{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:49:44Z","timestamp":1758862184493},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pregnant women are more susceptible to severe<jats:italic>Plasmodium falciparum<\/jats:italic>malaria, which can lead to poor maternal and fetal outcomes. Few data exist on the epidemiology of severe<jats:italic>P. falciparum<\/jats:italic>malaria in pregnant women.<\/jats:p><jats:p>A hospital-based study was carried out to assess the pattern of severe<jats:italic>P. falciparum<\/jats:italic>malaria among pregnant women at the Kassala and Medani maternity hospitals, which are located in areas of unstable malaria transmission, in eastern and central Sudan, respectively. Pre-tested questionnaires were used to gather socio-demographic, clinical and obstetrical data. Suitable tests were performed for clinical and biochemical investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 222 pregnant women diagnosed with malaria at the two hospitals, 40 (18.0%) women at mean (SD) gestational age of 29.3 (6.7) weeks fulfilled one or more of the WHO criteria for severe<jats:italic>P. falciparum<\/jats:italic>malaria. These were hypoglycaemia (14; 35.5%), severe anaemia (12; 30%), hypotension (10; 25%), jaundice (9; 22.5%), cerebral malaria (6; 15%), repeated convulsions (4; 10%), hyperparasitaemia (4; 10.0%) and more than one manifestation (9; 22.5%). While the mean (SD) presenting temperature was significantly lower for women presenting with hypoglycaemia [38.2(0.6) versus 38.8(0.7) \u00b0C,<jats:italic>P<\/jats:italic>= 0.04], other clinical and biochemical characteristics were not significantly different among women with different manifestations of severe<jats:italic>P. falciparum<\/jats:italic>malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preventive measures for pregnant women such as insecticide-treated bednets and chemoprophylaxis may be beneficial in areas of unstable malaria transmission. Early detection and prompt treatment of severe malaria, especially in pregnant women with hypoglycaemia, are needed.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1756-3305-4-88","type":"journal-article","created":{"date-parts":[[2011,5,24]],"date-time":"2011-05-24T06:45:08Z","timestamp":1306219508000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hypoglycaemia and severe plasmodium falciparum malaria among pregnant sudanese women in an area characterized by unstable malaria transmission"],"prefix":"10.1186","volume":"4","author":[{"given":"Aziem A","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elhassan M","family":"Elhassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoun M","family":"Magzoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa I","family":"Elbashir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishag","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,5,23]]},"reference":[{"key":"329_CR1","volume-title":"WHO Regional Office for Africa","author":"World Health Organization","year":"2004","unstructured":"World Health Organization: Strategic Framework for Malaria Control during Pregnancy in the WHO Africa Region, Brazzaville. 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