{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:44:32Z","timestamp":1790621072967,"version":"4.1.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Musculoskeletal involvement occurs in 25% of patients with non-Hodgkin\u2019s lymphoma (NHL). Primary lymphoma in the joint is rare. It can present as a bone lesion or as atypical soft tissue proliferation. NHL has an increased incidence in patients with autoimmune rheumatic diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We present a case in which non-Hodgkin\u2019s lymphoma was found coincidentally in the synovium during knee joint replacement surgery in a 69-year old woman with rheumatoid arthritis. Pigmented, vitreous tissue was resected, which turned out to be a diffuse large B-cell lymphoma after histological examination. The coincidental intraoperative finding of intra-articular non-Hodgkin\u2019s lymphoma was reported twice before, presenting as synovial proliferation in elbow and shoulder surgery. In a few other cases non-Hodgkin\u2019s lymphoma presented most often in the knee, as a bone lesion or, when soft tissue was involved, as arthritis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Non-Hodgkin\u2019s lymphoma should be considered in patients with autoimmune rheumatic diseases. In case of persistent arthritis, non-respondent to anti-inflammatory drugs, a biopsy might be warranted. Moreover, when arthroscopy or arthrotomy is planned, any atypical tissue should be sent for histological analysis. Early diagnosis of NHL can contribute to improved outcome of its rapidly developing treatment options.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1756-0500-5-449","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:14:30Z","timestamp":1345508070000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Non-Hodgkin\u2019s Lymphoma of the synovium discovered in total knee arthroplasty: a case report"],"prefix":"10.1186","volume":"5","author":[{"given":"Jetze","family":"Visser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent JJF","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineke M","family":"de Kievit-van der Heijden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno M","family":"ten Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"1859_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/art.1780300205","volume":"30","author":"HD Dorfman","year":"1987","unstructured":"Dorfman HD, Siegel HL, Perry MC, Oxenhandler R: Non-Hodgkin's lymphoma of the synovium simulating rheumatoid arthritis. Arthritis Rheum. 1987, 30: 155-161. 10.1002\/art.1780300205.","journal-title":"Arthritis Rheum"},{"key":"1859_CR2","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.2106\/JBJS.E.00094","volume":"88","author":"A Jawa","year":"2006","unstructured":"Jawa A, Lieberman AE, Alexieva CC, Jupiter JB: Primary intra-articular non-Hodgkin's lymphoma of the elbow. A case report. J Bone Joint Surg Am. 2006, 88: 2730-2734. 10.2106\/JBJS.E.00094.","journal-title":"J Bone Joint Surg Am"},{"key":"1859_CR3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.arthro.2006.01.016","volume":"23","author":"J Mileti","year":"2007","unstructured":"Mileti J, Mileti L, Kaeding C: Non-Hodgkin's lymphoma of the knee diagnosed by arthroscopy. Arthroscopy. 2007, 23: 447-e441-444","journal-title":"Arthroscopy"},{"key":"1859_CR4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00402-002-0427-2","volume":"122","author":"R Vadivelu","year":"2002","unstructured":"Vadivelu R, Kar N, Margetts MJ, Abdul-Cader AH: Non-Hodgkin's lymphoma as an unexpected diagnosis in a hip arthroplasty. Arch Orthop Trauma Surg. 2002, 122: 532-534.","journal-title":"Arch Orthop Trauma Surg"},{"key":"1859_CR5","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.arth.2007.02.014","volume":"23","author":"AJ Watson","year":"2008","unstructured":"Watson AJ, Cross MJ: Non-Hodgkin lymphoma as an unexpected diagnosis after elective total knee arthroplasty. J Arthroplasty. 2008, 23: 612-614. 10.1016\/j.arth.2007.02.014.","journal-title":"J Arthroplasty"},{"key":"1859_CR6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1471-2474-10-53","volume":"10","author":"EW Zwitser","year":"2009","unstructured":"Zwitser EW, de Gast A, Basie MJ, van Kemenade FJ, van Royen BJ: B-cell lymphoma in retrieved femoral heads: a long term follow up. BMC Musculoskelet Disord. 2009, 10: 53-10.1186\/1471-2474-10-53.","journal-title":"BMC Musculoskelet Disord"},{"key":"1859_CR7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/S0883-5403(99)90211-5","volume":"14","author":"J Arredondo","year":"1999","unstructured":"Arredondo J, Worland RL, Sinnenberg RJ, Qureshi GD: Non-Hodgkin's lymphoma as an unexpected diagnosis in a shoulder arthroplasty. J Arthroplasty. 1999, 14: 108-111. 10.1016\/S0883-5403(99)90211-5.","journal-title":"J Arthroplasty"},{"key":"1859_CR8","doi-asserted-by":"publisher","first-page":"4310","DOI":"10.1200\/JCO.2007.12.7092","volume":"25","author":"J Ikeda","year":"2007","unstructured":"Ikeda J, Morii E, Yamauchi A, Kohara M, Hashimoto N, Yoshikawa H, Iwasaki M, Aozasa K: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type developing in gonarthritis deformans. J Clin Oncol. 2007, 25: 4310-4312. 10.1200\/JCO.2007.12.7092.","journal-title":"J Clin Oncol"},{"key":"1859_CR9","first-page":"2573","volume":"28","author":"G Starkebaum","year":"2001","unstructured":"Starkebaum G: Rheumatoid arthritis, methotrexate, and lymphoma: risk substitution, or cat and mouse with Epstein-Barr virus?. J Rheumatol. 2001, 28: 2573-2575.","journal-title":"J Rheumatol"},{"key":"1859_CR10","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nrrheum.2011.62","volume":"7","author":"C Dias","year":"2011","unstructured":"Dias C, Isenberg DA: Susceptibility of patients with rheumatic diseases to B-cell non-Hodgkin lymphoma. Nat Rev Rheumatol. 2011, 7: 360-368. 10.1038\/nrrheum.2011.62.","journal-title":"Nat Rev Rheumatol"},{"key":"1859_CR11","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/art.21675","volume":"54","author":"E Baecklund","year":"2006","unstructured":"Baecklund E, Iliadou A, Askling J, Ekbom A, Backlin C, Granath F, Catrina AI, Rosenquist R, Feltelius N, Sundstrom C, Klareskog L: Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum. 2006, 54: 692-701. 10.1002\/art.21675.","journal-title":"Arthritis Rheum"},{"key":"1859_CR12","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3816\/CLML.2010.n.086","volume":"10","author":"CR Flowers","year":"2010","unstructured":"Flowers CR, Armitage JO: A decade of progress in lymphoma: advances and continuing challenges. Clin Lymphoma Myeloma Leuk. 2010, 10: 414-423. 10.3816\/CLML.2010.n.086.","journal-title":"Clin Lymphoma Myeloma Leuk"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-0500-5-449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T20:51:56Z","timestamp":1630529516000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/1756-0500-5-449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,20]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1859"],"URL":"https:\/\/doi.org\/10.1186\/1756-0500-5-449","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,20]]},"assertion":[{"value":"12 July 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"449"}}