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TCR\u03b6 3'-UTR splice variants were identified in peripheral blood mononuclear cells (PBMCs) from 14 healthy individuals, 40 patients with CML and 22 patients with CML in complete remission (CML-CR) by RT-PCR. The expression level of the TCR\u03b6, Fc\u03b5RI\u03b3, ASF\/SF-2 and ZAP-70 genes was analyzed by real-time quantitative PCR. While the expression of TCR\u03b6 gene in the CML group was significantly lower than that in the healthy individual and CML-CR groups, a significantly higher expression of the FceRI\u03b3 and ASF\/SF-2 genes was found in the CML group. Two types of splicing forms were detected in all of the healthy individual CML-CR cases: wild type (WT) TCR\u03b6 3'-UTR and alternatively splieced (AS) TCR\u03b6 3'-UTR which have been alternatively splieced in the WT TCR\u03b6 3'-UTR . However, 35% of the CML cases contained only the wild type TCR\u03b6 3'-UTR isoform. Based on the TCR\u03b6 3'-UTR isoform expression characteristic, we divided the patients with CML into two subgroups: the WT<jats:sup>+<\/jats:sup>AS<jats:sup>-<\/jats:sup>CML group, containing patients that express only the wild type TCR\u03b6 3'-UTR, and the WT<jats:sup>+<\/jats:sup>AS<jats:sup>+<\/jats:sup>CML group, which contained patients that expressed two TCR\u03b6 3'-UTR isoforms. A significantly different ASF\/SF-2 and Fc\u03b5RI\u03b3 gene expression pattern was found between the WT<jats:sup>+<\/jats:sup>AS<jats:sup>-<\/jats:sup>and WT<jats:sup>+<\/jats:sup>AS<jats:sup>+<\/jats:sup>CML groups. We concluded that defective TCR\u03b6 expression may be characterized in the WT<jats:sup>+<\/jats:sup>AS<jats:sup>-<\/jats:sup>and WT<jats:sup>+<\/jats:sup>AS<jats:sup>+<\/jats:sup>CML subgroups by the different gene expression pattern. The overexpression of ASF\/SF2, which alternatively splices the TCR\u03b6 3\u2019-UTR, is thought to participate in feedback regulation. The characteristics of TCR\u03b6 3'-UTR alternative splicing may be a novel immunological marker for the evaluation of the CML immune status.<\/jats:p>","DOI":"10.1186\/1756-8722-5-74","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T11:14:35Z","timestamp":1355138075000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Alternative expression of TCR\u03b6 related genes in patients with chronic myeloid leukemia"],"prefix":"10.1186","volume":"5","author":[{"given":"Xianfeng","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"270_CR1","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1007\/s00262-011-1126-z","volume":"60","author":"M Smahel","year":"2011","unstructured":"Smahel M: Antigens in chronic myeloid leukemia: implications for vaccine development. 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