{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:55:49Z","timestamp":1787198149789,"version":"build-2736575974"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T00:00:00Z","timestamp":1294272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1756-9966-30-3","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T06:16:44Z","timestamp":1295417804000},"source":"Crossref","is-referenced-by-count":70,"title":["Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism"],"prefix":"10.1186","volume":"30","author":[{"given":"Dirk W","family":"Lachenmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia B","family":"Monakhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,6]]},"reference":[{"key":"423_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0165-1218(91)90128-9","volume":"259","author":"VJ Feron","year":"1991","unstructured":"Feron VJ, Til HP, de Vrijer F, Woutersen RA, Cassee FR, van Bladeren PJ: Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutat Res. 1991, 259: 363-385. 10.1016\/0165-1218(91)90128-9.","journal-title":"Mutat Res"},{"key":"423_CR2","first-page":"30","volume":"106","author":"DW Lachenmeier","year":"2010","unstructured":"Lachenmeier DW, Uebelacker M, Hensel K, Rehm J: Acetaldehyde in the human diet: An underestimated risk factor for cancer. Deut Lebensm Rundsch. 2010, 106: 30-35.","journal-title":"Deut Lebensm Rundsch"},{"key":"423_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1365-2621.2000.00341.x","volume":"35","author":"SQ Liu","year":"2000","unstructured":"Liu SQ, Pilone GJ: An overview of formation and roles of acetaldehyde in winemaking with emphasis on microbiological implications. Int J Food Sci Technol. 2000, 35: 49-61. 10.1046\/j.1365-2621.2000.00341.x.","journal-title":"Int J Food Sci Technol"},{"key":"423_CR4","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1016\/j.fct.2008.05.034","volume":"46","author":"DW Lachenmeier","year":"2008","unstructured":"Lachenmeier DW, Sohnius EM: The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: evidence from a large chemical survey. Food Chem Toxicol. 2008, 46: 2903-2911. 10.1016\/j.fct.2008.05.034.","journal-title":"Food Chem Toxicol"},{"key":"423_CR5","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S1470-2045(09)70326-2","volume":"10","author":"B Secretan","year":"2009","unstructured":"Secretan B, Straif K, Baan R, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V: A review of human carcinogens - Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol. 2009, 10: 1033-1034. 10.1016\/S1470-2045(09)70326-2.","journal-title":"Lancet Oncol"},{"key":"423_CR6","first-page":"1","volume":"96","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2010","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: Alcohol consumption and ethyl carbamate. IARC Monogr Eval Carcinog Risks Hum. 2010, 96: 1-1428.","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"423_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S1470-2045(07)70099-2","volume":"8","author":"R Baan","year":"2007","unstructured":"Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Altieri A, Cogliano V, WHO International Agency for Research on Cancer Monograph Working Group: Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007, 8: 292-293. 10.1016\/S1470-2045(07)70099-2.","journal-title":"Lancet Oncol"},{"key":"423_CR8","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1093\/nar\/gki661","volume":"33","author":"JA Theruvathu","year":"2005","unstructured":"Theruvathu JA, Jaruga P, Nath RG, Dizdaroglu M, Brooks PJ: Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde. Nucleic Acids Res. 2005, 33: 3513-3520. 10.1093\/nar\/gki661.","journal-title":"Nucleic Acids Res"},{"key":"423_CR9","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/em.20117","volume":"45","author":"PH Fernandes","year":"2005","unstructured":"Fernandes PH, Kanuri M, Nechev LV, Harris TM, Lloyd RS: Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde. Environ Mol Mutagen. 2005, 45: 455-459. 10.1002\/em.20117.","journal-title":"Environ Mol Mutagen"},{"key":"423_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mrgentox.2006.01.009","volume":"608","author":"S Stein","year":"2006","unstructured":"Stein S, Lao Y, Yang IY, Hecht SS, Moriya M: Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells. Mutat Res. 2006, 608: 1-7.","journal-title":"Mutat Res"},{"key":"423_CR11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/carcin\/9.5.761","volume":"9","author":"N Espina","year":"1988","unstructured":"Espina N, Lima V, Lieber CS, Garro AJ: In vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O6-methylguanine transferase. Carcinogenesis. 1988, 9: 761-766. 10.1093\/carcin\/9.5.761.","journal-title":"Carcinogenesis"},{"key":"423_CR12","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1158\/1055-9965.EPI-05-0196","volume":"14","author":"SJ Lewis","year":"2005","unstructured":"Lewis SJ, Smith GD: Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev. 2005, 14: 1967-1971. 10.1158\/1055-9965.EPI-05-0196.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"423_CR13","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/carcin\/19.8.1383","volume":"19","author":"A Yokoyama","year":"1998","unstructured":"Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H: Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis. 1998, 19: 1383-1387. 10.1093\/carcin\/19.8.1383.","journal-title":"Carcinogenesis"},{"key":"423_CR14","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/j.1530-0277.2000.tb02068.x","volume":"24","author":"S V\u00e4kev\u00e4inen","year":"2000","unstructured":"V\u00e4kev\u00e4inen S, Tillonen J, Agarwal DP, Srivastava N, Salaspuro M: High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: strong evidence for the local carcinogenic action of acetaldehyde. Alcohol Clin Exp Res. 2000, 24: 873-877.","journal-title":"Alcohol Clin Exp Res"},{"key":"423_CR15","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1111\/j.1530-0277.2001.tb02286.x","volume":"25","author":"S V\u00e4kev\u00e4inen","year":"2001","unstructured":"V\u00e4kev\u00e4inen S, Tillonen J, Salaspuro M: 4-Methylpyrazole decreases salivary acetaldehyde levels in ALDH2-deficient subjects but not in subjects with normal ALDH2. Alcohol Clin Exp Res. 2001, 25: 829-834.","journal-title":"Alcohol Clin Exp Res"},{"key":"423_CR16","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1111\/j.1530-0277.2008.00739.x","volume":"32","author":"A Yokoyama","year":"2008","unstructured":"Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Mizukami T, Yokoyama T: Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. Alcohol Clin Exp Res. 2008, 32: 1607-1614. 10.1111\/j.1530-0277.2008.00739.x.","journal-title":"Alcohol Clin Exp Res"},{"key":"423_CR17","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1021\/tx060113h","volume":"19","author":"T Matsuda","year":"2006","unstructured":"Matsuda T, Yabushita H, Kanaly RA, Shibutani S, Yokoyama A: Increased DNA damage in ALDH2-deficient alcoholics. Chem Res Toxicol. 2006, 19: 1374-1378. 10.1021\/tx060113h.","journal-title":"Chem Res Toxicol"},{"key":"423_CR18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0016-5085(90)90832-L","volume":"98","author":"HK Seitz","year":"1990","unstructured":"Seitz HK, Simanowski UA, Garzon FT, Rideout JM, Peters TJ, Koch A, Berger MR, Einecke H, Maiwald M: Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology. 1990, 98: 406-413.","journal-title":"Gastroenterology"},{"key":"423_CR19","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/carcin\/18.9.1739","volume":"18","author":"N Homann","year":"1997","unstructured":"Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M: High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis. 1997, 18: 1739-1743. 10.1093\/carcin\/18.9.1739.","journal-title":"Carcinogenesis"},{"key":"423_CR20","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1093\/jnci\/89.22.1692","volume":"89","author":"N Homann","year":"1997","unstructured":"Homann N, K\u00e4rkk\u00e4inen P, Koivisto T, Nosova T, Jokelainen K, Salaspuro M: Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst. 1997, 89: 1692-1697. 10.1093\/jnci\/89.22.1692.","journal-title":"J Natl Cancer Inst"},{"key":"423_CR21","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.oraloncology.2006.02.005","volume":"43","author":"J Kurkivuori","year":"2007","unstructured":"Kurkivuori J, Salaspuro V, Kaihovaara P, Kari K, Rautemaa R, Gr\u00f6nroos L, Meurman JH, Salaspuro M: Acetaldehyde production from ethanol by oral streptococci. Oral Oncol. 2007, 43: 181-186. 10.1016\/j.oraloncology.2006.02.005.","journal-title":"Oral Oncol"},{"key":"423_CR22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1136\/gut.39.1.100","volume":"39","author":"K Jokelainen","year":"1996","unstructured":"Jokelainen K, Matysiak-Budnik T, M\u00e4kisalo H, H\u00f6ckerstedt K, Salaspuro M: High intracolonic acetaldehyde values produced by a bacteriocolonic pathway for ethanol oxidation in piglets. Gut. 1996, 39: 100-104. 10.1136\/gut.39.1.100.","journal-title":"Gut"},{"key":"423_CR23","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/j.1530-0277.1996.tb01932.x","volume":"20","author":"K Jokelainen","year":"1996","unstructured":"Jokelainen K, Siitonen A, Jousimies-Somer H, Nosova T, Heine R, Salaspuro M: In vitro alcohol dehydrogenase-mediated acetaldehyde production by aerobic bacteria representing the normal colonic flora in man. Alcohol Clin Exp Res. 1996, 20: 967-972. 10.1111\/j.1530-0277.1996.tb01932.x.","journal-title":"Alcohol Clin Exp Res"},{"key":"423_CR24","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/713609333","volume":"40","author":"MP Salaspuro","year":"2003","unstructured":"Salaspuro MP: Acetaldehyde, microbes, and cancer of the digestive tract. Crit Rev Clin Lab Sci. 2003, 40: 183-208. 10.1080\/713609333.","journal-title":"Crit Rev Clin Lab Sci"},{"key":"423_CR25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1080\/13556210020077028","volume":"6","author":"N Homann","year":"2001","unstructured":"Homann N: Alcohol and upper gastrointestinal tract cancer: the role of local acetaldehyde production. Addict Biol. 2001, 6: 309-323. 10.1080\/13556210020077028.","journal-title":"Addict Biol"},{"key":"423_CR26","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S1368-8375(00)00076-2","volume":"37","author":"N Homann","year":"2001","unstructured":"Homann N, Tillonen J, Rintam\u00e4ki H, Salaspuro M, Lindqvist C, Meurman JH: Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral Oncol. 2001, 37: 153-158. 10.1016\/S1368-8375(00)00076-2.","journal-title":"Oral Oncol"},{"key":"423_CR27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<169::AID-IJC4>3.0.CO;2-3","volume":"86","author":"N Homann","year":"2000","unstructured":"Homann N, Tillonen J, Salaspuro M: Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency. Int J Cancer. 2000, 86: 169-173. 10.1002\/(SICI)1097-0215(20000415)86:2<169::AID-IJC4>3.0.CO;2-3.","journal-title":"Int J Cancer"},{"key":"423_CR28","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1093\/carcin\/21.4.663","volume":"21","author":"N Homann","year":"2000","unstructured":"Homann N, Tillonen J, Meurman JH, Rintam\u00e4ki H, Lindqvist C, Rautio M, Jousimies-Somer H, Salaspuro M: Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. Carcinogenesis. 2000, 21: 663-668. 10.1093\/carcin\/21.4.663.","journal-title":"Carcinogenesis"},{"key":"423_CR29","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S1521-6918(03)00035-0","volume":"17","author":"MP Salaspuro","year":"2003","unstructured":"Salaspuro MP: Alcohol consumption and cancer of the gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2003, 17: 679-694. 10.1016\/S1521-6918(03)00035-0.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"423_CR30","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1360-0443.2009.02516.x","volume":"104","author":"DW Lachenmeier","year":"2009","unstructured":"Lachenmeier DW, Kanteres F, Rehm J: Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. Addiction. 2009, 104: 533-550. 10.1111\/j.1360-0443.2009.02516.x.","journal-title":"Addiction"},{"key":"423_CR31","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.fct.2007.08.019","volume":"46","author":"K Linderborg","year":"2008","unstructured":"Linderborg K, Joly JP, Visap\u00e4\u00e4 JP, Salaspuro M: Potential mechanism for Calvados-related oesophageal cancer. Food Chem Toxicol. 2008, 46: 476-479. 10.1016\/j.fct.2007.08.019.","journal-title":"Food Chem Toxicol"},{"key":"423_CR32","first-page":"16","volume":"L39","author":"European Parliament and Council","year":"2008","unstructured":"European Parliament and Council: Regulation (EC) No 110\/2008 of the European Parliament and of the Council of 15 January 2008 on the definition, description, presentation, labelling and the protection of geographical indications of spirit drinks and repealing Council Regulation (EEC) No 1576\/89. Off J Europ Union. 2008, L39: 16-54.","journal-title":"Off J Europ Union"},{"key":"423_CR33","first-page":"358","volume":"2000","author":"Ministerium L\u00e4ndlicher Raum","year":"2000","unstructured":"Ministerium L\u00e4ndlicher Raum: Verwaltungsvorschrift des Ministeriums L\u00e4ndlicher Raum \u00fcber die Dienstaufgaben und Zust\u00e4ndigkeitsbereiche der Chemischen und Veterin\u00e4runtersuchungs\u00e4mter und des Staatlichen Tier\u00e4rztlichen Untersuchungsamtes Aulendorf - Diagnostikzentrum [Administrative regulation of the Ministry of Rural Affairs regarding the official duties and jurisdiction of the Chemical and Veterinary Investigation Laboratories and the State Veterinary Laboratory Aulendorf - center of diagnostic investigations]. GABl. 2000, 2000: 358-359.","journal-title":"GABl"},{"key":"423_CR34","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.foodchem.2005.12.032","volume":"101","author":"DW Lachenmeier","year":"2007","unstructured":"Lachenmeier DW: Rapid quality control of spirit drinks and beer using multivariate data analysis of Fourier transform infrared spectra. Food Chem. 2007, 101: 825-832. 10.1016\/j.foodchem.2005.12.032.","journal-title":"Food Chem"},{"key":"423_CR35","first-page":"20","volume":"L333","author":"European Commission","year":"2000","unstructured":"European Commission: Commission Regulation (EC) No 2870\/2000 laying down Community reference methods for the analysis of spirits drinks. Off J Europ Comm. 2000, L333: 20-46.","journal-title":"Off J Europ Comm"},{"key":"423_CR36","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1021\/jf060094h","volume":"54","author":"DW Lachenmeier","year":"2006","unstructured":"Lachenmeier DW, Sohnius E-M, Attig R, L\u00f3pez MG: Quantification of selected volatile constituents and anions in mexican Agave spirits (Tequila, Mezcal, Sotol. Bacanora). J Agric Food Chem. 2006, 54: 3911-3915. 10.1021\/jf060094h.","journal-title":"J Agric Food Chem"},{"key":"423_CR37","first-page":"1509","volume-title":"Methods of enzymatic analysis","author":"F Lundquist","year":"1974","unstructured":"Lundquist F: Determination with aldehyde dehydrogenase. Methods of enzymatic analysis. Edited by: Bergmeier HU. 1974, Weinheim\/New York and London: Verlag Chemie\/Academic Press, 3: 1509-1513. 2","edition":"2"},{"key":"423_CR38","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1042\/bj0680172","volume":"68","author":"F Lundquist","year":"1958","unstructured":"Lundquist F: Enzymic determination of acetaldehyde in blood. Biochem J. 1958, 68: 172-177.","journal-title":"Biochem J"},{"key":"423_CR39","first-page":"606","volume-title":"Methods of enzymatic analysis","author":"HO Beutler","year":"1984","unstructured":"Beutler HO: Acetaldehyde (Ethanal). Methods of enzymatic analysis. Edited by: Bergmeier HU. 1984, Weinheim, Deerfield Beach\/Florida, Basel: Verlag Chemie, VI: 606-613. 3","edition":"3"},{"key":"423_CR40","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/ijc.24381","volume":"125","author":"DW Lachenmeier","year":"2009","unstructured":"Lachenmeier DW, Gumbel-Mako S, Sohnius EM, Keck-Wilhelm A, Kratz E, Mildau G: Salivary acetaldehyde increase due to alcohol-containing mouthwash use: a risk factor for oral cancer. Int J Cancer. 2009, 125: 730-735. 10.1002\/ijc.24381.","journal-title":"Int J Cancer"},{"key":"423_CR41","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.archoralbio.2009.04.011","volume":"54","author":"L Ernstg\u00e5rd","year":"2009","unstructured":"Ernstg\u00e5rd L: Influence of gender on the metabolism of alcohols in human saliva in vitro. Arch Oral Biol. 2009, 54: 737-742.","journal-title":"Arch Oral Biol"},{"key":"423_CR42","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/gut.2003.018994","volume":"53","author":"JP Visap\u00e4\u00e4","year":"2004","unstructured":"Visap\u00e4\u00e4 JP, G\u00f6tte K, Benesova M, Li J, Homann N, Conradt C, Inoue H, Tisch M, H\u00f6rrmann K, V\u00e4kev\u00e4inen S, Salaspuro M, Seitz HK: Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. Gut. 2004, 53: 871-876.","journal-title":"Gut"},{"key":"423_CR43","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1111\/j.1530-0277.2009.01080.x","volume":"34","author":"A Yokoyama","year":"2010","unstructured":"Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T: Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. Alcohol Clin Exp Res. 2010, 34: 1246-1256. 10.1111\/j.1530-0277.2009.01080.x.","journal-title":"Alcohol Clin Exp Res"},{"key":"423_CR44","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/9780470511848.ch18","volume":"285","author":"CJ Eriksson","year":"2007","unstructured":"Eriksson CJ: Measurement of acetaldehyde: what levels occur naturally and in response to alcohol?. Novartis Found Symp. 2007, 285: 247-255. full_text.","journal-title":"Novartis Found Symp"},{"key":"423_CR45","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0027-5107(77)90213-5","volume":"56","author":"G Obe","year":"1977","unstructured":"Obe G, Ristow H: Acetaldehyde, but not ethanol, induces sister chromatid exchanges in Chinese hamster cells in vitro. Mutat Res. 1977, 56: 211-213.","journal-title":"Mutat Res"},{"key":"423_CR46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/9780470511848.ch6","volume":"285","author":"M Salaspuro","year":"2007","unstructured":"Salaspuro M: Interrelationship between alcohol, smoking, acetaldehyde and cancer. Novartis Found Symp. 2007, 285: 80-89. full_text.","journal-title":"Novartis Found Symp"},{"key":"423_CR47","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/BF00051654","volume":"3","author":"I Kato","year":"1992","unstructured":"Kato I, Nomura AM, Stemmermann GN, Chyou PH: Prospective study of the association of alcohol with cancer of the upper aerodigestive tract and other sites. Cancer Causes Control. 1992, 3: 145-151. 10.1007\/BF00051654.","journal-title":"Cancer Causes Control"},{"key":"423_CR48","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/BF01804984","volume":"5","author":"LM Brown","year":"1994","unstructured":"Brown LM, Silverman DT, Pottern LM, Schoenberg JB, Greenberg RS, Swanson GM, Liff JM, Schwartz AG, Hayes RB, Blot WJ: Adenocarcinoma of the esophagus and esophagogastric junction in white men in the United States: alcohol, tobacco, and socioeconomic factors. Cancer Causes Control. 1994, 5: 333-340. 10.1007\/BF01804984.","journal-title":"Cancer Causes Control"},{"key":"423_CR49","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1093\/jnci\/89.17.1277","volume":"89","author":"MD Gammon","year":"1997","unstructured":"Gammon MD, Schoenberg JB, Ahsan H, Risch HA, Vaughan TL, Chow WH, Rotterdam H, West AB, Dubrow R, Stanford JL, Mayne ST, Farrow DC, Niwa S, Blot WJ, Fraumeni JF: Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst. 1997, 89: 1277-1284. 10.1093\/jnci\/89.17.1277.","journal-title":"J Natl Cancer Inst"},{"key":"423_CR50","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1136\/bmj.317.7162.844","volume":"317","author":"M Gr\u00f8nbaek","year":"1998","unstructured":"Gr\u00f8nbaek M, Becker U, Johansen D, Tonnesen H, Jensen G, Sorensen TI: Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract. BMJ. 1998, 317: 844-847.","journal-title":"BMJ"},{"key":"423_CR51","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1023\/A:1008809706062","volume":"9","author":"K Kjaerheim","year":"1998","unstructured":"Kjaerheim K, Gaard M, Andersen A: The role of alcohol, tobacco, and dietary factors in upper aerogastric tract cancers: a prospective study of 10,900 Norwegian men. Cancer Causes Control. 1998, 9: 99-108. 10.1023\/A:1008809706062.","journal-title":"Cancer Causes Control"},{"key":"423_CR52","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<340::AID-IJC8>3.0.CO;2-N","volume":"85","author":"J Lagergren","year":"2000","unstructured":"Lagergren J, Bergstr\u00f6m R, Lindgren A, Nyr\u00e9n O: The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia. Int J Cancer. 2000, 85: 340-346. 10.1002\/(SICI)1097-0215(20000201)85:3<340::AID-IJC8>3.0.CO;2-N.","journal-title":"Int J Cancer"},{"key":"423_CR53","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/ijc.2910460612","volume":"46","author":"S Barra","year":"1990","unstructured":"Barra S, Franceschi S, Negri E, Talamini R, La Vecchia C: Type of alcoholic beverage and cancer of the oral cavity, pharynx and oesophagus in an Italian area with high wine consumption. Int J Cancer. 1990, 46: 1017-1020. 10.1002\/ijc.2910460612.","journal-title":"Int J Cancer"},{"issue":"Suppl 2","key":"423_CR54","doi-asserted-by":"publisher","first-page":"S212","DOI":"10.2188\/jea.15.S212","volume":"15","author":"K Sakata","year":"2005","unstructured":"Sakata K, Hoshiyama Y, Morioka S, Hashimoto T, Takeshita T, Tamakoshi A: Smoking, alcohol drinking and esophageal cancer: findings from the JACC Study. J Epidemiol. 2005, 15 (Suppl 2): S212-S219. 10.2188\/jea.15.S212.","journal-title":"J Epidemiol"},{"key":"423_CR55","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/009145090403100304","volume":"31","author":"G Gmel","year":"2004","unstructured":"Gmel G, Rehm J: Measuring alcohol consumption. Contemp Drug Probl. 2004, 31: 467-540.","journal-title":"Contemp Drug Probl"},{"key":"423_CR56","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2174\/1874340400903010030","volume":"3","author":"DW Lachenmeier","year":"2009","unstructured":"Lachenmeier DW: Carcinogens in food: opportunities and challenges for regulatory toxicology. Open Toxicol J. 2009, 3: 30-34. 10.2174\/1874340400903010030.","journal-title":"Open Toxicol J"}],"container-title":["Journal of Experimental &amp; Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-9966-30-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-9966-30-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-9966-30-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T03:22:01Z","timestamp":1548213721000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/1756-9966-30-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,6]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["423"],"URL":"https:\/\/doi.org\/10.1186\/1756-9966-30-3","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,6]]},"article-number":"3"}}