{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:35:04Z","timestamp":1761489304625},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1756-3305-7-43","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T18:22:44Z","timestamp":1390414964000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae"],"prefix":"10.1186","volume":"7","author":[{"given":"Sridhar","family":"Arumugam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lustigman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R","family":"Klei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"issue":"3","key":"1195_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1128\/CMR.00002-13","volume":"26","author":"CP Morris","year":"2013","unstructured":"Morris CP, Evans H, Larsen S, Mitre E: A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. Clin Microbiol Rev. 2013, 26 (3): 381-421. 10.1128\/CMR.00002-13.","journal-title":"Clin Microbiol Rev"},{"key":"1195_CR2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nri1183","volume":"3","author":"RM Maizels","year":"2003","unstructured":"Maizels RM, Yazdanbakhsh M: Regulation of the immune response by helminth parasites: cellular and molecular mechanisms. Nat Rev Immunol. 2003, 3: 733-743. 10.1038\/nri1183.","journal-title":"Nat Rev Immunol"},{"key":"1195_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","volume":"201","author":"RM Maizels","year":"2004","unstructured":"Maizels RM, Balic A, Gomez-Escobar N, Nair M, Taylor M, Allen JE: Helminth parasites: masters of regulation. Immunol Rev. 2004, 201: 89-116. 10.1111\/j.0105-2896.2004.00191.x.","journal-title":"Immunol Rev"},{"key":"1195_CR4","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1086\/593701","volume":"175","author":"E Sartono","year":"1997","unstructured":"Sartono E, Kruize YCM, Kurniawan-Atmadja A, Maizels RM, Yazdanbakhsh M: Depression of antigen-specific interleukin-5 and interferon-g responses in human lymphatic filariasis as a function of clinical status and age. J Infect Dis. 1997, 175: 1276-1280. 10.1086\/593701.","journal-title":"J Infect Dis"},{"key":"1195_CR5","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.4049\/jimmunol.176.5.3248","volume":"176","author":"S Babu","year":"2006","unstructured":"Babu S, Blauvelt CP, Kumaraswami V, Nutman TB: Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. J Immunol. 2006, 176: 3248-3256.","journal-title":"J Immunol"},{"key":"1195_CR6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4049\/jimmunol.129.1.338","volume":"129","author":"NA Kaushal","year":"1982","unstructured":"Kaushal NA, Hussain R, Nash TE, Ottesen E: Identification and characterization of excretory-secretory products of Brugia malayi, adult filarial parasites. J Immunol. 1982, 129: 338-343.","journal-title":"J Immunol"},{"issue":"1","key":"1195_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","volume":"167","author":"JP Hewitson","year":"2009","unstructured":"Hewitson JP, Grainger JR, Maizels RM: Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Mol Biochem Parasitol. 2009, 167 (1): 1-11. 10.1016\/j.molbiopara.2009.04.008.","journal-title":"Mol Biochem Parasitol"},{"issue":"1","key":"1195_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","volume":"160","author":"JP Hewitson","year":"2008","unstructured":"Hewitson JP, Harcus YM, Curwen RS, Dowle AA, Atmadja AK, Ashton PD, Wilson A, Maizels RM: The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products. Mol Biochem Parasitol. 2008, 160 (1): 8-21. 10.1016\/j.molbiopara.2008.02.007.","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"1195_CR9","doi-asserted-by":"publisher","first-page":"e410","DOI":"10.1371\/journal.pntd.0000410","volume":"3","author":"S Bennuru","year":"2009","unstructured":"Bennuru S, Semnani R, Meng Z, Ribeiro JM, Veenstra TD, Nutman TB: Brugia malayi excreted\/secreted proteins at the host\/parasite interface: stage- and gender-specific proteomic profiling. PLoS Negl Trop Dis. 2009, 3 (4): e410-10.1371\/journal.pntd.0000410.","journal-title":"PLoS Negl Trop Dis"},{"issue":"6\u20137","key":"1195_CR10","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.biocel.2007.11.012","volume":"40","author":"WF Gregory","year":"2008","unstructured":"Gregory WF, Maizels RM: Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. Int J Biochem Cell Biol. 2008, 40 (6\u20137): 1389-1398.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"1195_CR11","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11882-007-0031-1","volume":"7","author":"MF de Macedo Soares","year":"2007","unstructured":"de Macedo Soares MF, de Macedo MS: Modulation of anaphylaxis by helminth-derived products in animal models. Curr Allergy Asthma Rep. 2007, 7 (1): 56-61. 10.1007\/s11882-007-0031-1.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"2","key":"1195_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molbiopara.2004.11.008","volume":"139","author":"J Murray","year":"2005","unstructured":"Murray J, Manoury B, Balic A, Watts C, Maizels RM: Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Mol Biochem Parasitol. 2005, 139 (2): 197-203. 10.1016\/j.molbiopara.2004.11.008.","journal-title":"Mol Biochem Parasitol"},{"issue":"6","key":"1195_CR13","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0960-9822(01)00118-X","volume":"11","author":"B Manoury","year":"2001","unstructured":"Manoury B, Gregory WF, Maizels RM, Watts C: Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr Biol. 2001, 11 (6): 447-451. 10.1016\/S0960-9822(01)00118-X.","journal-title":"Curr Biol"},{"issue":"24","key":"1195_CR14","doi-asserted-by":"crossref","first-page":"17339","DOI":"10.1016\/S0021-9258(18)41931-X","volume":"267","author":"S Lustigman","year":"1992","unstructured":"Lustigman S, Brotman B, Huima T, Prince AM, McKerrow JH: Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J Biol Chem. 1992, 267 (24): 17339-17346.","journal-title":"J Biol Chem"},{"issue":"1","key":"1195_CR15","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1128\/IAI.69.1.262-270.2001","volume":"69","author":"D Abraham","year":"2001","unstructured":"Abraham D, Leon O, Leon S, Lustigman S: Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus. Infect Immun. 2001, 69 (1): 262-270. 10.1128\/IAI.69.1.262-270.2001.","journal-title":"Infect Immun"},{"issue":"3","key":"1195_CR16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1471-4922(01)02211-5","volume":"18","author":"S Lustigman","year":"2002","unstructured":"Lustigman S, James ER, Tawe W, Abraham D: Towards a recombinant antigen vaccine against Onchocerca volvulus. Trends Parasitol. 2002, 18 (3): 135-141. 10.1016\/S1471-4922(01)02211-5.","journal-title":"Trends Parasitol"},{"issue":"8","key":"1195_CR17","doi-asserted-by":"publisher","first-page":"e800","DOI":"10.1371\/journal.pntd.0000800","volume":"4","author":"F Cho-Ngwa","year":"2010","unstructured":"Cho-Ngwa F, Liu J, Lustigman S: The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age. PLoS Negl Trop Dis. 2010, 4 (8): e800-10.1371\/journal.pntd.0000800.","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"1195_CR18","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0020-7519(01)00350-2","volume":"32","author":"AW Pfaff","year":"2002","unstructured":"Pfaff AW, Schulz-Key H, Soboslay PT, Taylor DW, MacLennan K, Hoffmann WH: Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis. Int J Parasitol. 2002, 32 (2): 171-178. 10.1016\/S0020-7519(01)00350-2.","journal-title":"Int J Parasitol"},{"issue":"12","key":"1195_CR19","doi-asserted-by":"publisher","first-page":"e1968","DOI":"10.1371\/journal.pntd.0001968","volume":"6","author":"SA Babayan","year":"2012","unstructured":"Babayan SA, Luo H, Gray N, Taylor DW, Allen JE: Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes. PLoS Negl Trop Dis. 2012, 6 (12): e1968-10.1371\/journal.pntd.0001968.","journal-title":"PLoS Negl Trop Dis"},{"key":"1195_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0166-6851(01)00453-4","volume":"120","author":"B Zhan","year":"2002","unstructured":"Zhan B, Hotez JP, Wang Y, Hawdon MJ: A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of protease. Mol Biochem Parasitol. 2002, 120: 291-296. 10.1016\/S0166-6851(01)00453-4.","journal-title":"Mol Biochem Parasitol"},{"key":"1195_CR21","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0014-4894(90)90065-K","volume":"71","author":"TR Klei","year":"1990","unstructured":"Klei TR, McVay CS, Dennis VA, Coleman SU, Enright FM, Casey HW: Brugia pahangi: Effects of duration of infection and parasite burden on lymphatic lesion severity, granulomatous hypersensitivity, and immune responses in jirds (Meriones unguiculatus). Exp Parasitol. 1990, 71: 393-405. 10.1016\/0014-4894(90)90065-K.","journal-title":"Exp Parasitol"},{"issue":"1","key":"1195_CR22","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1645\/GE-599R.1","volume":"92","author":"SR Chirgwin","year":"2006","unstructured":"Chirgwin SR, Coleman S, Porthouse KH, Klei TR: Tissue migration capability of larval and adult Brugia pahangi. J Parasitol. 2006, 92 (1): 46-51. 10.1645\/GE-599R.1.","journal-title":"J Parasitol"},{"key":"1195_CR23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/9781118393321.ch28","volume-title":"Current approaches to the development of a vaccine against filarial nematodes, in immunity to parasitic infection","author":"S Lustigman","year":"2012","unstructured":"Lustigman S: Current approaches to the development of a vaccine against filarial nematodes, in immunity to parasitic infection. Edited by: Lamb TJ. 2012, John Wiley & Sons, Ltd: Chichester, UK, 459-470. Chapter 28: doi: 10.1002\/9781118393321.ch28"},{"key":"1195_CR24","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1128\/IAI.74.4.2366-2372.2006","volume":"74","author":"KH Porthouse","year":"2006","unstructured":"Porthouse KH, Chirgwin SR, Coleman S, Taylor HW, Klei T: Inflammatory responses to migrating Brugia pahangi third-stage larvae. Infect Immun. 2006, 74: 2366-2372. 10.1128\/IAI.74.4.2366-2372.2006.","journal-title":"Infect Immun"},{"issue":"2","key":"1195_CR25","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.exppara.2013.08.007","volume":"135","author":"GR Zipperer","year":"2013","unstructured":"Zipperer GR, Arumugam S, Chirgwin SR, Coleman SU, Shakya KP, Klei TR: Brugia pahangi: Immunization with early L3 ES alters parasite migration, fecundity and lymphatic lesion formation in gerbils (Meriones unguiculatus). Exp Parasitol. 2013, 135 (2): 446-455. 10.1016\/j.exppara.2013.08.007.","journal-title":"Exp Parasitol"},{"issue":"4","key":"1195_CR26","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1645\/0022-3395(2002)088[0684:EOVWRF]2.0.CO;2","volume":"88","author":"PJ Hotez","year":"2002","unstructured":"Hotez PJ, Ashcom J, Bin Z, Bethony J, Williamson A, Hawdon JM, Jianjun F, Dobardzic A, Rizo I, Bolden J, Jin Q, Yan W, Dobardzic R, Chung-Debose S, Crowell M, Datu B, Delaney A, Dragonovski D, Jiang Y, Yueyuan L, Ghosh K, Loukas A, Brandt W, Russell PK, Zook BC: Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine. J Parasitol. 2002, 88 (4): 684-690.","journal-title":"J Parasitol"},{"key":"1195_CR27","first-page":"149","volume-title":"Cues that influence behavior of internal parasites","author":"RT Damian","year":"1982","unstructured":"Damian RT: The influence of host immune responses on parasite behavior. Cues that influence behavior of internal parasites. Edited by: Bailey WS. 1982, Agricultural Research Service (Southern Region), U.S: Department of Agriculture, 149-165."}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-7-43.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T23:51:24Z","timestamp":1688946684000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/1756-3305-7-43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1195"],"URL":"https:\/\/doi.org\/10.1186\/1756-3305-7-43","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]},"assertion":[{"value":"20 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"43"}}