{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:28:41Z","timestamp":1791073721147,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>In a human T-cell acute lymphoblastic leukemia (T-ALL) cell line (Molt-4), siRNA-mediated suppression of <jats:italic>BCL11B<\/jats:italic> expression was shown to inhibit proliferation and induce apoptosis, functions which may be related to genes involved in apoptosis (such as <jats:italic>TNFSF10<\/jats:italic> and <jats:italic>BCL2L1<\/jats:italic>) and TGF-\u03b2 pathways (such as <jats:italic>SPP1<\/jats:italic> and <jats:italic>CREBBP<\/jats:italic>).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The expression levels of the above mentioned genes and their correlation with the <jats:italic>BCL11B<\/jats:italic> gene were analyzed in patients with T-ALL using the TaqMan and SYBR Green I real-time polymerase chain reaction technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Expression levels of <jats:italic>BCL11B, BCL2L1<\/jats:italic>, and <jats:italic>CREBBP<\/jats:italic> mRNA in T-ALL patients were significantly higher than those from healthy controls (<jats:italic>P &lt;<\/jats:italic> 0.05). In T-ALL patients, the <jats:italic>BCL11B<\/jats:italic> expression level was negatively correlated with the <jats:italic>BCL2L1<\/jats:italic> expression level (<jats:italic>r<\/jats:italic>\n              <jats:sub>s<\/jats:sub> = -0.700; <jats:italic>P<\/jats:italic>\n              <jats:italic>&lt;<\/jats:italic> 0.05), and positively correlated with the <jats:italic>SPP1<\/jats:italic> expression level (<jats:italic>r<\/jats:italic>\n              <jats:sub>s<\/jats:sub> = 0.683; <jats:italic>P<\/jats:italic>\n              <jats:italic>&lt;<\/jats:italic> 0.05). In healthy controls, the <jats:italic>BCL11B<\/jats:italic> expression level did not correlate with the <jats:italic>TNFSF10<\/jats:italic>, <jats:italic>BCL2L1<\/jats:italic>, <jats:italic>SPP1<\/jats:italic>, or <jats:italic>CREBBP<\/jats:italic> expression levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Over-expression of <jats:italic>BCL11B<\/jats:italic> might play a role in anti-apoptosis in T-ALL cells through up-regulation of its downstream genes <jats:italic>BCL2L1<\/jats:italic> and <jats:italic>CREBBP<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1756-8722-3-44","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T19:16:10Z","timestamp":1290798970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia"],"prefix":"10.1186","volume":"3","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liye","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,16]]},"reference":[{"key":"128_CR1","first-page":"743","volume-title":"Principles and Practice of Hematology. 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