{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:16:36Z","timestamp":1789665396641,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1756-8722-6-45","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T12:17:59Z","timestamp":1372681079000},"source":"Crossref","is-referenced-by-count":30,"title":["Early stage follicular lymphoma: what is the clinical impact of the first-line treatment strategy?"],"prefix":"10.1186","volume":"6","author":[{"given":"Anne-Sophie AS","family":"Michallet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure L","family":"Lebras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah D","family":"Bauwens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadhela F","family":"Bouafia-Sauvy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise F","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle C","family":"Tychyj-Pinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne A","family":"D\u2019Hombres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles G","family":"Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand B","family":"Coiffier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,1]]},"reference":[{"key":"322_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s11864-005-0034-x","volume":"6","author":"CG Peterson","year":"2005","unstructured":"Peterson CG, Kahl BS: Follicular lymphoma: management options in the era of targeted therapy. Current treatment options in oncology. 2005, 6: 297-308. 10.1007\/s11864-005-0034-x.","journal-title":"Current treatment options in oncology"},{"key":"322_CR2","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/S0360-3016(01)01747-3","volume":"51","author":"RB Wilder","year":"2001","unstructured":"Wilder RB, Jones D, Tucker SL: Long-term results with radiotherapy for Stage I-II follicular lymphomas. International journal of radiation oncology, biology, physics. 2001, 51: 1219-1227. 10.1016\/S0360-3016(01)01747-3.","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"322_CR3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1200\/JCO.1996.14.4.1282","volume":"14","author":"MP Mac Manus","year":"1996","unstructured":"Mac Manus MP, Hoppe RT: Is radiotherapy curative for stage I and II low-grade follicular lymphoma? Results of a long-term follow-up study of patients treated at Stanford University. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 1996, 14: 1282-1290.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"322_CR4","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/bjc.1994.213","volume":"69","author":"B Vaughan Hudson","year":"1994","unstructured":"Vaughan Hudson B, Vaughan Hudson G, MacLennan KA: Clinical stage 1 non-Hodgkin's lymphoma: long-term follow-up of patients treated by the British National Lymphoma Investigation with radiotherapy alone as initial therapy. British journal of cancer. 1994, 69: 1088-1093. 10.1038\/bjc.1994.213.","journal-title":"British journal of cancer"},{"key":"322_CR5","first-page":"2342","volume":"71","author":"J Yahalom","year":"1993","unstructured":"Yahalom J, Varsos G, Fuks Z: Adjuvant cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy after radiation therapy in stage I low-grade and intermediate-grade non-Hodgkin lymphoma. Results of a prospective randomized study. Cancer. 1993, 71: 2342-2350.","journal-title":"Results of a prospective randomized study. Cancer"},{"key":"322_CR6","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1200\/JCO.2003.07.111","volume":"21","author":"JF Seymour","year":"2003","unstructured":"Seymour JF, Pro B, Fuller LM: Long-term follow-up of a prospective study of combined modality therapy for stage I-II indolent non-Hodgkin's lymphoma. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2003, 21: 2115-2122. 10.1200\/JCO.2003.07.111.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"322_CR7","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/oxfordjournals.annonc.a010720","volume":"7","author":"P Soubeyran","year":"1996","unstructured":"Soubeyran P, Eghbali H, Trojani M: Is there any place for a wait-and-see policy in stage I0 follicular lymphoma? A study of 43 consecutive patients in a single center. Annals of oncology: official journal of the European Society for Medical Oncology\/ESMO. 1996, 7: 713-718. 10.1093\/oxfordjournals.annonc.a010720.","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology\/ESMO"},{"key":"322_CR8","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1200\/JCO.2004.10.086","volume":"22","author":"R Advani","year":"2004","unstructured":"Advani R, Rosenberg SA, Horning SJ: Stage I and II follicular non-Hodgkin's lymphoma: long-term follow-up of no initial therapy. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2004, 22: 1454-1459. 10.1200\/JCO.2004.10.086.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"Suppl 5","key":"322_CR9","doi-asserted-by":"publisher","first-page":"v181","DOI":"10.1093\/annonc\/mdq184","volume":"21","author":"M Dreyling","year":"2010","unstructured":"Dreyling M: Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology: official journal of the European Society for Medical Oncology\/ESMO. 2010, 21 (Suppl 5): v181-183.","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology\/ESMO"},{"key":"322_CR10","first-page":"1236","volume":"90","author":"G Barosi","year":"2005","unstructured":"Barosi G, Carella A, Lazzarino M: Management of nodal indolent (non marginal-zone) non-Hodgkin's lymphomas: practice guidelines from the Italian Society of Hematology, Italian Society of Experimental Hematology and Italian Group for Bone Marrow Transplantation. Haematologica. 2005, 90: 1236-1257.","journal-title":"Haematologica"},{"key":"322_CR11","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1002\/cncr.25149","volume":"116","author":"TJ Pugh","year":"2010","unstructured":"Pugh TJ, Ballonoff A, Newman F, Rabinovitch R: Improved survival in patients with early stage low-grade follicular lymphoma treated with radiation: a Surveillance, Epidemiology, and End Results database analysis. Cancer. 2010, 116: 3843-3851. 10.1002\/cncr.25149.","journal-title":"Cancer"},{"issue":"Suppl 6","key":"322_CR12","doi-asserted-by":"crossref","first-page":"vi59","DOI":"10.1093\/annonc\/mdr388","volume":"22","author":"M Dreyling","year":"2011","unstructured":"Dreyling M, Ghielmini M, Marcus R: Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology: official journal of the European Society for Medical Oncology\/ESMO. 2011, 22 (Suppl 6): vi59-63.","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology\/ESMO"},{"key":"322_CR13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1200\/JCO.1997.15.4.1587","volume":"15","author":"Y Bastion","year":"1997","unstructured":"Bastion Y, Sebban C, Berger F: Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 1997, 15: 1587-1594.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"322_CR14","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.blre.2004.09.001","volume":"19","author":"MK Gandhi","year":"2005","unstructured":"Gandhi MK, Marcus RE: Follicular lymphoma: time for a re-think?. Blood reviews. 2005, 19: 165-178. 10.1016\/j.blre.2004.09.001.","journal-title":"Blood reviews"},{"key":"322_CR15","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0360-3016(99)00051-6","volume":"44","author":"SS Kamath","year":"1999","unstructured":"Kamath SS, Marcus RB, Lynch JW, Mendenhall NP: The impact of radiotherapy dose and other treatment-related and clinical factors on in-field control in stage I and II non-Hodgkin's lymphoma. International journal of radiation oncology, biology, physics. 1999, 44: 563-568. 10.1016\/S0360-3016(99)00051-6.","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"322_CR16","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.ijrobp.2005.08.010","volume":"64","author":"BA Guadagnolo","year":"2006","unstructured":"Guadagnolo BA, Li S, Neuberg D: Long-term outcome and mortality trends in early-stage, Grade 1\u20132 follicular lymphoma treated with radiation therapy. International journal of radiation oncology, biology, physics. 2006, 64: 928-934. 10.1016\/j.ijrobp.2005.08.010.","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"322_CR17","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1002\/cncr.25117","volume":"116","author":"BA Campbell","year":"2010","unstructured":"Campbell BA, Voss N, Woods R: Long-term outcomes for patients with limited stage follicular lymphoma: involved regional radiotherapy versus involved node radiotherapy. Cancer. 2010, 116: 3797-3806. 10.1002\/cncr.25117.","journal-title":"Cancer"},{"key":"322_CR18","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.radonc.2011.05.013","volume":"100","author":"L Lowry","year":"2011","unstructured":"Lowry L, Smith P, Qian W: Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology. 2011, 100: 86-92. 10.1016\/j.radonc.2011.05.013.","journal-title":"Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology"},{"key":"322_CR19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1471-2407-11-87","volume":"11","author":"M Witzens-Harig","year":"2011","unstructured":"Witzens-Harig M, Hensel M, Unterhalt M, Herfarth K: Treatment of limited stage follicular lymphoma with Rituximab immunotherapy and involved field radiotherapy in a prospective multicenter Phase II trial-MIR trial. BMC cancer. 2011, 11: 87-10.1186\/1471-2407-11-87.","journal-title":"BMC cancer"},{"key":"322_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/BF02990087","volume":"11","author":"SM Kelsey","year":"1994","unstructured":"Kelsey SM, Newland AC, Hudson GV, Jelliffe AM: A British National Lymphoma Investigation randomised trial of single agent chlorambucil plus radiotherapy versus radiotherapy alone in low grade, localised non-Hodgkins lymphoma. Medical oncology. 1994, 11: 19-25. 10.1007\/BF02990087.","journal-title":"Medical oncology"},{"key":"322_CR21","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1200\/JCO.2011.40.6546","volume":"30","author":"JW Friedberg","year":"2012","unstructured":"Friedberg JW, Byrtek M, Link BK: Effectiveness of First-Line Management Strategies for Stage I Follicular Lymphoma: Analysis of the National LymphoCare Study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2012, 30: 3368-3375. 10.1200\/JCO.2011.40.6546.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"322_CR22","volume-title":"Watchful Waiting in Low-Tumor Burden Follicular Lymphoma in the Rituximab Era","author":"P Solal-Celigny","year":"2012","unstructured":"Solal-Celigny P, Bellei M, Marcheselli L: Watchful Waiting in Low-Tumor Burden Follicular Lymphoma in the Rituximab Era. 2012, official journal of the American Society of Clinical Oncology: Results of an F2-Study Database. Journal of clinical oncology"},{"key":"322_CR23","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/jnci\/djk152","volume":"99","author":"H Schulz","year":"2007","unstructured":"Schulz H, Bohlius JF, Trelle S: Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis. Journal of the National Cancer Institute. 2007, 99: 706-714. 10.1093\/jnci\/djk152.","journal-title":"Journal of the National Cancer Institute"},{"key":"322_CR24","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.1200\/JCO.2012.43.5768","volume":"30","author":"S Montoto","year":"2012","unstructured":"Montoto S: Management of localized-stage follicular lymphoma: changing the paradigm?. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2012, 30: 3328-3329. 10.1200\/JCO.2012.43.5768.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"322_CR25","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1182\/blood.V99.10.3806","volume":"99","author":"G Ott","year":"2002","unstructured":"Ott G, Katzenberger T, Lohr A: Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3. Blood. 2002, 99: 3806-3812. 10.1182\/blood.V99.10.3806.","journal-title":"Blood"},{"key":"322_CR26","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1182\/blood-2003-12-4434","volume":"104","author":"P Solal-Celigny","year":"2004","unstructured":"Solal-Celigny P, Roy P, Colombat P: Follicular lymphoma international prognostic index. Blood. 2004, 104: 1258-1265. 10.1182\/blood-2003-12-4434.","journal-title":"Blood"}],"container-title":["Journal of Hematology &amp; Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-8722-6-45.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-8722-6-45\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-8722-6-45.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T12:09:19Z","timestamp":1596024559000},"score":1,"resource":{"primary":{"URL":"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/1756-8722-6-45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["322"],"URL":"https:\/\/doi.org\/10.1186\/1756-8722-6-45","relation":{},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,1]]},"article-number":"45"}}