{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:06:35Z","timestamp":1791173195578,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1756-3305-6-63","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T15:33:28Z","timestamp":1363188808000},"source":"Crossref","is-referenced-by-count":44,"title":["Compound DNA vaccine encoding SAG1\/ SAG3 with A2\/B subunit of cholera toxin as a genetic adjuvant protects BALB\/c mice against Toxoplasma gondii"],"prefix":"10.1186","volume":"6","author":[{"given":"Hua","family":"Cong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"866_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1756-3305-4-165","volume":"4","author":"P Zhou","year":"2011","unstructured":"Zhou P, Chen Z, Li HL, Zheng H, He S, Lin R, Zhu XQ: Toxoplasma gondii infection in humans in China. Parasit Vectors. 2011, 4: 165-10.1186\/1756-3305-4-165.","journal-title":"Parasit Vectors"},{"key":"866_CR2","first-page":"189","volume":"20","author":"R McLeod","year":"2000","unstructured":"McLeod R, Boyer K, Roizen N: The child with congenital toxoplasmosis. Curr Clin Top Infect Dis. 2000, 20: 189-208.","journal-title":"Curr Clin Top Infect Dis"},{"issue":"2","key":"866_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.meegid.2012.01.013","volume":"12","author":"M Vittecoq","year":"2012","unstructured":"Vittecoq M, Elguero E, Lafferty KD, Roche B, Brodeur J, Gauthier-Clerc M, Miss\u00e9 D, Thomas F: Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France. Infect Genet Evol. 2012, 12 (2): 496-498. 10.1016\/j.meegid.2012.01.013.","journal-title":"Infect Genet Evol"},{"key":"866_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1756-3305-6-15","volume":"6","author":"F Walle","year":"2013","unstructured":"Walle F, Kebede N, Tsegaye A, Kassa T: Seroprevalence and risk factors for Toxoplasmosis in HIV infected and non-infected individuals in Bahir Dar. Northwest Ethiopia. Parasit Vectors. 2013, 6: 15-10.1186\/1756-3305-6-15.","journal-title":"Northwest Ethiopia. Parasit Vectors"},{"key":"866_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1017\/S003118200000144X","volume":"110","author":"D Buxton","year":"1995","unstructured":"Buxton D, Innes EA: A commercial vaccine for ovine toxoplasmosis. Parasitol. 1995, 110: 11-16. 10.1017\/S003118200000144X.","journal-title":"Parasitol"},{"issue":"6","key":"866_CR6","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1128\/IAI.61.6.2639-2643.1993","volume":"61","author":"A Lunden","year":"1993","unstructured":"Lunden A, Lovgren K, Ugglaand A, Araujo FG: Immune response and resistance to T. gondii in mice immunized with antigens of the parasite incorporated into immunostimulation complex. Infect Immun. 1993, 61 (6): 2639-","journal-title":"Infect Immun"},{"issue":"5","key":"866_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1550-7408.1996.tb05034.x","volume":"43","author":"CW Angus","year":"1996","unstructured":"Angus CW: Nucleic acid vaccination against Toxoplasma gondii in mice. J Eukaryot Microbiol. 1996, 43 (5): 117-118. 10.1111\/j.1550-7408.1996.tb05034.x.","journal-title":"J Eukaryot Microbiol"},{"issue":"13\u201314","key":"866_CR8","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/S0264-410X(02)00692-8","volume":"21","author":"A Fachado","year":"2003","unstructured":"Fachado A, Rodriguez A, Angel SO: Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice. Vaccine. 2003, 21 (13\u201314): 1327-1335.","journal-title":"Vaccine"},{"key":"866_CR9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/1756-3305-4-213","volume":"4","author":"XM Sun","year":"2011","unstructured":"Sun XM, Zou J, Elashram Saeed AA, Yan WC, Liu XY, Suo X, Wang H, Chen QJ: DNA vaccination with a gene encoding Toxoplasma gondii GRA6 induces partial protection against toxoplasmosis in BALB\/c mice. Parasit Vectors. 2011, 4: 213-10.1186\/1756-3305-4-213.","journal-title":"Parasit Vectors"},{"key":"866_CR10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ijpara.2003.12.004","volume":"34","author":"J Calvin","year":"2004","unstructured":"Calvin J, Cleo Y, Lee F, Michael EG: The SAS superfamily of Toxoplasma surface proteins. Int J Parasitol. 2004, 34: 285-296. 10.1016\/j.ijpara.2003.12.004.","journal-title":"Int J Parasitol"},{"key":"866_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/1756-3305-5-273","volume":"5","author":"M Meng","year":"2012","unstructured":"Meng M, He S, Zhao G, Bai Y, Zhou H, Cong H, Lu G, Zhao Q, Zhu XQ: Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB\/c mice. Parasit Vectors. 2012, 5: 273-10.1186\/1756-3305-5-273.","journal-title":"Parasit Vectors"},{"issue":"36","key":"866_CR12","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1016\/j.vaccine.2005.04.025","volume":"23","author":"MN M\u00e9v\u00e9le","year":"2005","unstructured":"M\u00e9v\u00e9le MN, Bout D, Desolme B: Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice. Vaccine. 2005, 23 (36): 4489-4499. 10.1016\/j.vaccine.2005.04.025.","journal-title":"Vaccine"},{"key":"866_CR13","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1016\/S0264-410X(03)00157-9","volume":"21","author":"MM Rabie","year":"2003","unstructured":"Rabie MM, Fumie A, Mei C: Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes. Vaccine. 2003, 21: 2852-2861. 10.1016\/S0264-410X(03)00157-9.","journal-title":"Vaccine"},{"key":"866_CR14","doi-asserted-by":"crossref","first-page":"16217","DOI":"10.1016\/S0021-9258(17)33995-9","volume":"269","author":"MF Cesbron-Delauw","year":"1994","unstructured":"Cesbron-Delauw MF, Tomavo S, Beauchamps P, Fourmaux MP, Camus D, Capron A, Dubremetz JF: Similarities between the primary structures of two distinct major surface proteins of Toxoplasma gondii. J Biol Chem. 1994, 269: 16217-16222.","journal-title":"J Biol Chem"},{"key":"866_CR15","first-page":"45","volume":"219","author":"S Tomavo","year":"1996","unstructured":"Tomavo S: The major surface proteins of Toxoplasma gondii: structures and functions. Curr Top Microbiol Immunol. 1996, 219: 45-54.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"12","key":"866_CR16","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0020-7519(01)00261-2","volume":"31","author":"C Lekutis","year":"2001","unstructured":"Lekutis C, Ferguson DJ, Grigg ME, Camps M, Boothroyd JC: Surface antigens of Toxoplasma gondii: variations on a theme. Int J Parasitol. 2001, 31 (12): 1285-1292. 10.1016\/S0020-7519(01)00261-2.","journal-title":"Int J Parasitol"},{"key":"866_CR17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1756-3305-6-34","volume":"6","author":"SC Chuang","year":"2013","unstructured":"Chuang SC, Ko JC, Chen CP, Du JT, Yang CD: Induction of long-lasting protective immunity against Toxoplasma gondii in BALB\/c mice by recombinant surface antigen 1 protein encapsulated in poly (lactide-co-glycolide) microparticles. Parasit Vectors. 2013, 6: 34-10.1186\/1756-3305-6-34.","journal-title":"Parasit Vectors"},{"key":"866_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0166-6851(01)00297-3","volume":"116","author":"A Jacquet","year":"2001","unstructured":"Jacquet A, Coulon L, De Neve J, Daminet V, Haumont M, Garcia L, Bollen A, Jurado M, Biemans R: The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteoglycans. Mol Biochem Parasitol. 2001, 116: 35-44. 10.1016\/S0166-6851(01)00297-3.","journal-title":"Mol Biochem Parasitol"},{"key":"866_CR19","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1046\/j.1365-2958.2000.02014.x","volume":"37","author":"F Dzierszinski","year":"2000","unstructured":"Dzierszinski F, Mortuaire M, Cesbron-Delauw MF, Tomavo S: Targeted disruption of the glycosylphosphatidylinositol-anchored surface antigen SAG3 gene in Toxoplasma gondii decreases host cell adhesion and drastically reduces virulence in mice. Mol Microbiol. 2000, 37: 574-582.","journal-title":"Mol Microbiol"},{"key":"866_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1086\/315186","volume":"181","author":"CW Angus","year":"2000","unstructured":"Angus CW, Klivington-Evans D, Dubey JP: Immunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents. Infect Dis. 2000, 181: 317-324. 10.1086\/315186.","journal-title":"Infect Dis"},{"issue":"12","key":"866_CR21","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1128\/IAI.67.12.6358-6363.1999","volume":"67","author":"HV Nielsen","year":"1999","unstructured":"Nielsen HV, Lauemoller SL, Christiansen L, Buus S, Fomsgaard A, Petersen E: Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene. Infect Immun. 1999, 67 (12): 6358-6363.","journal-title":"Infect Immun"},{"issue":"21\u201322","key":"866_CR22","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1016\/S0264-410X(03)00163-4","volume":"21","author":"KN Couper","year":"2003","unstructured":"Couper KN, Nielsen HV, Petersen E, Roberts F, Roberts CW, Alexander J: DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission. Vaccine. 2003, 21 (21\u201322): 2813-2820.","journal-title":"Vaccine"},{"issue":"3","key":"866_CR23","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3349\/ymj.2007.48.3.396","volume":"48","author":"YH Lee","year":"2007","unstructured":"Lee YH, Shin DW, Lee JH, Nam HW, Ahn MH: Vaccination against murine Toxoplasmosis using recombinant Toxoplasma gondii SAG3 antigen alone or in combination with Quil A. Yonsei Med J. 2007, 48 (3): 396-404. 10.3349\/ymj.2007.48.3.396.","journal-title":"Yonsei Med J"},{"issue":"8\u20139","key":"866_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/S0923-2494(98)80144-2","volume":"148","author":"N Lycke","year":"1997","unstructured":"Lycke N: The mechanism of cholera toxin adjuvanticity. Res Immunol. 1997, 148 (8\u20139): 504-","journal-title":"Res Immunol"},{"issue":"4","key":"866_CR25","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1128\/IAI.71.4.1740-1747.2003","volume":"71","author":"K Eriksson","year":"2003","unstructured":"Eriksson K, Fredriksson M, Nordstrom I, Holmgren J: Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development. Infect Immun. 2003, 71 (4): 1740-1747. 10.1128\/IAI.71.4.1740-1747.2003.","journal-title":"Infect Immun"},{"key":"866_CR26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.146.1.286","volume":"146","author":"RT Gazzinelli","year":"1991","unstructured":"Gazzinelli RT, Hakim FT, Hieny S, Shearer GM, Sher A: Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol. 1991, 146: 286-292.","journal-title":"J Immunol"},{"key":"866_CR27","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1016\/j.vaccine.2010.01.031","volume":"28","author":"E Jongert","year":"2010","unstructured":"Jongert E, Lemiere A, Van Ginderachter J, De Craeye S, Huygen K, D\u2019Souza S: Functional characterization of in vivo effector CD4(+) and CD8(+) T cell responses in acute Toxoplasmosis: an interplay of IFN-gamma and cytolytic T cells. Vaccine. 2010, 28: 2556-2564. 10.1016\/j.vaccine.2010.01.031.","journal-title":"Vaccine"},{"issue":"6","key":"866_CR28","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1089\/jir.2005.25.338","volume":"25","author":"X Wang","year":"2005","unstructured":"Wang X, Claflin J, Kang H, Suzuki Y: Importance of CD8(+)Vbeta8(+) T cells in IFN-gamma-mediated prevention of toxoplasmic encephalitis in genetically resistant BALB\/c mice. J Interferon Cytokine Res. 2005, 25 (6): 338-344. 10.1089\/jir.2005.25.338.","journal-title":"J Interferon Cytokine Res"},{"issue":"9","key":"866_CR29","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.placenta.2012.05.013","volume":"33","author":"K Rezende-Oliveira","year":"2012","unstructured":"Rezende-Oliveira K, Silva NM, Mineo JR, Rodrigues JV: Cytokines and chemokines production by mononuclear cells from parturient women after stimulation with live Toxoplasma gondii. Placenta. 2012, 33 (9): 682-687. 10.1016\/j.placenta.2012.05.013.","journal-title":"Placenta"},{"key":"866_CR30","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/1756-3305-4-168","volume":"4","author":"J Zou","year":"2011","unstructured":"Zou J, Huang XX, Yin GW, Ding Y, Liu XY, Wang H, Chen QJ, Suo X: Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts. Parasit Vectors. 2011, 4: 168-10.1186\/1756-3305-4-168.","journal-title":"Parasit Vectors"},{"issue":"5","key":"866_CR31","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s00436-012-3047-y","volume":"111","author":"XN Wu","year":"2012","unstructured":"Wu XN, Lin J, Lin X, Chen J, Chen ZL, Lin JY: Multicomponent DNA vaccine-encoding Toxoplasma gondii GRA1 and SAG1 primes: anti-Toxoplasma immune response in mice. Parasitol Res. 2012, 111 (5): 2001-2009. 10.1007\/s00436-012-3047-y.","journal-title":"Parasitol Res"},{"key":"866_CR32","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/1756-3305-5-186","volume":"5","author":"JL Wang","year":"2012","unstructured":"Wang JL, Liu XL, Jia B, Lu H, Peng S, Piao X, Hou N, Cai P, Yin J, Jiang N, Chen Q: A comparative study of small RNAs in Toxoplasma gondii of distinct genotypes. Parasit Vectors. 2012, 5: 186-10.1186\/1756-3305-5-186.","journal-title":"Parasit Vectors"},{"issue":"12","key":"866_CR33","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1128\/CVI.00397-12","volume":"19","author":"PY Wang","year":"2012","unstructured":"Wang PY, Yuan ZG, Petersen E, Li J, Zhang XX, Li XZ, Li HX, Lv ZC, Cheng T, Ren D, Yang GL, Lin RQ, Zhu XQ: Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice. Clin Vaccine Immunol. 2012, 19 (12): 1916-1920. 10.1128\/CVI.00397-12.","journal-title":"Clin Vaccine Immunol"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-6-63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-3305-6-63\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-6-63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T07:29:35Z","timestamp":1688110175000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/1756-3305-6-63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,13]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["866"],"URL":"https:\/\/doi.org\/10.1186\/1756-3305-6-63","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,13]]},"article-number":"63"}}