{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:29:01Z","timestamp":1791404941357,"version":"4.3.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Annual community-directed treatment with ivermectin (CDTI) have been carried out since 1999 in the Lekie division (central region of Cameroon where most cases of <jats:italic>Loa<\/jats:italic>-related post ivermectin severe adverse events were reported) as part of the joined activities of the African Programme for Onchocerciasis Control (APOC) and Mectizan\u00ae Donation Program (MDP). As large-scale administration of ivermetine was demonstrated to be an efficient means to control loiasis transmission, it was hypothesized that CDTI would have lowered or halted the transmission of <jats:italic>Loa loa<\/jats:italic> in the Lekie division after 13 years of annual drug administration, indicating a possible reduction in the occurrence of <jats:italic>Loa<\/jats:italic>-related post-ivermectin severe adverse events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A 4-month entomologic study was carried out from March to June 2012 in the Lekie division to evaluate the impact of 13 years of CDTI on the transmission of <jats:italic>L. loa<\/jats:italic> whose baseline data were recorded in 1999\u20132000.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>There was a significant reduction in the infection rate for <jats:italic>Chrysops silacea<\/jats:italic> and <jats:italic>C. dimidiata<\/jats:italic> from 6.8 and 9% in 1999\u20132000 to 3 and 3.6% in 2012, respectively. The differences in the infective rate (IR) (percentage of flies harboring head L3 larvae), potential infective rate (PIR) (percentage of flies bearing L3 larvae), mean head L3 larvae load (MHL3) (average L3 per infective fly) and mean fly L3 larvae load (MFL3) (average L3 per potentially infective fly) for both <jats:italic>C. silacea<\/jats:italic> and <jats:italic>C. dimidiata<\/jats:italic> were not significantly different between the two investigation periods. The biting density (BD) was almost three-fold higher in 2012 for <jats:italic>C. silacea<\/jats:italic> but not for <jats:italic>C. dimidiata<\/jats:italic>. The transmission potential (TP) which is a function of the BD, was higher in the present study than in the baseline investigation for each species.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The infection rate remaining high, the high TP and the stability observed in the IR, PIR, MHL3 and MFL3 after 13 years of CDTI suggest that transmission of <jats:italic>L. loa<\/jats:italic> is still active. This is an indication that the risk of occurrence of severe adverse events such as fatal encephalopathies is still present, especially for heavily microfilaria-loaded people taken ivermectin for the first time.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1756-3305-6-283","type":"journal-article","created":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T21:09:30Z","timestamp":1380316170000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of repeated ivermectin treatments against onchocerciasis on the transmission of loiasis: an entomologic evaluation in central Cameroon"],"prefix":"10.1186","volume":"6","author":[{"given":"Marc K","family":"Kouam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules B","family":"Tchatchueng-Mbougua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Demanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien DS","family":"Pion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kamgno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,9,27]]},"reference":[{"issue":"Suppl 1","key":"1063_CR1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/1475-2883-2-S1-S4","volume":"2","author":"M Boussinesq","year":"2003","unstructured":"Boussinesq M, Gardon J, Gardon-Wendel N, Chippaux JP: Clinical picture, epidemiology and outcome of Loa-associated serious adverse events related to mass ivermectin treatment of onchocerciasis in Cameroon. 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