{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:48:40Z","timestamp":1761821320540},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Brain"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson\u2019s disease (PD) and dementia with Lewy bodies (DLB). Axonal swellings such as globules and spheroids are a distinct feature of axonopathy and our recent study showed that transgenic (tg) mice expressing DLB-linked P123H \u03b2-synuclein (P123H \u03b2S) were characterized by P123H \u03b2S-immunoreactive axonal swellings (P123H \u03b2S-globules). Therefore, the objectives of this study were to evaluate \u03b1-synuclein (\u03b1S)-immunoreactive axonal swellings (\u03b1S-globules) in the brains of tg mice expressing human wild-type \u03b1S and to compare them with the globules in P123H \u03b2S tg mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In \u03b1S tg mice, \u03b1S-globules were formed in an age-dependent manner in various brain regions, including the thalamus and basal ganglia. These globules were composed of autophagosome-like membranous structures and were reminiscent of P123H \u03b2S-globules in P123H \u03b2S tg mice. In the \u03b1S-globules, frequent clustering and deformation of mitochondria were observed. These changes were associated with oxidative stress, based on staining of nitrated \u03b1S and 4-hydroxy-2-nonenal (4-HNE). In accord with the absence of mitochondria in the P123H \u03b2S-globules, staining of nitrated \u03b1S and 4-HNE in these globules was weaker than that for \u03b1S-globules. Leucine-rich repeat kinase 2 (LRRK2), the PARK8 of familial PD, was detected exclusively in \u03b1S-globules, suggesting a specific role of this molecule in these globules.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Lysosomal pathology was similarly observed for both \u03b1S- and P123H \u03b2S-globules, while oxidative stress was associated with the \u03b1S-globules, and to a lesser extent with the P123H \u03b2S-globules. Other pathologies, such as mitochondrial alteration and LRRK2 accumulation, were exclusively detected for \u03b1S-globules. Collectively, both \u03b1S- and P123H \u03b2S-globules were formed through similar but distinct pathogenic mechanisms. Our findings suggest that synuclein family members might contribute to diverse axonal pathologies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1756-6606-5-34","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T08:22:50Z","timestamp":1348734170000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Distinct mechanisms of axonal globule formation in mice expressing human wild type \u03b1-synuclein or dementia with Lewy bodies-linked P123H \u00df-synuclein"],"prefix":"10.1186","volume":"5","author":[{"given":"Akio","family":"Sekigawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Sekiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Rockenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert R","family":"La Spada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,26]]},"reference":[{"key":"184_CR1","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/sj.cdd.4400432","volume":"5","author":"JQ Trojanowski","year":"1998","unstructured":"Trojanowski JQ, Goedert M, Iwatsubo T, Lee VM: Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ. 1998, 5: 832-837. 10.1038\/sj.cdd.4400432.","journal-title":"Cell Death Differ"},{"key":"184_CR2","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1750-3639.1999.tb00552.x","volume":"9","author":"M Hashimoto","year":"1999","unstructured":"Hashimoto M, Masliah E: Alpha-synuclein in Lewy body disease and Alzheimer's disease. Brain Pathol. 1999, 9: 707-720.","journal-title":"Brain Pathol"},{"key":"184_CR3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","volume":"318","author":"H Braak","year":"2004","unstructured":"Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K: Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 2004, 318: 121-134. 10.1007\/s00441-004-0956-9.","journal-title":"Cell Tissue Res"},{"key":"184_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","volume":"396","author":"H Braak","year":"2006","unstructured":"Braak H, de Vos RA, Bohl J, Del Tredici K: Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett. 2006, 396: 67-72. 10.1016\/j.neulet.2005.11.012.","journal-title":"Neurosci Lett"},{"key":"184_CR5","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/brain\/awm302","volume":"131","author":"S Orimo","year":"2008","unstructured":"Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, Takahashi H: Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain. 2008, 131: 642-650. 10.1093\/brain\/awm302.","journal-title":"Brain"},{"key":"184_CR6","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1126\/science.287.5456.1265","volume":"287","author":"E Masliah","year":"2000","unstructured":"Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L: Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science. 2000, 287: 1265-1269. 10.1126\/science.287.5456.1265.","journal-title":"Science"},{"key":"184_CR7","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1523\/JNEUROSCI.20-16-06021.2000","volume":"20","author":"H van der Putten","year":"2000","unstructured":"van der Putten H, Wiederhold KH, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren WP, Ruegg MA, et al: Neuropathology in mice expressing human alpha-synuclein. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2000, 20: 6021-6029.","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"184_CR8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0896-6273(02)00682-7","volume":"34","author":"BI Giasson","year":"2002","unstructured":"Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM: Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 2002, 34: 521-533. 10.1016\/S0896-6273(02)00682-7.","journal-title":"Neuron"},{"key":"184_CR9","doi-asserted-by":"publisher","first-page":"8968","DOI":"10.1073\/pnas.132197599","volume":"99","author":"MK Lee","year":"2002","unstructured":"Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL: Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 \u2013\u2009>\u2009Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci USA. 2002, 99: 8968-8973. 10.1073\/pnas.132197599.","journal-title":"Proc Natl Acad Sci USA"},{"key":"184_CR10","doi-asserted-by":"publisher","first-page":"13450","DOI":"10.1073\/pnas.96.23.13450","volume":"96","author":"JE Galvin","year":"1999","unstructured":"Galvin JE, Uryu K, Lee VM, Trojanowski JQ: Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc Natl Acad Sci USA. 1999, 96: 13450-13455. 10.1073\/pnas.96.23.13450.","journal-title":"Proc Natl Acad Sci USA"},{"key":"184_CR11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0002-9440(10)64548-8","volume":"157","author":"JE Galvin","year":"2000","unstructured":"Galvin JE, Giasson B, Hurtig HI, Lee VM, Trojanowski JQ: Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Am J Pathol. 2000, 157: 361-368. 10.1016\/S0002-9440(10)64548-8.","journal-title":"Am J Pathol"},{"key":"184_CR12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2217\/fnl.12.5","volume":"7","author":"M Hashimoto","year":"2012","unstructured":"Hashimoto M, La Spada AR: \u03b2-synuclein in the pathogenesis of Parkinson's disease and related \u03b1-synucleinopathies: emerging roles and new directions. Future Neurology. 2012, 7: 155-163. 10.2217\/fnl.12.5.","journal-title":"Future Neurology"},{"key":"184_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/exnr.2002.7961","volume":"177","author":"M Sakamoto","year":"2002","unstructured":"Sakamoto M, Uchihara T, Hayashi M, Nakamura A, Kikuchi E, Mizutani T, Mizusawa H, Hirai S: Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red. Exp Neurol. 2002, 177: 88-94. 10.1006\/exnr.2002.7961.","journal-title":"Exp Neurol"},{"key":"184_CR14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1750-3639.2011.00509.x","volume":"22","author":"T Kanazawa","year":"2012","unstructured":"Kanazawa T, Adachi E, Orimo S, Nakamura A, Mizusawa H, Uchihara T: Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals. Brain Pathol. 2012, 22: 67-78. 10.1111\/j.1750-3639.2011.00509.x.","journal-title":"Brain Pathol"},{"key":"184_CR15","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/ncomms1101","volume":"1","author":"M Fujita","year":"2010","unstructured":"Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, et al: A beta-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nat Commun. 2010, 1: 110-10.1038\/ncomms1101.","journal-title":"Nat Commun"},{"key":"184_CR16","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/BF00687268","volume":"72","author":"E Iseki","year":"1987","unstructured":"Iseki E, Amano N, Yokoi S, Yamada Y, Suzuki K, Yazaki M: A case of adult neuronal ceroid-lipofuscinosis with the appearance of membranous cytoplasmic bodies localized in the spinal anterior horn. Acta Neuropathol. 1987, 72: 362-368. 10.1007\/BF00687268.","journal-title":"Acta Neuropathol"},{"key":"184_CR17","first-page":"537","volume":"39","author":"Y Kurokawa","year":"1985","unstructured":"Kurokawa Y, Ueno T, Nakamura N, Kimura N: Deposits of neuronal ceroid-lipofuscinosis in transitional structures\u2013electron microscopic study. Folia Psychiatr Neurol Jpn. 1985, 39: 537-542.","journal-title":"Folia Psychiatr Neurol Jpn"},{"key":"184_CR18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/glycob\/3.2.137","volume":"3","author":"M Kotani","year":"1993","unstructured":"Kotani M, Kawashima I, Ozawa H, Terashima T, Tai T: Differential distribution of major gangliosides in rat central nervous system detected by specific monoclonal antibodies. Glycobiology. 1993, 3: 137-146. 10.1093\/glycob\/3.2.137.","journal-title":"Glycobiology"},{"key":"184_CR19","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1093\/glycob\/4.6.855","volume":"4","author":"M Kotani","year":"1994","unstructured":"Kotani M, Kawashima I, Ozawa H, Ogura K, Ishizuka I, Terashima T, Tai T: Immunohistochemical localization of minor gangliosides in the rat central nervous system. Glycobiology. 1994, 4: 855-865. 10.1093\/glycob\/4.6.855.","journal-title":"Glycobiology"},{"key":"184_CR20","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/cr.2009.98","volume":"19","author":"F Tomasello","year":"2009","unstructured":"Tomasello F, Messina A, Lartigue L, Schembri L, Medina C, Reina S, Thoraval D, Crouzet M, Ichas F, De Pinto V, De Giorgi F: Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis. Cell Res. 2009, 19: 1363-1376. 10.1038\/cr.2009.98.","journal-title":"Cell Res"},{"key":"184_CR21","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/ng1769","volume":"38","author":"A Bender","year":"2006","unstructured":"Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, et al: High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet. 2006, 38: 515-517. 10.1038\/ng1769.","journal-title":"Nat Genet"},{"key":"184_CR22","doi-asserted-by":"publisher","first-page":"8624","DOI":"10.1523\/JNEUROSCI.1957-08.2008","volume":"28","author":"Y Hayashi","year":"2008","unstructured":"Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H: Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2008, 28: 8624-8634. 10.1523\/JNEUROSCI.1957-08.2008.","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"184_CR23","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1002\/jnr.22089","volume":"87","author":"K Ubhi","year":"2009","unstructured":"Ubhi K, Lee PH, Adame A, Inglis C, Mante M, Rockenstein E, Stefanova N, Wenning GK, Masliah E: Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J Neurosci Res. 2009, 87: 2728-2739. 10.1002\/jnr.22089.","journal-title":"J Neurosci Res"},{"key":"184_CR24","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1111\/j.1742-4658.2008.06301.x","volume":"275","author":"AC Belin","year":"2008","unstructured":"Belin AC, Westerlund M: Parkinson's disease: a genetic perspective. FEBS J. 2008, 275: 1377-1383. 10.1111\/j.1742-4658.2008.06301.x.","journal-title":"FEBS J"},{"key":"184_CR25","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/ng.485","volume":"41","author":"W Satake","year":"2009","unstructured":"Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, et al: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet. 2009, 41: 1303-1307. 10.1038\/ng.485.","journal-title":"Nat Genet"},{"key":"184_CR26","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1016\/j.yexcr.2008.02.015","volume":"314","author":"N Shin","year":"2008","unstructured":"Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, et al: LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res. 2008, 314: 2055-2065. 10.1016\/j.yexcr.2008.02.015.","journal-title":"Exp Cell Res"},{"key":"184_CR27","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/ana.21019","volume":"60","author":"S Biskup","year":"2006","unstructured":"Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, et al: Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol. 2006, 60: 557-569. 10.1002\/ana.21019.","journal-title":"Ann Neurol"},{"key":"184_CR28","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/ana.20791","volume":"59","author":"BI Giasson","year":"2006","unstructured":"Giasson BI, Covy JP, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin VM: Biochemical and pathological characterization of Lrrk2. Ann Neurol. 2006, 59: 315-322. 10.1002\/ana.20791.","journal-title":"Ann Neurol"},{"key":"184_CR29","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.neuroscience.2007.05.027","volume":"147","author":"HL Melrose","year":"2007","unstructured":"Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, et al: A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience. 2007, 147: 1047-1058. 10.1016\/j.neuroscience.2007.05.027.","journal-title":"Neuroscience"},{"key":"184_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0076-6879(08)04006-8","volume":"453","author":"DS Yang","year":"2009","unstructured":"Yang DS, Lee JH, Nixon RA: Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases. Methods Enzymol. 2009, 453: 111-144.","journal-title":"Methods Enzymol"},{"key":"184_CR31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1750-3639.2011.00545.x","volume":"22","author":"CL Kragh","year":"2012","unstructured":"Kragh CL, Ubhi K, Wyss-Corey T, Masliah E: Autophagy in dementias. Brain Pathol. 2012, 22: 99-109. 10.1111\/j.1750-3639.2011.00545.x.","journal-title":"Brain Pathol"},{"key":"184_CR32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1523\/JNEUROSCI.4308-05.2006","volume":"26","author":"LJ Martin","year":"2006","unstructured":"Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK: Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2006, 26: 41-50. 10.1523\/JNEUROSCI.4308-05.2006.","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"184_CR33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nchembio782","volume":"2","author":"DA Bosco","year":"2006","unstructured":"Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW: Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol. 2006, 2: 249-253.","journal-title":"Nat Chem Biol"},{"key":"184_CR34","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.neuron.2006.10.008","volume":"52","author":"D MacLeod","year":"2006","unstructured":"MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A: The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron. 2006, 52: 587-593. 10.1016\/j.neuron.2006.10.008.","journal-title":"Neuron"},{"key":"184_CR35","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nn.2349","volume":"12","author":"Y Li","year":"2009","unstructured":"Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, et al: Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci. 2009, 12: 826-828. 10.1038\/nn.2349.","journal-title":"Nat Neurosci"},{"key":"184_CR36","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.neuron.2009.11.006","volume":"64","author":"X Lin","year":"2009","unstructured":"Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, et al: Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009, 64: 807-827. 10.1016\/j.neuron.2009.11.006.","journal-title":"Neuron"},{"key":"184_CR37","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/jnr.10231","volume":"68","author":"E Rockenstein","year":"2002","unstructured":"Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E: Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res. 2002, 68: 568-578. 10.1002\/jnr.10231.","journal-title":"J Neurosci Res"},{"key":"184_CR38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/neuro.04.004.2009","volume":"3","author":"Y Kubota","year":"2009","unstructured":"Kubota Y, Hatada SN, Kawaguchi Y: Important factors for the three-dimensional reconstruction of neuronal structures from serial ultrathin sections. Frontiers in Neural Circuits. 2009, 3: 4-","journal-title":"Frontiers in Neural Circuits"},{"key":"184_CR39","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1210\/endo.140.5.6685","volume":"140","author":"M Maruyama","year":"1999","unstructured":"Maruyama M, Matsumoto H, Fujiwara K, Kitada C, Hinuma S, Onda H, Fujino M, Inoue K: Immunocytochemical localization of prolactin-releasing peptide in the rat brain. Endocrinology. 1999, 140: 2326-2333. 10.1210\/en.140.5.2326.","journal-title":"Endocrinology"},{"key":"184_CR40","first-page":"314","volume":"35","author":"A Schultz","year":"1924","unstructured":"Schultz A: Eine Methode des mikrochemischen Cholesterinnachweises am Gewebsschnitt. Zentralblatt fur Allgemeine pathologie und Pathologische Anatomie. 1924, 35: 314-317.","journal-title":"Zentralblatt fur Allgemeine pathologie und Pathologische Anatomie"}],"container-title":["Molecular Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-6606-5-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T21:31:22Z","timestamp":1630531882000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularbrain.biomedcentral.com\/articles\/10.1186\/1756-6606-5-34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,26]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["184"],"URL":"https:\/\/doi.org\/10.1186\/1756-6606-5-34","relation":{},"ISSN":["1756-6606"],"issn-type":[{"value":"1756-6606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,26]]},"assertion":[{"value":"11 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"34"}}