{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:30:14Z","timestamp":1790382614703,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1756-3305-7-372","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T23:01:11Z","timestamp":1408143671000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis"],"prefix":"10.1186","volume":"7","author":[{"given":"Yi-hua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-qin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-li","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Rong","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-long","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"1554_CR1","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","volume":"30","author":"AM Tenter","year":"2000","unstructured":"Tenter AM, Heckeroth AR, Weiss LM: Toxoplasma gondii: from animals to humans. Int J Parasitol. 2000, 30: 1217-1258.","journal-title":"Int J Parasitol"},{"key":"1554_CR2","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","volume":"39","author":"LM Weiss","year":"2009","unstructured":"Weiss LM, Dubey JP: Toxoplasmosis: a history of clinical observations. Int J Parasitol. 2009, 39: 895-901.","journal-title":"Int J Parasitol"},{"key":"1554_CR3","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1097\/00002030-199610000-00012","volume":"10","author":"JL Jones","year":"1996","unstructured":"Jones JL, Hanson DL, Chu SY, Ciesielski CA, Kaplan JE, Ward JW, Thomas R: Navin and the Adult\/Adolescent Spectrum of Disease Group: Toxoplasmic encephalitis in HIV-infected persons: risk factors and trends. AIDS. 1996, 10: 1393-1399.","journal-title":"AIDS"},{"key":"1554_CR4","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.1128\/IAI.01042-10","volume":"79","author":"I Dellacasa-Lindberg","year":"2011","unstructured":"Dellacasa-Lindberg I, Fuks JM, Arrighi RBG, Lambert H, Wallin RPA, Chambers BJ, Barragan A: Migratory Activation of Primary Cortical Microglia upon Infection with Toxoplasma gondii. Infect Immun. 2011, 79: 3046-3052.","journal-title":"Infect Immun"},{"key":"1554_CR5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1645\/0022-3395(2000)086[0531:ISCTIE]2.0.CO;2","volume":"86","author":"I Reiter-Owona","year":"2000","unstructured":"Reiter-Owona I, Seitz H, Gross U, Sahm M, Rockstroh JK, Seitz HM: Is stage conversion the initiating event for reactivation of Toxoplasma gondii in brain tissue of AIDS patients?. J Parasitol. 2000, 86: 531-536.","journal-title":"J Parasitol"},{"key":"1554_CR6","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1046\/j.1469-0691.2002.00485.x","volume":"8","author":"D Hill","year":"2002","unstructured":"Hill D, Dubey JP: Toxoplasma gondii: transmission, diagnosis and prevention. Clin Microbiol Infect. 2002, 8: 634-640.","journal-title":"Clin Microbiol Infect"},{"key":"1554_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1742-2094-5-48","volume":"5","author":"G Hermes","year":"2008","unstructured":"Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson DJ, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R: Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J Neuroinflammation. 2008, 5: 48-","journal-title":"J Neuroinflammation"},{"key":"1554_CR8","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.4049\/jimmunol.166.4.2717","volume":"166","author":"H-G Fischer","year":"2001","unstructured":"Fischer H-G, Reichmann G: Brain dendritic cells and macrophages\/microglia in central nervous system inflammation. J Immunol. 2001, 166: 2717-2726.","journal-title":"J Immunol"},{"key":"1554_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/glia.1106","volume":"36","author":"F Aloisi","year":"2001","unstructured":"Aloisi F: Immune function of microglia. Glia. 2001, 36: 165-179.","journal-title":"Glia"},{"key":"1554_CR10","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH: Mechanisms underlying inflammation in neurodegeneration. Cell. 2010, 140: 918-934.","journal-title":"Cell"},{"key":"1554_CR11","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1749-6632.2002.tb04077.x","volume":"962","author":"B Liu","year":"2002","unstructured":"Liu B, Gao HM, Wang JY, Jeohn GH, Cooper CL, Hong JS: Role of nitric oxide in inflammation-mediated neurodegeneration. Ann N Y Acad Sci. 2002, 962: 318-331.","journal-title":"Ann N Y Acad Sci"},{"key":"1554_CR12","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.chom.2011.04.015","volume":"9","author":"KD Jensen","year":"2011","unstructured":"Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP: Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host Microbe. 2011, 9: 472-483.","journal-title":"Cell Host Microbe"},{"key":"1554_CR13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.nurt.2010.07.002","volume":"7","author":"DJ Loane","year":"2010","unstructured":"Loane DJ, Byrnes KR: Role of microglia in neurotrauma. Neurotherapeutics. 2010, 7: 366-377.","journal-title":"Neurotherapeutics"},{"key":"1554_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1742-2094-7-41","volume":"7","author":"K Dohi","year":"2010","unstructured":"Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T: Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation. 2010, 7: 41-","journal-title":"J Neuroinflammation"},{"key":"1554_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1742-2094-9-46","volume":"9","author":"S Lin","year":"2012","unstructured":"Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW: Heme activates TLR4-mediated inflammatory injury via MyD88\/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation. 2012, 9: 46-","journal-title":"J Neuroinflammation"},{"key":"1554_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12640-009-9045-x","volume":"16","author":"M Liu","year":"2009","unstructured":"Liu M, Cai T, Zhao F, Zheng G, Wang Q, Chen Y, Huang C, Luo W, Chen J: Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism. Neurotox Res. 2009, 16: 42-49.","journal-title":"Neurotox Res"},{"key":"1554_CR17","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.2353\/ajpath.2008.080483","volume":"173","author":"G Ramesh","year":"2008","unstructured":"Ramesh G, Borda JT, Dufour J, Kaushal D, Ramamoorthy R, Lackner AA, Philipp MT: Interaction of the Lyme disease Spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis. Am J Pathol. 2008, 173: 1415-1427.","journal-title":"Am J Pathol"},{"key":"1554_CR18","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.4049\/jimmunol.179.2.1129","volume":"179","author":"F Debierre-Grockiego","year":"2007","unstructured":"Debierre-Grockiego F, Campos MA, Azzouz N, Schmidt J, Bieker U, Resende MG, Mansur DS, Weingart R, Schmidt RR, Golenbock DT, Gazzinelli RT, Schwarz RT: Activation of TLR2 and TLR4 by glycosylphosphatidy- linositols derived from Toxoplasma gondii. J Immunol. 2007, 179: 1129-1137.","journal-title":"J Immunol"},{"key":"1554_CR19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.chom.2011.05.010","volume":"9","author":"PJ Murray","year":"2011","unstructured":"Murray PJ: Macrophages as a battleground for toxoplasma pathogenesis. Cell Host Micro-be. 2011, 9: 445-447.","journal-title":"Cell Host Micro-be"},{"key":"1554_CR20","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1242\/jcs.02934","volume":"119","author":"L Kim","year":"2006","unstructured":"Kim L, Denkers EY: Toxoplasma gondii triggers Gi-dependent PI3-kinase signaling required for inhibition of host cell apoptosis. J Cell Sci. 2006, 119: 2119-2126.","journal-title":"J Cell Sci"},{"key":"1554_CR21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1365-3024.2007.00956.x","volume":"29","author":"Y Nishikawa","year":"2007","unstructured":"Nishikawa Y, Kawase O, Vielemeyer O, Suzuki H, Joiner KA, Xuan X, Nagasawa H: Toxoplasma gondii infection induces apoptosis in non- infected macrophages: role of nitric oxide and othersoluble factors. Parasite Immunol. 2007, 29: 375-385.","journal-title":"Parasite Immunol"},{"key":"1554_CR22","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1128\/iai.61.10.4038-4044.1993","volume":"61","author":"CA Hunter","year":"1993","unstructured":"Hunter CA, Abrams JS, Beaman MH, Remington JS: Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii. Infect Immun. 1993, 61: 4038-4044.","journal-title":"Infect Immun"},{"key":"1554_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3109\/13550280009006381","volume":"6","author":"M Nebuloni","year":"2000","unstructured":"Nebuloni M, Pellegrinelli A, Ferri A, Tosoni A, Bonetto S, Zerbi P, Boldorini R, Vago L, Costanzi G: Etiology of microglial nodules in brains of patients with acquired immunodeficiency syndrome. J Neurovirol. 2000, 6: 46-50.","journal-title":"J Neurovirol"},{"key":"1554_CR24","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.vetpar.2011.06.013","volume":"183","author":"ZW Chen","year":"2011","unstructured":"Chen ZW, Gao JM, Huo XX, Wang L, Yu L, Halm-Lai F, Xu YH, Song WJ, Hide G, Shen JL, Lun ZR: Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China. Vet Parasitol. 2011, 183: 166-170.","journal-title":"Vet Parasitol"},{"key":"1554_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.arcmed.2009.04.003","volume":"40","author":"Y Wang","year":"2009","unstructured":"Wang Y, Meng Q, Qiao H, Jiang H, Sun X: Role of the spleen in cyclophosphamide-induced hematosuppression and extramedullary hemato- poiesis in mice. Arch Med Res. 2009, 40: 249-255.","journal-title":"Arch Med Res"},{"key":"1554_CR26","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s004360050185","volume":"82","author":"MH Sumyuen","year":"1996","unstructured":"Sumyuen MH, Garin YJ, Derouin F: Effect of immunosuppressive drug regimens on acute and chronic murine toxoplasmosis. Parasitol Res. 1996, 82: 681-686.","journal-title":"Parasitol Res"},{"key":"1554_CR27","doi-asserted-by":"publisher","first-page":"e9205","DOI":"10.1371\/journal.pone.0009205","volume":"5","author":"L Chen","year":"2010","unstructured":"Chen L, Shi W, Li H, Sun X, Fan X, Lesage G, Li H, Li Y, Zhang Y, Zhang X, Zhang Y, Yin D: Critical role of toll-like receptor 9 in morphine and My- cobacterium tuberculosis-induced apoptosis in mice. PLoS One. 2010, 5: e9205-","journal-title":"PLoS One"},{"key":"1554_CR28","first-page":"1","volume":"58","author":"JE Kaplan","year":"2009","unstructured":"Kaplan JE, Benson C, Holmes KH, Brooks JT, Pau A, Masur H: Guidelines for prevention and treatment of opportunistic infections in HIV- infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep. 2009, 58: 1-207.","journal-title":"MMWR Recomm Rep"},{"key":"1554_CR29","first-page":"1687","volume":"17","author":"K Liang","year":"2011","unstructured":"Liang K, Jiang Z, Ding BQ, Cheng P, Huang DK, Tao LM: Expression of cell proliferation and apoptosis biomarkers in pterygia and normal conjunctiva. Mol Vis. 2011, 17: 1687-1693.","journal-title":"Mol Vis"},{"key":"1554_CR30","doi-asserted-by":"publisher","first-page":"e23059","DOI":"10.1371\/journal.pone.0023059","volume":"6","author":"GH Zhang","year":"2011","unstructured":"Zhang GH, Lv MM, Wang S, Chen L, Qian NS, Tang Y, Zhang XD, Ren PC, Gao CJ, Sun XD, Xu LX: Spinal astrocytic activation is involved in a virally- induced rat model of neuropathic pain. PLoS One. 2011, 6: e23059-","journal-title":"PLoS One"},{"issue":"1","key":"1554_CR31","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ajpath.2012.03.029","volume":"181","author":"U1 H\u00e4ndel","year":"2012","unstructured":"H\u00e4ndel U1, Brunn A, Dr\u00f6gem\u00fcller K, M\u00fcller W, Deckert M, Schl\u00fcter D: Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murineToxoplasma encephalitis. Am J Pathol. 2012, 181 (1): 163-173.","journal-title":"Am J Pathol"},{"key":"1554_CR32","first-page":"488","volume":"13","author":"C Davis","year":"2012","unstructured":"Davis C, Manteuffel J: Unusual presentation of Toxoplasma gondii encephalitis. West J Emerg Med. 2012, 13: 488-490.","journal-title":"West J Emerg Med"},{"key":"1554_CR33","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s004360050311","volume":"83","author":"HG Fischer","year":"1997","unstructured":"Fischer HG, Nitzgen B, Reichmann G, Gross U, Hadding U: Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain. Parasitol Res. 1997, 83: 637-641.","journal-title":"Parasitol Res"},{"key":"1554_CR34","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/1756-3305-6-356","volume":"6","author":"Y Cai","year":"2013","unstructured":"Cai Y, Chen H, Jin L, You Y, Shen JL: STAT3-dependent transactivation of miRNA genes following Toxoplasma gondii infection in macrophage. Parasit Vectors. 2013, 6: 356-","journal-title":"Parasit Vectors"},{"key":"1554_CR35","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1128\/IAI.06295-11","volume":"80","author":"X Xu","year":"2012","unstructured":"Xu X, Liu T, Zhang A, Huo X, Luo Q, Chen Z, Yu L, Li Q, Liu L, Lun ZR, Shen J: Reactive oxygen species-triggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12, CHOP, and the JNK pathway in Toxoplasma gondii infection in mice. Infect Immun. 2012, 80: 2121-2132.","journal-title":"Infect Immun"},{"key":"1554_CR36","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/1756-3305-6-308","volume":"6","author":"AM Zhang","year":"2013","unstructured":"Zhang AM, Shen Q, Li M, Xu XC, Chen H, Cai YH, Luo QL, Chu DY, Yu L, Du J, Lun ZR, Wang Y, Sha Q, Shen JL: Comparative studies of acrophage-biased responses in mice to infection with Toxoplasma gondii ToxoDB #9 strains of different virulence isolated from China. Parasit Vectors. 2013, 6: 308-","journal-title":"Parasit Vectors"},{"key":"1554_CR37","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/glia.20474","volume":"55","author":"A Ghoshal","year":"2007","unstructured":"Ghoshal A, Das S, Ghosh S, Mishra MK, Sharma V, Koli P, Sen E, Basu A: Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia. 2007, 55: 483-496.","journal-title":"Glia"},{"key":"1554_CR38","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.micinf.2007.06.003","volume":"9","author":"I Dellacasa-Lindberg","year":"2007","unstructured":"Dellacasa-Lindberg I, Hitziger N, Barragan A: Localized recrudescence of Toxoplasma infections in the central nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging. Microbes Infect. 2007, 9: 1291-1298.","journal-title":"Microbes Infect"},{"issue":"12","key":"1554_CR39","doi-asserted-by":"publisher","first-page":"e28925","DOI":"10.1371\/journal.pone.0028925","volume":"6","author":"M Berenreiterova","year":"2011","unstructured":"Berenreiterova M, Flegr J, Kube NAAA, Nemec P: The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent Toxoplasmosis: implications for the behavioral manipulation hypothesis. PLoS One. 2011, 6 (12): e28925-","journal-title":"PLoS One"},{"key":"1554_CR40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/MPH.0b013e318257a15c","volume":"34","author":"D Caselli","year":"2012","unstructured":"Caselli D, Andreoli E, Paolicchi O, Savelli S, Guidi S, Pecile P, Aric\u00f2 M: Acute encephalopathy in the immune-compromised child: never forget toxo- plasmosis. J Pediatr Hematol Oncol. 2012, 34: 383-386.","journal-title":"J Pediatr Hematol Oncol"},{"key":"1554_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/jcbfm.2009.194","volume":"30","author":"M Tang","year":"2010","unstructured":"Tang M, Alexander H, Clark RS, Kochanek PM, Kagan VE, Bayir H: Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. J Cereb Blood Flow Metab. 2010, 30: 119-129.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1554_CR42","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.nbd.2012.02.006","volume":"46","author":"J Abraham","year":"2012","unstructured":"Abraham J, Fox PD, Condello C, Bartolini A, Koh S: Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures. Neurobiol Dis. 2012, 46: 425-430.","journal-title":"Neurobiol Dis"},{"key":"1554_CR43","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1742-2094-5-15","volume":"5","author":"CJ Henry","year":"2008","unstructured":"Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, Sheridan JF, Godbout JP: Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation. 2008, 5: 15-","journal-title":"J Neuroinflammation"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-7-372.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T05:29:18Z","timestamp":1630560558000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/1756-3305-7-372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,15]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1186\/1756-3305-7-372","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,15]]},"assertion":[{"value":"13 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"372"}}