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AF occurs in up to 15% of patients with hyperthyroidism compared to 4% of people in the general population and is more common in men and in patients with triiodothyronine (T\n                    <jats:sub>3<\/jats:sub>\n                    ) toxicosis. The incidence of AF increases with advancing age. Also, subclinical hyperthyroidism is a risk factor associated with a 3-fold increase in development of AF. Thyrotoxicosis exerts marked influences on electrical impulse generation (chronotropic effect) and conduction (dromotropic effect). Several potential mechanisms could be invoked for the effect of thyroid hormones on AF risk, including elevation of left atrial pressure secondary to increased left ventricular mass and impaired ventricular relaxation, ischemia resulting from increased resting heart rate, and increased atrial eopic activity. Reentry has been postulated as one of the main mechanisms leading to AF. AF is more likely if effective refractory periods are short and conduction is slow. Hyperthyroidism is associated with shortening of action potential duration which may also contribute to AF.\n                  <\/jats:p>","DOI":"10.1186\/1756-6614-2-4","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T14:14:28Z","timestamp":1238681668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["The mechanisms of atrial fibrillation in hyperthyroidism"],"prefix":"10.1186","volume":"2","author":[{"given":"Agata","family":"Bielecka-Dabrowa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri P","family":"Mikhailidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Rysz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,2]]},"reference":[{"key":"12_CR1","first-page":"229","volume":"3","author":"M Banach","year":"2007","unstructured":"Banach M, Misztal M, Goch A, Rysz J, Goch JH: Predictors of atrial fibrillation in patients following isolated surgical revascularization. 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