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The present study was designed to investigate the effect of maternal epileptic seizure on apoptotic neuronal death, modulation of GABA<jats:sub>B1<\/jats:sub>receptor (R), and protein kinase A-\u03b1 (PKA) in prenatal rat hippocampal neurons at gestational days (GD) 17.5. Seizure was induced in pregnant rat using intraperitoneal injection of pentylenetetrazol (PTZ) (40 mg\/kg for 15 days). To confirm the seizure electroencephalography (EEG) data was obtained by the Laxtha EEG-monitoring device in the EEG recording room and EEG were monitored 5 min and 15 min after PTZ injection. The RT-PCR and Western blot results showed significant increased expression of cytochrome-c and caspases-3, while decreased levels of GABA<jats:sub>B1<\/jats:sub>R, and PKA protein expression upon ethanol, PTZ and ethanol plus PTZ exposure in primary neuronal cells cultured from PTZ-induced seizure model as compare to non-PTZ treated maternal group. Apoptotic neurodegeneration was further confirmed with Fluoro-Jade B and propidium iodide staining, where neurons were scattered and shrunken, with markedly condensed nuclei in PTZ treated group compared with control. This study for the first time indicate that PTZ-induced seizures triggered activation of caspases-3 to induce widespread apoptotic neuronal death and decreased GABA<jats:sub>B1<\/jats:sub>R expression in hippocampal neurons, providing a possible mechanistic link between maternal epilepsy induced neurodegeneration alteration of GABA<jats:sub>B1<\/jats:sub>R and PKA expression level during prenatal brain development. This revealed new aspects of PTZ and ethanol's modulation on GABA<jats:sub>B1<\/jats:sub>R, learning and memory. Further, explain the possibility that children delivered by epileptic mothers may have higher risk of developmental disturbances and malformations.<\/jats:p>","DOI":"10.1186\/1756-6606-2-20","type":"journal-article","created":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T06:15:14Z","timestamp":1245737714000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Maternal epileptic seizure induced by Pentylenetetrazol: Apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain"],"prefix":"10.1186","volume":"2","author":[{"given":"Muhammad Imran","family":"Naseer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shupeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,6,22]]},"reference":[{"issue":"2","key":"42_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0031-9384(94)00270-F","volume":"57","author":"P De Rui","year":"1995","unstructured":"De Rui P, Mameli A, Simula M, Mameli O: Effect of fetal hypoxia on seizure susceptibility in Rats. 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