{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:13:57Z","timestamp":1770912837534,"version":"3.50.1"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematol Oncol"],"DOI":"10.1186\/1756-8722-7-29","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T17:01:55Z","timestamp":1396285315000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells"],"prefix":"10.1186","volume":"7","author":[{"given":"Ulrike","family":"Erb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelie Pajip","family":"Megaptche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus W","family":"B\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Z\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,31]]},"reference":[{"key":"382_CR1","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/0092-8674(89)90639-9","volume":"56","author":"LA Goldstein","year":"1989","unstructured":"Goldstein LA, Zhou DF, Picker LJ, Minty CN, Bargatze RF, Ding JF, Butcher EC: A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell. 1989, 56: 1063-1072. 10.1016\/0092-8674(89)90639-9.","journal-title":"Cell"},{"key":"382_CR2","doi-asserted-by":"publisher","first-page":"12160","DOI":"10.1073\/pnas.89.24.12160","volume":"89","author":"GR Screaton","year":"1992","unstructured":"Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI: Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA. 1992, 89: 12160-12164. 10.1073\/pnas.89.24.12160.","journal-title":"Proc Natl Acad Sci USA"},{"key":"382_CR3","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1073\/pnas.86.12.4659","volume":"86","author":"RL Idzerda","year":"1989","unstructured":"Idzerda RL, Carter WG, Nottenburg C, Wayner EA, Gallatin WM, St John T: Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium. Proc Natl Acad Sci USA. 1989, 86: 4659-4663. 10.1073\/pnas.86.12.4659.","journal-title":"Proc Natl Acad Sci USA"},{"key":"382_CR4","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/0092-8674(89)90638-7","volume":"56","author":"I Stamenkovic","year":"1989","unstructured":"Stamenkovic I, Amiot M, Pesando JM, Seed B: A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell. 1989, 56: 1057-1062. 10.1016\/0092-8674(89)90638-7.","journal-title":"Cell"},{"key":"382_CR5","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nrc3023","volume":"11","author":"M Z\u00f6ller","year":"2011","unstructured":"Z\u00f6ller M: CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?. Nat Rev Cancer. 2011, 11: 254-267. 10.1038\/nrc3023.","journal-title":"Nat Rev Cancer"},{"key":"382_CR6","volume-title":"Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process. StemBook [Internet]","author":"K Lapid","year":"2012","unstructured":"Lapid K, Glait-Santar C, Gur-Cohen S, Canaani J, Kollet O, Lapidot T: Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process. StemBook [Internet]. 2012, Cambridge (MA): Harvard Stem Cell Institute, 2008\u20132012 Dec 10"},{"key":"382_CR7","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1200\/JCO.2010.31.0904","volume":"29","author":"MY Konopleva","year":"2011","unstructured":"Konopleva MY, Jordan CT: Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol. 2011, 29: 591-559. 10.1200\/JCO.2010.31.0904.","journal-title":"J Clin Oncol"},{"key":"382_CR8","volume-title":"Hematology","author":"S Azizidoost","year":"2013","unstructured":"Azizidoost S, Babashah S, Rahim F, Shahjahani M, Saki N: Bone marrow neoplastic niche in leukemia. Hematology. 2013, PMID 23905984 [Epub ahead of print]"},{"key":"382_CR9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/wsbm.145","volume":"3","author":"MR Warr","year":"2011","unstructured":"Warr MR, Pietras EM, Passegu\u00e9 E: Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip Rev Syst Biol Med. 2011, 3: 681-701. 10.1002\/wsbm.145.","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"382_CR10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1177\/1535370213480714","volume":"238","author":"K Williams","year":"2013","unstructured":"Williams K, Motiani K, Giridhar PV, Kasper S: CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Exp Biol Med. 2013, 238: 324-338. 10.1177\/1535370213480714.","journal-title":"Exp Biol Med"},{"key":"382_CR11","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1016\/j.febslet.2011.07.039","volume":"585","author":"PP Jacobs","year":"2011","unstructured":"Jacobs PP, Sackstein R: CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett. 2011, 585: 3148-3158. 10.1016\/j.febslet.2011.07.039.","journal-title":"FEBS Lett"},{"key":"382_CR12","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1182\/blood-2005-04-1417","volume":"106","author":"T Lapidot","year":"2005","unstructured":"Lapidot T, Dar A, Kollet O: How do stem cells find their way home?. Blood. 2005, 106: 1901-1910. 10.1182\/blood-2005-04-1417.","journal-title":"Blood"},{"key":"382_CR13","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00277-011-1161-z","volume":"90","author":"MK Hertweck","year":"2011","unstructured":"Hertweck MK, Erdfelder F, Kreuzer KA: CD44 in hematological neoplasias. Ann Hematol. 2011, 90: 493-508. 10.1007\/s00277-011-1161-z.","journal-title":"Ann Hematol"},{"key":"382_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.stem.2008.02.012","volume":"2","author":"S Khaldoyanidi","year":"2008","unstructured":"Khaldoyanidi S: Directing stem cell homing. Cell Stem Cell. 2008, 2: 198-200. 10.1016\/j.stem.2008.02.012.","journal-title":"Cell Stem Cell"},{"key":"382_CR15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1084\/jem.171.2.477","volume":"171","author":"K Miyake","year":"1990","unstructured":"Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW: Monoclonal antibodies to Pgp-1\/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med. 1990, 171: 477-488. 10.1084\/jem.171.2.477.","journal-title":"J Exp Med"},{"key":"382_CR16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jlb.60.5.579","volume":"60","author":"S Khaldoyanidi","year":"1996","unstructured":"Khaldoyanidi S, Denzel A, Z\u00f6ller M: Requirement for CD44 in proliferation and homing of hematopoietic precursor cells. J Leukoc Biol. 1996, 60: 579-592.","journal-title":"J Leukoc Biol"},{"key":"382_CR17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood.V94.3.940.415k27_940_949","volume":"94","author":"S Khaldoyanidi","year":"1999","unstructured":"Khaldoyanidi S, Moll J, Karakhanova S, Herrlich P, Ponta H: Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages. Blood. 1999, 94: 940-949.","journal-title":"Blood"},{"key":"382_CR18","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s12015-010-9212-8","volume":"7","author":"LA Marquez-Curtis","year":"2011","unstructured":"Marquez-Curtis LA, Turner AR, Sridharan S, Ratajczak MZ, Janowska-Wieczorek A: The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes. Stem Cell Rev. 2011, 7: 590-607. 10.1007\/s12015-010-9212-8.","journal-title":"Stem Cell Rev"},{"key":"382_CR19","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1182\/blood-2003-10-3611","volume":"103","author":"A Avigdor","year":"2004","unstructured":"Avigdor A, Goichberg P, Shivtiel S, Dar A, Peled A, Samira S, Kollet O, Hershkoviz R, Alon R, Hardan I, Ben-Hur H, Naor D, Nagler A, Lapidot T: CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem\/progenitor cells to bone marrow. Blood. 2004, 103: 2981-2989. 10.1182\/blood-2003-10-3611.","journal-title":"Blood"},{"key":"382_CR20","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/S0301-472X(00)00674-3","volume":"29","author":"O Christ","year":"2001","unstructured":"Christ O, Kronenwett R, Haas R, Z\u00f6ller M: Combining G-CSF with a blockade of adhesion strongly improves the reconstitutive capacity of mobilized hematopoietic progenitor cells. Exp Hematol. 2001, 29: 380-390. 10.1016\/S0301-472X(00)00674-3.","journal-title":"Exp Hematol"},{"key":"382_CR21","first-page":"359","volume":"3","author":"J Liu","year":"2006","unstructured":"Liu J, Jiang G: CD44 and hematologic malignancies. Cell Mol Immunol. 2006, 3: 359-365.","journal-title":"Cell Mol Immunol"},{"key":"382_CR22","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1089\/15258160260091004","volume":"11","author":"A Hidalgo","year":"2002","unstructured":"Hidalgo A, Robledo MM, Teixid\u00f3 J: CD44-mediated hematopoietic progenitor cell adhesion and its complex role in myelopoiesis. J Hematother Stem Cell Res. 2002, 11: 539-547. 10.1089\/15258160260091004.","journal-title":"J Hematother Stem Cell Res"},{"key":"382_CR23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1582-4934.2009.00776.x","volume":"14","author":"T Walenda","year":"2010","unstructured":"Walenda T, Bork S, Horn P, Wein F, Saffrich R, Diehlmann A, Eckstein V, Ho AD, Wagner W: Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells. J Cell Mol Med. 2010, 14: 337-350. 10.1111\/j.1582-4934.2009.00776.x.","journal-title":"J Cell Mol Med"},{"key":"382_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/cyto.b.21066","volume":"84","author":"DS Krause","year":"2013","unstructured":"Krause DS, Scadden DT, Preffer FI: The hematopoietic stem cell niche\u2013home for friend and foe?. Cytometry B Clin Cytom. 2013, 84: 7-20.","journal-title":"Cytometry B Clin Cytom"},{"key":"382_CR25","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/nm1483","volume":"12","author":"L Jin","year":"2006","unstructured":"Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE: Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006, 12: 1167-1174. 10.1038\/nm1483.","journal-title":"Nat Med"},{"key":"382_CR26","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/nm1489","volume":"12","author":"DS Krause","year":"2006","unstructured":"Krause DS, Lazarides K, von Andrian UH, Van Etten RA: Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med. 2006, 12: 1175-1180. 10.1038\/nm1489.","journal-title":"Nat Med"},{"key":"382_CR27","doi-asserted-by":"publisher","first-page":"36777","DOI":"10.1074\/jbc.M112.372557","volume":"287","author":"H Fujimori","year":"2012","unstructured":"Fujimori H, Shikanai M, Teraoka H, Masutani M, Yoshioka K: Induction of cancerous stem cells during embryonic stem cell differentiation. J Biol Chem. 2012, 287: 36777-36791. 10.1074\/jbc.M112.372557.","journal-title":"J Biol Chem"},{"key":"382_CR28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jlb.63.2.175","volume":"63","author":"M Z\u00f6ller","year":"1998","unstructured":"Z\u00f6ller M, F\u00f6hr N, Herrmann K: Treatment of mice with anti-CD44 after allogeneic bone marrow cell transplantation is lethal. J Leukoc Biol. 1998, 63: 175-189.","journal-title":"J Leukoc Biol"},{"key":"382_CR29","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1111\/j.1582-4934.2009.00909.x","volume":"14","author":"M Rajasagi","year":"2010","unstructured":"Rajasagi M, von Au A, Singh R, Hartmann N, Z\u00f6ller M, Marhaba R: Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization. J Cell Mol Med. 2010, 14: 1453-1467.","journal-title":"J Cell Mol Med"},{"key":"382_CR30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1399-0039.1998.tb02273.x","volume":"52","author":"M R\u00f6sel","year":"1998","unstructured":"R\u00f6sel M, F\u00f6ger N, Z\u00f6ller M: Involvement of CD44 exon v10 in B-cell activation. Tissue Antigens. 1998, 52: 99-113. 10.1111\/j.1399-0039.1998.tb02273.x.","journal-title":"Tissue Antigens"},{"key":"382_CR31","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/(SICI)1097-4652(199706)171:3<305::AID-JCP9>3.0.CO;2-S","volume":"171","author":"M R\u00f6sel","year":"1997","unstructured":"R\u00f6sel M, Seiter S, Z\u00f6ller M: CD44v10 expression in the mouse and functional activity in delayed type hypersensitivity. J Cell Physiol. 1997, 171: 305-317. 10.1002\/(SICI)1097-4652(199706)171:3<305::AID-JCP9>3.0.CO;2-S.","journal-title":"J Cell Physiol"},{"key":"382_CR32","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S0301-472X(98)00082-4","volume":"27","author":"M R\u00f6sel","year":"1999","unstructured":"R\u00f6sel M, Khaldoyanidi S, Zawadzki V, Z\u00f6ller M: Involvement of CD44 variant isoform v10 in progenitor cell adhesion and maturation. Exp Hematol. 1999, 27: 698-711. 10.1016\/S0301-472X(98)00082-4.","journal-title":"Exp Hematol"},{"key":"382_CR33","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3109\/10428190009059265","volume":"38","author":"M Z\u00f6ller","year":"2000","unstructured":"Z\u00f6ller M: CD44v10 in hematopoiesis and stem cell mobilization. Leuk Lymph. 2000, 38: 463-480. 10.3109\/10428190009059265.","journal-title":"Leuk Lymph"},{"key":"382_CR34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/(SICI)1096-9896(199812)186:4<383::AID-PATH202>3.0.CO;2-A","volume":"186","author":"C Beham-Schmid","year":"1998","unstructured":"Beham-Schmid C, Heider KH, Hoefler G, Zatloukal K: Expression of CD44 splice variant v10 in Hodgkin\u2019s disease is associated with aggressive behaviour and high risk of relapse. J Pathol. 1998, 186: 383-389. 10.1002\/(SICI)1096-9896(199812)186:4<383::AID-PATH202>3.0.CO;2-A.","journal-title":"J Pathol"},{"key":"382_CR35","first-page":"2862","volume":"61","author":"K Asosingh","year":"2001","unstructured":"Asosingh K, G\u00fcnthert U, De Raeve H, Van Riet I, Van Camp B, Vanderkerken K: A unique pathway in the homing of murine multiple myeloma cells: CD44v10 mediates binding to bone marrow endothelium. Cancer Res. 2001, 61: 2862-2865.","journal-title":"Cancer Res"},{"key":"382_CR36","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.exphem.2010.10.010","volume":"39","author":"M Schubert","year":"2011","unstructured":"Schubert M, Herbert N, Taubert I, Ran D, Singh R, Eckstein V, Vitacolonna M, Ho AD, Z\u00f6ller M: Differential survival of AML subpopulations in NOD\/SCID mice. Exp Hematol. 2011, 39: 250-263. 10.1016\/j.exphem.2010.10.010.","journal-title":"Exp Hematol"},{"key":"382_CR37","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1038\/leu.2010.214","volume":"24","author":"JP L\u00e9vesque","year":"2010","unstructured":"L\u00e9vesque JP, Helwani FM, Winkler IG: The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia. 2010, 24: 1979-1992. 10.1038\/leu.2010.214.","journal-title":"Leukemia"},{"key":"382_CR38","doi-asserted-by":"publisher","first-page":"4936","DOI":"10.1158\/1078-0432.CCR-10-1499","volume":"17","author":"L Li","year":"2011","unstructured":"Li L, Bhatia R: Stem cell quiescence. Clin Cancer Res. 2011, 17: 4936-4941. 10.1158\/1078-0432.CCR-10-1499.","journal-title":"Clin Cancer Res"},{"key":"382_CR39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.beha.2011.01.005","volume":"24","author":"P Bianco","year":"2011","unstructured":"Bianco P, Sacchetti B, Riminucci M: Osteoprogenitors and the hematopoietic microenvironment. Best Pract Res Clin Haematol. 2011, 24: 37-47. 10.1016\/j.beha.2011.01.005.","journal-title":"Best Pract Res Clin Haematol"},{"key":"382_CR40","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/sj.leu.2404723","volume":"21","author":"T Lwin","year":"2007","unstructured":"Lwin T, Hazlehurst LA, Li Z, Dessureault S, Sotomayor E, Moscinski LC, Dalton WS, Tao J: Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB\/p52) in non-Hodgkin's lymphoma cells. Leukemia. 2007, 21: 1521-1531. 10.1038\/sj.leu.2404723.","journal-title":"Leukemia"},{"key":"382_CR41","first-page":"49","volume":"5","author":"M Das","year":"2010","unstructured":"Das M, Chatterjee S, Basak P, Das P, Pereira JA, Dutta RK, Chaklader M, Chaudhuri S, Law S: The bone marrow stem stromal imbalance\u2013a key feature of disease progression in case of myelodysplastic mouse model. J Stem Cells. 2010, 5: 49-64.","journal-title":"J Stem Cells"},{"key":"382_CR42","first-page":"37","volume":"2012","author":"BA Drew","year":"1825","unstructured":"Drew BA, Burow ME, Beckman BS: MEK5\/ERK5 pathway: the first fifteen years. Biochim Biophys Acta. 1825, 2012: 37-48.","journal-title":"Biochim Biophys Acta"},{"key":"382_CR43","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/jcp.22903","volume":"227","author":"G Verma","year":"2012","unstructured":"Verma G, Datta M: The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death. J Cell Physiol. 2012, 227: 1791-1795. 10.1002\/jcp.22903.","journal-title":"J Cell Physiol"},{"key":"382_CR44","doi-asserted-by":"publisher","first-page":"4736","DOI":"10.4049\/jimmunol.173.7.4736","volume":"173","author":"E Avin","year":"2004","unstructured":"Avin E, Haimovich J, Hollander N: Anti-idiotype x anti-CD44 bispecific antibodies inhibit invasion of lymphoid organs by B cell lymphoma. J Immunol. 2004, 173: 4736-4743.","journal-title":"J Immunol"},{"key":"382_CR45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1136\/mp.52.4.189","volume":"52","author":"S Goodison","year":"1999","unstructured":"Goodison S, Urquidi V, Tarin D: CD44 cell adhesion molecules. Mol Pathol. 1999, 52: 189-196. 10.1136\/mp.52.4.189.","journal-title":"Mol Pathol"},{"key":"382_CR46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/BF03033699","volume":"8","author":"E Akisik","year":"2002","unstructured":"Akisik E, Bavbek S, Dalay N: CD44 variant exons in leukemia and lymphoma. Pathol Oncol Res. 2002, 8: 36-40. 10.1007\/BF03033699.","journal-title":"Pathol Oncol Res"},{"key":"382_CR47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0005-2728(01)00198-0","volume":"1552","author":"GF Weber","year":"2001","unstructured":"Weber GF: The metastasis gene osteopontin: a candidate target for cancer therapy. Biochim Biophys Acta. 2001, 1552: 61-85.","journal-title":"Biochim Biophys Acta"},{"key":"382_CR48","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1182\/blood-2004-11-4422","volume":"106","author":"SK Nilsson","year":"2005","unstructured":"Nilsson SK, Johnston HM, Whitty GA, Williams B, Webb RJ, Denhardt DT, Bertoncello I, Bendall LJ, Simmons PJ, Haylock DN: Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood. 2005, 106: 1232-1239. 10.1182\/blood-2004-11-4422.","journal-title":"Blood"},{"key":"382_CR49","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.4161\/cc.4.10.2056","volume":"4","author":"DN Haylock","year":"2005","unstructured":"Haylock DN, Nilsson SK: Stem cell regulation by the hematopoietic stem cell niche. Cell Cycle. 2005, 4: 1353-1355. 10.4161\/cc.4.10.2056.","journal-title":"Cell Cycle"},{"key":"382_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-8722-6-1","volume":"6","author":"JD Mellor","year":"2013","unstructured":"Mellor JD, Brown MP, Irving HR, Zalcberg JR, Dobrovic A: A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer. J Hematol Oncol. 2013, 6: 1-10.1186\/1756-8722-6-1.","journal-title":"J Hematol Oncol"},{"key":"382_CR51","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1517\/14712598.2012.758705","volume":"13","author":"D Bhutani","year":"2013","unstructured":"Bhutani D, Vaishampayan UN: Monoclonal antibodies in oncology therapeutics: present and future indications. Expert Opin Biol Ther. 2013, 13: 269-282. 10.1517\/14712598.2012.758705.","journal-title":"Expert Opin Biol Ther"},{"key":"382_CR52","doi-asserted-by":"publisher","first-page":"e9093","DOI":"10.1371\/journal.pone.0009093","volume":"5","author":"AP de Barros","year":"2010","unstructured":"de Barros AP, Takiya CM, Garzoni LR, Leal-Ferreira ML, Dutra HS, Chiarini LB, Meirelles MN, Borojevic R, Rossi MI: Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model. PLoS One. 2010, 5: e9093-10.1371\/journal.pone.0009093.","journal-title":"PLoS One"},{"key":"382_CR53","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.1128\/MCB.01348-09","volume":"30","author":"A Sumitomo","year":"2010","unstructured":"Sumitomo A, Ishino R, Urahama N, Inoue K, Yonezawa K, Hasegawa N, Horie O, Matsuoka H, Kondo T, Roeder RG, Ito M: The transcriptional mediator subunit MED1\/TRAP220 in stromal cells is involved in hematopoietic stem\/progenitor cell support through osteopontin expression. Mol Cell Biol. 2010, 30: 4818-4827. 10.1128\/MCB.01348-09.","journal-title":"Mol Cell Biol"},{"key":"382_CR54","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/1042819021000037985","volume":"44","author":"K Hattori","year":"2003","unstructured":"Hattori K, Heissig B, Rafii S: The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. Leuk Lymphoma. 2003, 44: 575-582. 10.1080\/1042819021000037985.","journal-title":"Leuk Lymphoma"},{"key":"382_CR55","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s12015-010-9183-9","volume":"7","author":"A Stanevsky","year":"2011","unstructured":"Stanevsky A, Shimoni A, Yerushalmi R, Nagler A: Cord blood stem cells for hematopoietic transplantation. Stem Cell Rev. 2011, 7: 425-433. 10.1007\/s12015-010-9183-9.","journal-title":"Stem Cell Rev"},{"key":"382_CR56","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.diff.2013.06.004","volume":"86","author":"HJ Lee","year":"2013","unstructured":"Lee HJ, Li N, Evans SM, Diaz MF, Wenzel PL: Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling. Differentiation. 2013, 86: 92-103. 10.1016\/j.diff.2013.06.004.","journal-title":"Differentiation"},{"key":"382_CR57","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/444827a","volume":"444","author":"DA Williams","year":"2006","unstructured":"Williams DA, Cancelas JA: Leukaemia: niche retreats for stem cells. Nature. 2006, 444: 827-828. 10.1038\/444827a.","journal-title":"Nature"},{"key":"382_CR58","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1182\/blood-2003-04-1218","volume":"103","author":"Z Gadhoum","year":"2004","unstructured":"Gadhoum Z, Leibovitch MP, Qi J, Dumenil D, Durand L, Leibovitch S, Smadja-Joffe F: CD44: a new means to inhibit acute myeloid leukemia cell proliferation via p27Kip1. Blood. 2004, 103: 1059-1068.","journal-title":"Blood"},{"key":"382_CR59","doi-asserted-by":"publisher","first-page":"5741","DOI":"10.1038\/sj.onc.1209581","volume":"25","author":"C Artus","year":"2006","unstructured":"Artus C, Maquarre E, Moubarak RS, Delettre C, Jasmin C, Susin SA, Robert-L\u00e9z\u00e9n\u00e8s J: CD44 ligation induces caspase-independent cell death via a novel calpain\/AIF pathway in human erythroleukemia cells. Oncogene. 2006, 25: 5741-5751. 10.1038\/sj.onc.1209581.","journal-title":"Oncogene"},{"key":"382_CR60","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1038\/sj.onc.1206393","volume":"22","author":"AA Zada","year":"2003","unstructured":"Zada AA, Singh SM, Reddy VA, Els\u00e4sser A, Meisel A, Haferlach T, Tenen DG, Hiddemann W, Behre G: Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation. Oncogene. 2003, 22: 2296-2308. 10.1038\/sj.onc.1206393.","journal-title":"Oncogene"},{"key":"382_CR61","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.exphem.2013.09.007","volume":"41","author":"ST Bakker","year":"2013","unstructured":"Bakker ST, Passegu\u00e9 E: Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells. Exp Hematol. 2013, 41: 915-923. 10.1016\/j.exphem.2013.09.007.","journal-title":"Exp Hematol"},{"key":"382_CR62","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni1387","volume":"7","author":"M Scheller","year":"2006","unstructured":"Scheller M, Huelsken J, Rosenbauer F, Taketo MM, Birchmeier W, Tenen DG, Leutz A: Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol. 2006, 7: 1037-1047. 10.1038\/ni1387.","journal-title":"Nat Immunol"},{"key":"382_CR63","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1365-2141.2010.08471.x","volume":"152","author":"EK Siapati","year":"2011","unstructured":"Siapati EK, Papadaki M, Kozaou Z, Rouka E, Michali E, Savvidou I, Gogos D, Kyriakou D, Anagnostopoulos NI, Vassilopoulos G: Proliferation and bone marrow engraftment of AML blasts is dependent on \u03b2-catenin signalling. Br J Haematol. 2011, 152: 164-174. 10.1111\/j.1365-2141.2010.08471.x.","journal-title":"Br J Haematol"},{"key":"382_CR64","volume-title":"Leukemia","author":"LG Schuettpelz","year":"2014","unstructured":"Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC:HYPERLINK \"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24518205\" G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling.Leukemia. 2014, doi:10.1038\/leu.2014.68. [Epub ahead of print],"},{"key":"382_CR65","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1182\/blood-2012-02-412890","volume":"121","author":"B Zhang","year":"2013","unstructured":"Zhang B, Li M, McDonald T, Holyoake TL, Moon RT, Campana D, Shultz L, Bhatia R: Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-\u03b2-catenin signaling. Blood. 2013, 121: 1824-1838. 10.1182\/blood-2012-02-412890.","journal-title":"Blood"},{"key":"382_CR66","doi-asserted-by":"publisher","first-page":"5091","DOI":"10.1073\/pnas.0610819104","volume":"104","author":"L Yang","year":"2007","unstructured":"Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y: Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci U S A. 2007, 104: 5091-5096. 10.1073\/pnas.0610819104.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"382_CR67","doi-asserted-by":"publisher","first-page":"e17498","DOI":"10.1371\/journal.pone.0017498","volume":"6","author":"BR Chitteti","year":"2011","unstructured":"Chitteti BR, Liu Y, Srour EF: Genomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells. PLoS One. 2011, 6: e17498-10.1371\/journal.pone.0017498.","journal-title":"PLoS One"},{"key":"382_CR68","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2174\/157488810793351677","volume":"5","author":"P Basak","year":"2010","unstructured":"Basak P, Chatterjee S, Das M, Das P, Pereira JA, Dutta RK, Chaklader M, Chaudhuri S, Law S: Phenotypic alteration of bone marrow HSC and microenvironmental association in experimentally induced leukemia. Curr Stem Cell Res Ther. 2010, 5: 379-386. 10.2174\/157488810793351677.","journal-title":"Curr Stem Cell Res Ther"},{"key":"382_CR69","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.drup.2009.06.001","volume":"12","author":"M Konopleva","year":"2009","unstructured":"Konopleva M, Tabe Y, Zeng Z, Andreeff M: Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches. Drug Resist Updat. 2009, 12: 103-113. 10.1016\/j.drup.2009.06.001.","journal-title":"Drug Resist Updat"},{"key":"382_CR70","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1517\/14728222.2014.851671","volume":"18","author":"MZ Ratajczak","year":"2014","unstructured":"Ratajczak MZ, Suszynska M, Borkowska S, Ratajczak J, Schneider G:HYPERLINK \"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24188167\" The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells.Expert Opin Ther Targets. 2014, 18: 95-107. 10.1517\/14728222.2014.851671.","journal-title":"Expert Opin Ther Targets"},{"key":"382_CR71","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1038\/leu.2013.193","volume":"27","author":"S Geyh","year":"2013","unstructured":"Geyh S, Oz S, Cadeddu RP, Fr\u00f6bel J, Br\u00fcckner B, K\u00fcndgen A, Fenk R, Bruns I, Zilkens C, Hermsen D, Gattermann N, Kobbe G, Germing U, Lyko F, Haas R, Schroeder T: Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells. Leukemia. 2013, 27: 1841-1851. 10.1038\/leu.2013.193.","journal-title":"Leukemia"},{"key":"382_CR72","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1084\/jem.20041992","volume":"201","author":"S Stier","year":"2005","unstructured":"Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Gr\u00fcnewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, Scadden DT: Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 2005, 201: 1781-1791. 10.1084\/jem.20041992.","journal-title":"J Exp Med"},{"key":"382_CR73","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1179\/102453309X426236","volume":"14","author":"M Onoda","year":"2009","unstructured":"Onoda M, Nakaseko C, Yokota A, Saito Y: Ligation of CD44 with low-molecular-weight hyaluronan and a monoclonal antibody leads to inhibition of drug-induced apoptosis in a human myeloid cell line. Hematology. 2009, 14: 213-219. 10.1179\/102453309X426236.","journal-title":"Hematology"},{"key":"382_CR74","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.ejcb.2006.05.009","volume":"85","author":"R Stern","year":"2006","unstructured":"Stern R, Asari AA, Sugahara KN: Hyaluronan fragments: an information-rich system. Eur J Cell Biol. 2006, 85: 699-715. 10.1016\/j.ejcb.2006.05.009.","journal-title":"Eur J Cell Biol"},{"key":"382_CR75","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.drup.2008.04.002","volume":"11","author":"BP Toole","year":"2008","unstructured":"Toole BP, Slomiany MG: Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist Updat. 2008, 11: 110-121. 10.1016\/j.drup.2008.04.002.","journal-title":"Drug Resist Updat"},{"key":"382_CR76","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1182\/blood-2003-07-2340","volume":"103","author":"Y Nefedova","year":"2004","unstructured":"Nefedova Y, Cheng P, Alsina M, Dalton WS, Gabrilovich DI: Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood. 2004, 103: 3503-3510. 10.1182\/blood-2003-07-2340.","journal-title":"Blood"},{"key":"382_CR77","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/leu.2008.266","volume":"23","author":"T Lwin","year":"2009","unstructured":"Lwin T, Crespo LA, Wu A, Dessureault S, Shu HB, Moscinski LC, Sotomayor E, Dalton WS, Tao J: Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis. Leukemia. 2009, 23: 170-177. 10.1038\/leu.2008.266.","journal-title":"Leukemia"},{"key":"382_CR78","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0014-5793(02)03262-3","volume":"528","author":"Y Fujita","year":"2002","unstructured":"Fujita Y, Kitagawa M, Nakamura S, Azuma K, Ishii G, Higashi M, Kishi H, Hiwasa T, Koda K, Nakajima N, Harigaya K: CD44 signaling through focal adhesion kinase and its anti-apoptotic effect. FEBS Lett. 2002, 528: 101-108. 10.1016\/S0014-5793(02)03262-3.","journal-title":"FEBS Lett"},{"key":"382_CR79","doi-asserted-by":"publisher","first-page":"15862","DOI":"10.1074\/jbc.M110.208421","volume":"286","author":"T Jung","year":"2011","unstructured":"Jung T, Gross W, Z\u00f6ller M: CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance. J Biol Chem. 2011, 286: 15862-15874. 10.1074\/jbc.M110.208421.","journal-title":"J Biol Chem"},{"key":"382_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0609.2009.01348.x","volume":"84","author":"D Vasilatou","year":"2010","unstructured":"Vasilatou D, Papageorgiou S, Pappa V, Papageorgiou E, Dervenoulas J: The role of microRNAs in normal and malignant hematopoiesis. Eur J Haematol. 2010, 84: 1-16. 10.1111\/j.1600-0609.2009.01348.x.","journal-title":"Eur J Haematol"},{"key":"382_CR81","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/bjh.12276","volume":"161","author":"H Zhan","year":"2013","unstructured":"Zhan H, Cardozo C, Raza A: MicroRNAs in myeloproliferative neoplasms. Br J Haematol. 2013, 161: 471-483. 10.1111\/bjh.12276.","journal-title":"Br J Haematol"},{"key":"382_CR82","volume-title":"Calcif Tissue Int","author":"LM Calvi","year":"2013","unstructured":"Calvi LM, Link DC: Cellular Complexity of the Bone Marrow Hematopoietic Stem Cell Niche. Calcif Tissue Int. 2013, [Epub ahead of print]"},{"key":"382_CR83","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.2174\/138161212799859657","volume":"18","author":"S Fulle","year":"2012","unstructured":"Fulle S, Centurione L, Mancinelli R, Sancilio S, Manzoli FA, Di Pietro R: Stem cell ageing and apoptosis. Curr Pharm Des. 2012, 18: 1694-1717. 10.2174\/138161212799859657.","journal-title":"Curr Pharm Des"},{"key":"382_CR84","first-page":"4856","volume":"39","author":"H Reiter","year":"1979","unstructured":"Reiter H: Effect of thymidine on the survival of mice with EL4 tumors. Cancer Res. 1979, 39: 4856-4860.","journal-title":"Cancer Res"},{"key":"382_CR85","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/(SICI)1097-0215(19980316)75:6<919::AID-IJC15>3.0.CO;2-Y","volume":"75","author":"V Zawadzki","year":"1998","unstructured":"Zawadzki V, Perschl A, R\u00f6sel M, Hekele A, Z\u00f6ller M: Blockade of metastasis formation by CD44-receptor globulin. Int J Cancer. 1998, 75: 919-924. 10.1002\/(SICI)1097-0215(19980316)75:6<919::AID-IJC15>3.0.CO;2-Y.","journal-title":"Int J Cancer"},{"key":"382_CR86","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/eji.1830121103","volume":"12","author":"N Koch","year":"1982","unstructured":"Koch N, H\u00e4mmerling GJ, Tada N, Kimura S, H\u00e4mmerling U: Cross-blocking studies with monoclonal antibodies against I-A molecules of haplotypes b, d and k. Eur J Immunol. 1982, 12: 909-914. 10.1002\/eji.1830121103.","journal-title":"Eur J Immunol"},{"key":"382_CR87","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.biocel.2012.06.018","volume":"44","author":"S Rana","year":"2012","unstructured":"Rana S, Yue S, Stadel D, Z\u00f6ller M: Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection. Int J Biochem Cell Biol. 2012, 44: 1574-1584. 10.1016\/j.biocel.2012.06.018.","journal-title":"Int J Biochem Cell Biol"}],"updated-by":[{"DOI":"10.1186\/s13045-024-01652-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000}}],"container-title":["Journal of Hematology &amp; Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-8722-7-29.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T16:02:42Z","timestamp":1734364962000},"score":1,"resource":{"primary":{"URL":"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/1756-8722-7-29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,31]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["382"],"URL":"https:\/\/doi.org\/10.1186\/1756-8722-7-29","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s13045-024-01652-4","asserted-by":"object"}]},"ISSN":["1756-8722"],"issn-type":[{"value":"1756-8722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,31]]},"assertion":[{"value":"14 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s13045-024-01652-4","URL":"https:\/\/doi.org\/10.1186\/s13045-024-01652-4","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"29"}}