{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:27:03Z","timestamp":1789900023460,"version":"4.0.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1756-3305-7-433","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T15:01:54Z","timestamp":1410188514000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Plasma microRNAs are promising novel biomarkers for the early detection of Toxoplasma gondii infection"],"prefix":"10.1186","volume":"7","author":[{"given":"Boyin","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"1645_CR1","first-page":"101","volume-title":"Toxoplasma, Hammondia, Besnotia, Sarcosystis, and Other Tissue Cyst-Forming Coccidia of Man and Animals","author":"J Dubey","year":"1977","unstructured":"Dubey J: Toxoplasma, Hammondia, Besnotia, Sarcosystis, and Other Tissue Cyst-Forming Coccidia of Man and Animals. 1977, New York: Academic Press, 3: 101-237."},{"key":"1645_CR2","first-page":"220","volume-title":"Toxoplasmosis of Animals and Man","author":"J Dubey","year":"1988","unstructured":"Dubey J, Beattie C: Toxoplasmosis of Animals and Man. 1988, Boca Raton: CRC Press, 220-"},{"issue":"1","key":"1645_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/1756-3305-6-241","volume":"6","author":"X Sun","year":"2013","unstructured":"Sun X, Lu H, Jia B, Chang Z, Peng S, Yin J, Chen Q, Jiang N: A comparative study of Toxoplasma gondii seroprevalence in three healthy Chinese populations detected using native and recombinant antigens. Parasit Vectors. 2013, 6 (1): 241-","journal-title":"Parasit Vectors"},{"key":"1645_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1756-3305-5-141","volume":"5","author":"CK Fan","year":"2012","unstructured":"Fan CK, Lee LW, Liao CW, Huang YC, Lee YL, Chang YT, da Costa Ados S, Gil V, Chi LH, Nara T: Toxoplasma gondii infection: relationship between seroprevalence and risk factors among primary schoolchildren in the capital areas of Democratic Republic of Sao Tome and Principe, West Africa. Parasit Vectors. 2012, 5: 141-","journal-title":"Parasit Vectors"},{"issue":"7","key":"1645_CR5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1097\/INF.0b013e3182129e70","volume":"30","author":"A Sauer","year":"2011","unstructured":"Sauer A, de la Torre A, Gomez-Marin J, Bourcier T, Garweg J, Speeg-Schatz C, Candolfi E: Prevention of retinochoroiditis in congenital toxoplasmosis: Europe versus South America. Pediatr Infect Dis J. 2011, 30 (7): 601-603.","journal-title":"Pediatr Infect Dis J"},{"issue":"5","key":"1645_CR6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0248-8663(98)80100-8","volume":"19","author":"P Bossi","year":"1998","unstructured":"Bossi P, Caumes E, Astagneau P, Li TS, Paris L, Mengual X, Katlama C, Bricaire F: Epidemiologic characteristics of cerebral toxoplasmosis in 399 HIV-infected patients followed between 1983 and 1994. Rev Med Interne. 1998, 19 (5): 313-317.","journal-title":"Rev Med Interne"},{"issue":"2","key":"1645_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1017\/S0031182011001880","volume":"139","author":"XJ Gao","year":"2012","unstructured":"Gao XJ, Zhao ZJ, He ZH, Wang T, Yang TB, Chen XG, Shen JL, Wang Y, Lv FL, Hide G, Lun ZR: Toxoplasma gondii infection in pregnant women in China. Parasitology. 2012, 139 (2): 139-147.","journal-title":"Parasitology"},{"issue":"3","key":"1645_CR8","first-page":"451","volume":"65","author":"G Karczewski","year":"2011","unstructured":"Karczewski G, Golab E: Diagnostic problems with congenital toxoplasmosis. Przegl Epidemiol. 2011, 65 (3): 451-454.","journal-title":"Przegl Epidemiol"},{"issue":"2","key":"1645_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1590\/S0074-02762009000200026","volume":"104","author":"R Gilbert","year":"2009","unstructured":"Gilbert R: Treatment for congenital toxoplasmosis: finding out what works. Mem Inst Oswaldo Cruz. 2009, 104 (2): 305-311.","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1\u20132","key":"1645_CR10","first-page":"45","volume":"50","author":"C Contini","year":"2008","unstructured":"Contini C: Clinical and diagnostic management of toxoplasmosis in the immunocompromised patient. Parassitologia. 2008, 50 (1\u20132): 45-50.","journal-title":"Parassitologia"},{"issue":"6","key":"1645_CR11","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/j.1469-0691.2006.01444.x","volume":"12","author":"A Sensini","year":"2006","unstructured":"Sensini A: Toxoplasma gondii infection in pregnancy: opportunities and pitfalls of serological diagnosis. Clin Microbiol Infect. 2006, 12 (6): 504-512.","journal-title":"Clin Microbiol Infect"},{"issue":"11","key":"1645_CR12","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/JCM.38.11.4121-4125.2000","volume":"38","author":"MH Lin","year":"2000","unstructured":"Lin MH, Chen TC, Kuo TT, Tseng CC, Tseng CP: Real-time PCR for quantitative detection of Toxoplasma gondii. J Clin Microbiol. 2000, 38 (11): 4121-4125.","journal-title":"J Clin Microbiol"},{"key":"1645_CR13","first-page":"195","volume":"92","author":"T Toth","year":"1998","unstructured":"Toth T, Sziller I, Papp Z: PCR detection of Toxoplasma gondii in human fetal tissues. Methods Mol Biol. 1998, 92: 195-202.","journal-title":"Methods Mol Biol"},{"issue":"10","key":"1645_CR14","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/BF01701532","volume":"15","author":"EC Guy","year":"1996","unstructured":"Guy EC, Pelloux H, Lappalainen M, Aspock H, Hassl A, Melby KK, Holberg-Pettersen M, Petersen E, Simon J, Ambroise-Thomas P: Interlaboratory comparison of polymerase chain reaction for the detection of Toxoplasma gondii DNA added to samples of amniotic fluid. Eur J Clin Microbiol Infect Dis. 1996, 15 (10): 836-839.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"9","key":"1645_CR15","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1161\/CIRCRESAHA.108.183426","volume":"103","author":"E Van Rooij","year":"2008","unstructured":"Van Rooij E, Marshall WS, Olson EN: Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res. 2008, 103 (9): 919-928.","journal-title":"Circ Res"},{"issue":"9","key":"1645_CR16","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1017\/S003118201300053X","volume":"140","author":"MJ Xu","year":"2013","unstructured":"Xu MJ, Zhou DH, Huang SY, Zhao FR, Nisbet AJ, Lin RQ, Song HQ, Zhu XQ: Comparative characterization of microRNA profiles of different genotypes of Toxoplasma gondii. Parasitology. 2013, 140 (9): 1111-1118.","journal-title":"Parasitology"},{"key":"1645_CR17","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/1756-3305-5-186","volume":"5","author":"J Wang","year":"2012","unstructured":"Wang J, Liu X, Jia B, Lu H, Peng S, Piao X, Hou N, Cai P, Yin J, Jiang N, Chen Q: A comparative study of small RNAs in Toxoplasma gondii of distinct genotypes. Parasit Vectors. 2012, 5: 186-","journal-title":"Parasit Vectors"},{"issue":"1","key":"1645_CR18","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1756-3305-6-154","volume":"6","author":"MJ Xu","year":"2013","unstructured":"Xu MJ, Zhou DH, Nisbet AJ, Huang SY, Fan YF, Zhu XQ: Characterization of mouse brain microRNAs after infection with cyst-forming Toxoplasma gondii. Parasit Vectors. 2013, 6 (1): 154-","journal-title":"Parasit Vectors"},{"key":"1645_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neuroscience.2014.03.015","volume":"268","author":"J Xiao","year":"2014","unstructured":"Xiao J, Li Y, Prandovszky E, Karuppagounder SS, Talbot CC, Dawson VL, Dawson TM, Yolken RH: MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience. 2014, 268: 128-138.","journal-title":"Neuroscience"},{"key":"1645_CR20","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/1756-3305-6-356","volume":"6","author":"Y Cai","year":"2013","unstructured":"Cai Y, Chen H, Jin L, You Y, Shen J: STAT3-dependent transactivation of miRNA genes following Toxoplasma gondii infection in macrophage. Parasit Vectors. 2013, 6: 356-","journal-title":"Parasit Vectors"},{"issue":"30","key":"1645_CR21","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008, 105 (30): 10513-10518.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"1645_CR22","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1136\/gut.2008.167817","volume":"58","author":"EK Ng","year":"2009","unstructured":"Ng EK, Chong WW, Jin H, Lam EK, Shin VY, Yu J, Poon TC, Ng SS, Sung JJ: Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut. 2009, 58 (10): 1375-1381.","journal-title":"Gut"},{"issue":"3","key":"1645_CR23","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1183\/09031936.00029610","volume":"37","author":"J Silva","year":"2011","unstructured":"Silva J, Garcia V, Zaballos A, Provencio M, Lombardia L, Almonacid L, Garcia JM, Dominguez G, Pena C, Diaz R, Herrera M, Varela A, Bonilla F: Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur Respir J. 2011, 37 (3): 617-623.","journal-title":"Eur Respir J"},{"issue":"11","key":"1645_CR24","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1038\/bjc.2011.453","volume":"105","author":"R Morimura","year":"2011","unstructured":"Morimura R, Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Nagata H, Konishi H, Shiozaki A, Ikoma H, Okamoto K, Ochiai T, Taniguchi H, Otsuji E: Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer. Br J Cancer. 2011, 105 (11): 1733-1740.","journal-title":"Br J Cancer"},{"issue":"13","key":"1645_CR25","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1002\/pros.22499","volume":"72","author":"J Shen","year":"2012","unstructured":"Shen J, Hruby GW, McKiernan JM, Gurvich I, Lipsky MJ, Benson MC, Santella RM: Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer. Prostate. 2012, 72 (13): 1469-1477.","journal-title":"Prostate"},{"issue":"5","key":"1645_CR26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/(SICI)1098-1004(1998)11:5<404::AID-HUMU8>3.0.CO;2-S","volume":"11","author":"M Caggana","year":"1998","unstructured":"Caggana M, Conroy JM, Pass KA: Rapid, efficient method for multiplex amplification from filter paper. Hum Mutat. 1998, 11 (5): 404-409.","journal-title":"Hum Mutat"},{"issue":"1","key":"1645_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0020-7519(99)00170-8","volume":"30","author":"WL Homan","year":"2000","unstructured":"Homan WL, Vercammen M, De Braekeleer J, Verschueren H: Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int J Parasitol. 2000, 30 (1): 69-75.","journal-title":"Int J Parasitol"},{"issue":"3","key":"1645_CR28","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","volume":"245","author":"J Ozer","year":"2008","unstructured":"Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S: The current state of serum biomarkers of hepatotoxicity. Toxicology. 2008, 245 (3): 194-205.","journal-title":"Toxicology"},{"issue":"10","key":"1645_CR29","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1373\/clinchem.2005.049908","volume":"51","author":"DE Amacher","year":"2005","unstructured":"Amacher DE, Adler R, Herath A, Townsend RR: Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. Clin Chem. 2005, 51 (10): 1796-1803.","journal-title":"Clin Chem"},{"issue":"5","key":"1645_CR30","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1161\/CIRCRESAHA.109.215566","volume":"107","author":"S Fichtlscherer","year":"2010","unstructured":"Fichtlscherer S, De Rosa S, Fox H, Schwietz T, Fischer A, Liebetrau C, Weber M, Hamm CW, Roxe T, Muller-Ardogan M, Bonauer A, Zeiher AM, Dimmeler S: Circulating microRNAs in patients with coronary artery disease. Circ Res. 2010, 107 (5): 677-684.","journal-title":"Circ Res"},{"issue":"5","key":"1645_CR31","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","volume":"141","author":"CH Lawrie","year":"2008","unstructured":"Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL: Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008, 141 (5): 672-675.","journal-title":"Br J Haematol"},{"issue":"6","key":"1645_CR32","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1373\/clinchem.2010.157198","volume":"57","author":"JS McDonald","year":"2011","unstructured":"McDonald JS, Milosevic D, Reddi HV, Grebe SK, Algeciras-Schimnich A: Analysis of circulating microRNA: preanalytical and analytical challenges. Clin Chem. 2011, 57 (6): 833-840.","journal-title":"Clin Chem"},{"key":"1645_CR33","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1038\/ncomms4000","volume":"4","author":"DJ Son","year":"2013","unstructured":"Son DJ, Kumar S, Takabe W, Kim CW, Ni CW, Alberts-Grill N, Jang IH, Kim S, Kim W, Won Kang S, Baker AH, Woong Seo J, Ferrara KW, Jo H: The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nat Commun. 2013, 4: 3000-","journal-title":"Nat Commun"},{"issue":"9","key":"1645_CR34","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/labinvest.2012.85","volume":"92","author":"T Gui","year":"2012","unstructured":"Gui T, Zhou G, Sun Y, Shimokado A, Itoh S, Oikawa K, Muragaki Y: MicroRNAs that target Ca (2+) transporters are involved in vascular smooth muscle cell calcification. Lab Invest. 2012, 92 (9): 1250-1259.","journal-title":"Lab Invest"},{"issue":"8","key":"1645_CR35","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1007\/s10096-014-2087-x","volume":"33","author":"L Yu","year":"2014","unstructured":"Yu L, Liao Q, Zeng X, Lv Z, Zheng H, Zhao Y, Sun X, Wu Z: MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model. Eur J Clin Microbiol Infect Dis. 2014, 33 (8): 1457-1465.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"30","key":"1645_CR36","doi-asserted-by":"publisher","first-page":"26487","DOI":"10.1074\/jbc.M110.213561","volume":"286","author":"L Tserel","year":"2011","unstructured":"Tserel L, Runnel T, Kisand K, Pihlap M, Bakhoff L, Kolde R, Peterson H, Vilo J, Peterson P, Rebane A: MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4. J Biol Chem. 2011, 286 (30): 26487-26495.","journal-title":"J Biol Chem"},{"issue":"1","key":"1645_CR37","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1073\/pnas.1011549108","volume":"108","author":"B Hou","year":"2011","unstructured":"Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F: Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A. 2011, 108 (1): 278-283.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1645_CR38","doi-asserted-by":"publisher","first-page":"511","DOI":"10.4149\/neo_2013_066","volume":"60","author":"H Li","year":"2013","unstructured":"Li H, Zhao J, Zhang JW, Huang QY, Huang JZ, Chi LS, Tang HJ, Liu GQ, Zhu DJ, Ma WM: MicroRNA-217, down-regulated in clear cell renal cell carcinoma and associated with lower survival, suppresses cell proliferation and migration. Neoplasma. 2013, 60 (5): 511-515.","journal-title":"Neoplasma"},{"issue":"10","key":"1645_CR39","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1093\/carcin\/bgq160","volume":"31","author":"WG Zhao","year":"2010","unstructured":"Zhao WG, Yu SN, Lu ZH, Ma YH, Gu YM, Chen J: The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. Carcinogenesis. 2010, 31 (10): 1726-1733.","journal-title":"Carcinogenesis"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-3305-7-433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:46:00Z","timestamp":1630565160000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/1756-3305-7-433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,8]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1645"],"URL":"https:\/\/doi.org\/10.1186\/1756-3305-7-433","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,8]]},"assertion":[{"value":"4 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"433"}}