{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:02:21Z","timestamp":1776445341810,"version":"3.51.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1756-3305-6-154","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T12:15:04Z","timestamp":1369829704000},"source":"Crossref","is-referenced-by-count":31,"title":["Characterization of mouse brain microRNAs after infection with cyst-forming Toxoplasma gondii"],"prefix":"10.1186","volume":"6","author":[{"given":"Min-Jun","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasdair J","family":"Nisbet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Fan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"937_CR1","first-page":"313","volume-title":"Toxoplasmosis of Animals and Humans","author":"JP Dubey","year":"2010","unstructured":"Dubey JP: Toxoplasmosis of Animals and Humans. 2010, Boca Raton, Florida: CRC Press, 313-"},{"key":"937_CR2","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/1756-3305-4-240","volume":"4","author":"S Nardoni","year":"2011","unstructured":"Nardoni S, Angelici MC, Mugnaini L, Mancianti F: Prevalence of Toxoplasma gondii infection in Myocastor coypus in a protected Italian wetland. Parasit Vectors. 2011, 4: 240-10.1186\/1756-3305-4-240.","journal-title":"Parasit Vectors"},{"key":"937_CR3","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1756-3305-5-152","volume":"5","author":"J Chen","year":"2012","unstructured":"Chen J, Xu MJ, Zhou DH, Song HQ, Wang CR, Zhu XQ: Canine and feline parasitic zoonoses in China. Parasit Vectors. 2012, 5: 152-10.1186\/1756-3305-5-152.","journal-title":"Parasit Vectors"},{"key":"937_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/1756-3305-5-205","volume":"5","author":"YM Tian","year":"2012","unstructured":"Tian YM, Dai FY, Huang SY, Deng ZH, Duan G, Zhou DH, Yang JF, Weng YB, Zhu XQ, Zou FC: First report of Toxoplasma gondii seroprevalence in peafowls in Yunnan Province. Southwestern China. Parasit Vectors. 2012, 5: 205-10.1186\/1756-3305-5-205.","journal-title":"Parasit Vectors"},{"key":"937_CR5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1756-3305-4-165","volume":"4","author":"P Zhou","year":"2011","unstructured":"Zhou P, Chen Z, Li HL, Zheng H, He S, Lin RQ, Zhu XQ: Toxoplasma gondii infection in humans in China. Parasit Vectors. 2011, 4: 165-10.1186\/1756-3305-4-165.","journal-title":"Parasit Vectors"},{"key":"937_CR6","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"JG Montoya","year":"2004","unstructured":"Montoya JG, Liesenfeld O: Toxoplasmosis. Lancet. 2004, 363: 1965-1976. 10.1016\/S0140-6736(04)16412-X.","journal-title":"Lancet"},{"key":"937_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/359082a0","volume":"359","author":"LD Sibley","year":"1992","unstructured":"Sibley LD, Boothroyd JC: Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature. 1992, 359: 82-85. 10.1038\/359082a0.","journal-title":"Nature"},{"key":"937_CR8","doi-asserted-by":"publisher","first-page":"e1001328","DOI":"10.1371\/journal.ppat.1001328","volume":"7","author":"A Olguin-Lamas","year":"2011","unstructured":"Olguin-Lamas A, Madec E, Hovasse A, Werkmeister E, Callebaut I, Slomianny C, Delhaye S, Mouveaux T, Schaeffer-Reiss C, Van Dorsselaer A, Tomavo S: A novel Toxoplasma gondii nuclear factor TgNF3 is a dynamic chromatin-associated component, modulator of nucleolar architecture and parasite virulence. PLoS Pathog. 2011, 7: e1001328-10.1371\/journal.ppat.1001328.","journal-title":"PLoS Pathog"},{"key":"937_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrmicro1800","volume":"6","author":"JC Boothroyd","year":"2008","unstructured":"Boothroyd JC, Dubremetz JF: Kiss and spit: the dual roles of Toxoplasma rhoptries. Nat Rev Microbiol. 2008, 6: 79-88. 10.1038\/nrmicro1800.","journal-title":"Nat Rev Microbiol"},{"key":"937_CR10","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1126\/science.1133690","volume":"314","author":"JP Saeij","year":"2006","unstructured":"Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC: Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006, 314: 1780-1783. 10.1126\/science.1133690.","journal-title":"Science"},{"key":"937_CR11","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature05395","volume":"445","author":"JP Saeij","year":"2007","unstructured":"Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC: Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007, 445: 324-327. 10.1038\/nature05395.","journal-title":"Nature"},{"key":"937_CR12","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1462-5822.2008.01117.x","volume":"10","author":"RE Molestina","year":"2008","unstructured":"Molestina RE, El-Guendy N, Sinai AP: Infection with Toxoplasma gondii results in dysregulation of the host cell cycle. Cell Microbiol. 2008, 10: 1153-1165. 10.1111\/j.1462-5822.2008.01117.x.","journal-title":"Cell Microbiol"},{"key":"937_CR13","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/cr.2007.67","volume":"17","author":"T Du","year":"2007","unstructured":"Du T, Zamore PD: Beginning to understand microRNA function. Cell Res. 2007, 17: 661-663. 10.1038\/cr.2007.67.","journal-title":"Cell Res"},{"key":"937_CR14","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1126\/science.1080372","volume":"299","author":"LP Lim","year":"2003","unstructured":"Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP: Vertebrate microRNA genes. Science. 2003, 299: 1540-10.1126\/science.1080372.","journal-title":"Science"},{"key":"937_CR15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00436-010-1927-6","volume":"107","author":"Q Liu","year":"2010","unstructured":"Liu Q, Tuo W, Gao H, Zhu XQ: MicroRNAs of parasites: current status and future perspectives. Parasitol Res. 2010, 107: 501-507. 10.1007\/s00436-010-1927-6.","journal-title":"Parasitol Res"},{"key":"937_CR16","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ygeno.2009.01.004","volume":"93","author":"WC Lin","year":"2009","unstructured":"Lin WC, Li SC, Lin WC, Shin JW, Hu SN, Yu XM, Huang TY, Chen SC, Chen HC, Chen SJ, Huang PJ, Gan RR, Chiu CH, Tang P: Identification of microRNA in the protist Trichomonas vaginalis. Genomics. 2009, 93: 487-493. 10.1016\/j.ygeno.2009.01.004.","journal-title":"Genomics"},{"key":"937_CR17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/nrmicro2971","volume":"11","author":"BR TenOever","year":"2013","unstructured":"TenOever BR: RNA viruses and the host microRNA machinery. Nat Rev Microbiol. 2013, 11: 169-180. 10.1038\/nrmicro2971.","journal-title":"Nat Rev Microbiol"},{"key":"937_CR18","doi-asserted-by":"publisher","first-page":"246","DOI":"10.4161\/cc.23273","volume":"12","author":"H Zhai","year":"2013","unstructured":"Zhai H, Fesler A, Ju J: MicroRNA: a third dimension in autophagy. Cell Cycle. 2013, 12: 246-250. 10.4161\/cc.23273.","journal-title":"Cell Cycle"},{"key":"937_CR19","doi-asserted-by":"publisher","first-page":"e8742","DOI":"10.1371\/journal.pone.0008742","volume":"5","author":"GM Zeiner","year":"2010","unstructured":"Zeiner GM, Norman KL, Thomson JM, Hammond SM, Boothroyd JC: Toxoplasma gondii infection specifically increases the levels of key host microRNAs. PLoS One. 2010, 5: e8742-10.1371\/journal.pone.0008742.","journal-title":"PLoS One"},{"key":"937_CR20","doi-asserted-by":"publisher","first-page":"D391","DOI":"10.2741\/Weiss","volume":"5","author":"LM Weiss","year":"2000","unstructured":"Weiss LM, Kim K: The development and biology of bradyzoites of Toxoplasma gondii. Front Biosci. 2000, 5: D391-D405. 10.2741\/Weiss.","journal-title":"Front Biosci"},{"key":"937_CR21","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0171-2985(99)80065-5","volume":"201","author":"W Bohne","year":"1999","unstructured":"Bohne W, Holpert M, Gross U: Stage differentiation of the protozoan parasite Toxoplasma gondii. Immunobiology. 1999, 201: 248-254. 10.1016\/S0171-2985(99)80065-5.","journal-title":"Immunobiology"},{"key":"937_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1750-9378-8-8","volume":"8","author":"S Thirugnanam","year":"2013","unstructured":"Thirugnanam S, Rout N, Gnanasekar M: Possible role of Toxoplasma gondii in brain cancer through modulation of host microRNAs. Infect Agent Cancer. 2013, 8: 8-10.1186\/1750-9378-8-8.","journal-title":"Infect Agent Cancer"},{"key":"937_CR23","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1756-3305-6-96","volume":"6","author":"DH Zhou","year":"2013","unstructured":"Zhou DH, Zhao FR, Huang SY, Xu MJ, Song HQ, Su C, Zhu XQ: Changes in the proteomic profiles of mouse brain after infection with cyst-forming Toxoplasma gondii. Parasit Vectors. 2013, 6: 96-10.1186\/1756-3305-6-96.","journal-title":"Parasit Vectors"},{"key":"937_CR24","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/1471-2164-11-521","volume":"11","author":"MJ Xu","year":"2010","unstructured":"Xu MJ, Liu Q, Nisbet AJ, Cai XQ, Yan C, Lin RQ, Yuan ZG, Song HQ, He XH, Zhu XQ: Identification and characterization of microRNAs in Clonorchis sinensis of human health significance. BMC Genomics. 2010, 11: 521-10.1186\/1471-2164-11-521.","journal-title":"BMC Genomics"},{"key":"937_CR25","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1093\/bioinformatics\/btp336","volume":"25","author":"R Li","year":"2009","unstructured":"Li R, Yu C, Li Y, Lam TW, Yiu SM, Kristiansen K, Wang J: SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics. 2009, 25: 1966-1967. 10.1093\/bioinformatics\/btp336.","journal-title":"Bioinformatics"},{"key":"937_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005, 120: 15-20. 10.1016\/j.cell.2004.12.035.","journal-title":"Cell"},{"key":"937_CR27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","volume":"27","author":"A Grimson","year":"2007","unstructured":"Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP: MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007, 27: 91-105. 10.1016\/j.molcel.2007.06.017.","journal-title":"Mol Cell"},{"key":"937_CR28","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, Lao KQ, Livak KJ, Guegler KJ: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005, 33: e179-10.1093\/nar\/gni178.","journal-title":"Nucleic Acids Res"},{"key":"937_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method. Methods. 2001, 25: 402-408. 10.1006\/meth.2001.1262.","journal-title":"Methods"},{"key":"937_CR30","doi-asserted-by":"publisher","first-page":"R39","DOI":"10.1186\/gb-2004-5-6-r39","volume":"5","author":"YM Harcus","year":"2004","unstructured":"Harcus YM, Parkinson J, Fernandez C, Daub J, Selkirk ME, Blaxter ML, Maizels RM: Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites. Genome Biol. 2004, 5: R39-10.1186\/gb-2004-5-6-r39.","journal-title":"Genome Biol"},{"key":"937_CR31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/leu.2012.179","volume":"27","author":"MF Akbari","year":"2013","unstructured":"Akbari MF, Pieters R, den Boer ML: The hunting of targets: challenge in miRNA research. Leukemia. 2013, 27: 16-23. 10.1038\/leu.2012.179.","journal-title":"Leukemia"},{"key":"937_CR32","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.exppara.2012.05.006","volume":"131","author":"O Djurkovic-Djakovic","year":"2012","unstructured":"Djurkovic-Djakovic O, Djokic V, Vujanic M, Zivkovic T, Bobic B, Nikolic A, Slavic K, Klun I, Ivovic V: Kinetics of parasite burdens in blood and tissues during murine toxoplasmosis. Exp Parasitol. 2012, 131: 372-376. 10.1016\/j.exppara.2012.05.006.","journal-title":"Exp Parasitol"},{"key":"937_CR33","doi-asserted-by":"publisher","first-page":"6954","DOI":"10.4049\/jimmunol.172.11.6954","volume":"172","author":"RL Del","year":"2004","unstructured":"Del RL, Butcher BA, Bennouna S, Hieny S, Sher A, Denkers EY: Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors. J Immunol. 2004, 172: 6954-6960.","journal-title":"J Immunol"},{"key":"937_CR34","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1128\/IAI.74.1.135-143.2006","volume":"74","author":"JL Hardison","year":"2006","unstructured":"Hardison JL, Wrightsman RA, Carpenter PM, Kuziel WA, Lane TE, Manning JE: The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006, 74: 135-143. 10.1128\/IAI.74.1.135-143.2006.","journal-title":"Infect Immun"},{"key":"937_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.0105-2896.2004.00174.x","volume":"201","author":"RT Gazzinelli","year":"2004","unstructured":"Gazzinelli RT, Ropert C, Campos MA: Role of the Toll\/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites. Immunol Rev. 2004, 201: 9-25. 10.1111\/j.0105-2896.2004.00174.x.","journal-title":"Immunol Rev"},{"key":"937_CR36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","volume":"201","author":"FD Finkelman","year":"2004","unstructured":"Finkelman FD, Shea-Donohue T, Morris SC, Gildea L, Strait R, Madden KB, Schopf L, Urban JJ: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol Rev. 2004, 201: 139-155. 10.1111\/j.0105-2896.2004.00192.x.","journal-title":"Immunol Rev"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-6-154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-3305-6-154\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-6-154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T08:40:30Z","timestamp":1564562430000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/1756-3305-6-154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,29]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["937"],"URL":"https:\/\/doi.org\/10.1186\/1756-3305-6-154","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,29]]},"article-number":"154"}}