10.1378\/chest.87.1.124.","journal-title":"Chest"},{"key":"1603_CR4","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1378\/chest.88.3.480-a","volume":"88","author":"W Vincken","year":"1985","unstructured":"Vincken W, Cosio MG: \"Saw-tooth\" pattern in the flow-volume loop. Chest. 1985, 88: 480-481.","journal-title":"Chest"},{"key":"1603_CR5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1378\/chest.118.1.262","volume":"118","author":"MT Newhouse","year":"2000","unstructured":"Newhouse MT, Martin L, Kay JM: Laser resection of a pedunculated tracheal adenoma. Chest. 2000, 118: 262-266. 10.1378\/chest.118.1.262.","journal-title":"Chest"},{"key":"1603_CR6","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1017\/S0022215100142239","volume":"112","author":"N Rendleman","year":"1998","unstructured":"Rendleman N, Quinn SF: The answer is blowing in the wind: a pedunculated tumour with saw tooth flow-volume loop. J Laryngol Otol. 1998, 112: 973-975.","journal-title":"J Laryngol Otol"},{"key":"1603_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000222508","volume":"78","author":"JA Verbraecken","year":"2009","unstructured":"Verbraecken JA, De Backer WA: Upper airway mechanics. Respiration. 2009, 78: 121-133. 10.1159\/000222508.","journal-title":"Respiration"},{"key":"1603_CR8","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1378\/chest.118.5.1519","volume":"118","author":"E Garcia-Pachon","year":"2000","unstructured":"Garcia-Pachon E: Tracheobronchomalacia: a cause of flow oscillations on the flow-volume loop. Chest. 2000, 118: 1519-10.1378\/chest.118.5.1519.","journal-title":"Chest"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-0500-5-388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T19:41:36Z","timestamp":1630525296000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/1756-0500-5-388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,29]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1603"],"URL":"https:\/\/doi.org\/10.1186\/1756-0500-5-388","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,29]]},"assertion":[{"value":"29 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"388"}}